Corneal Endothelial Cell Loss in Glaucoma and Glaucoma Surgery and the Utility of Management with Descemet Membrane Endothelial Keratoplasty (DMEK)
The corneal endothelium has a crucial role in maintaining a clear and healthy cornea. Corneal endothelial cell loss occurs naturally with age; however, a diagnosis of glaucoma and surgical intervention for glaucoma can exacerbate a decline in cell number and impairment in morphology. In glaucoma, th...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2022/1315299 |
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| author | Neeru A Vallabh Stephnie Kennedy Riccardo Vinciguerra Keri McLean Hannah Levis Davide Borroni Vito Romano Colin E Willoughby |
| author_facet | Neeru A Vallabh Stephnie Kennedy Riccardo Vinciguerra Keri McLean Hannah Levis Davide Borroni Vito Romano Colin E Willoughby |
| author_sort | Neeru A Vallabh |
| collection | DOAJ |
| description | The corneal endothelium has a crucial role in maintaining a clear and healthy cornea. Corneal endothelial cell loss occurs naturally with age; however, a diagnosis of glaucoma and surgical intervention for glaucoma can exacerbate a decline in cell number and impairment in morphology. In glaucoma, the mechanisms for this are not well understood and this accelerated cell loss can result in corneal decompensation. Given the high prevalence of glaucoma worldwide, this review aims to explore the abnormalities observed in the corneal endothelium in differing glaucoma phenotypes and glaucoma therapies (medical or surgical including with new generation microinvasive glaucoma surgeries). Descemet membrane endothelial keratoplasty (DMEK) is increasingly being used to manage corneal endothelial failure for glaucoma patients and we aim to review the recent literature evaluating the use of this technique in this clinical scenario. |
| format | Article |
| id | doaj-art-b1fbd63474a444a38d9d835729a9c131 |
| institution | Kabale University |
| issn | 2090-0058 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-b1fbd63474a444a38d9d835729a9c1312025-02-03T06:07:33ZengWileyJournal of Ophthalmology2090-00582022-01-01202210.1155/2022/1315299Corneal Endothelial Cell Loss in Glaucoma and Glaucoma Surgery and the Utility of Management with Descemet Membrane Endothelial Keratoplasty (DMEK)Neeru A Vallabh0Stephnie Kennedy1Riccardo Vinciguerra2Keri McLean3Hannah Levis4Davide Borroni5Vito Romano6Colin E Willoughby7Department of Corneal and External Eye DiseasesDepartment of Eye and Vision ScienceDepartment of Corneal and External Eye DiseasesDepartment of Corneal and External Eye DiseasesDepartment of Eye and Vision ScienceDepartment of Corneal and External Eye DiseasesDepartment of Corneal and External Eye DiseasesGenomic MedicineThe corneal endothelium has a crucial role in maintaining a clear and healthy cornea. Corneal endothelial cell loss occurs naturally with age; however, a diagnosis of glaucoma and surgical intervention for glaucoma can exacerbate a decline in cell number and impairment in morphology. In glaucoma, the mechanisms for this are not well understood and this accelerated cell loss can result in corneal decompensation. Given the high prevalence of glaucoma worldwide, this review aims to explore the abnormalities observed in the corneal endothelium in differing glaucoma phenotypes and glaucoma therapies (medical or surgical including with new generation microinvasive glaucoma surgeries). Descemet membrane endothelial keratoplasty (DMEK) is increasingly being used to manage corneal endothelial failure for glaucoma patients and we aim to review the recent literature evaluating the use of this technique in this clinical scenario.http://dx.doi.org/10.1155/2022/1315299 |
| spellingShingle | Neeru A Vallabh Stephnie Kennedy Riccardo Vinciguerra Keri McLean Hannah Levis Davide Borroni Vito Romano Colin E Willoughby Corneal Endothelial Cell Loss in Glaucoma and Glaucoma Surgery and the Utility of Management with Descemet Membrane Endothelial Keratoplasty (DMEK) Journal of Ophthalmology |
| title | Corneal Endothelial Cell Loss in Glaucoma and Glaucoma Surgery and the Utility of Management with Descemet Membrane Endothelial Keratoplasty (DMEK) |
| title_full | Corneal Endothelial Cell Loss in Glaucoma and Glaucoma Surgery and the Utility of Management with Descemet Membrane Endothelial Keratoplasty (DMEK) |
| title_fullStr | Corneal Endothelial Cell Loss in Glaucoma and Glaucoma Surgery and the Utility of Management with Descemet Membrane Endothelial Keratoplasty (DMEK) |
| title_full_unstemmed | Corneal Endothelial Cell Loss in Glaucoma and Glaucoma Surgery and the Utility of Management with Descemet Membrane Endothelial Keratoplasty (DMEK) |
| title_short | Corneal Endothelial Cell Loss in Glaucoma and Glaucoma Surgery and the Utility of Management with Descemet Membrane Endothelial Keratoplasty (DMEK) |
| title_sort | corneal endothelial cell loss in glaucoma and glaucoma surgery and the utility of management with descemet membrane endothelial keratoplasty dmek |
| url | http://dx.doi.org/10.1155/2022/1315299 |
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