Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-naïve celiac disease

Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-naïve celiac disease

Objectives: We hypothesized that crypt failure in the small bowel results in villous flattening in patients with celiac disease (CeD). We investigated whether alterations in the stem cell niche (ISC) are responsible for this phenomenon. Materials and Methods: We included 92 duodenal (D2/3) biopsies...

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Main Authors: Prasenjit Das, Sudha Battu, Lalita Mehra, Alka Singh, Muzaffar Ahmad, Ashish Agarwal, Ashish Chauhan, Anam Ahmad, Sreenivas Vishnubhatla, Siddhartha Datta Gupta, Vineet Ahuja, Govind Makharia
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-04-01
Series:Indian Journal of Pathology and Microbiology
Subjects:
celiac disease
crypts
fibronectin
immunofluorescence
immunohistochemistry
intestinal stem cell
niche
stroma
Online Access:https://journals.lww.com/10.4103/ijpm.ijpm_760_23
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