Baicalin: a potential therapeutic agent for acute kidney injury and renal fibrosis
Acute kidney injury (AKI) is a common critical clinical disease that is linked to significant morbidity, recurrence, and mortality. It is characterized by a fast and prolonged loss in renal function arising from numerous etiologies and pathogenic pathways. Renal fibrosis, defined as the excessive ac...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1511083/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591598129512448 |
|---|---|
| author | Xiaoming Li Xiaoming Li Rui Xu Rui Xu Dan Zhang Ji Cai Ji Cai He Zhou He Zhou Tao Song Tao Song Xianyao Wang Xianyao Wang Qinghong Kong Liujin Li Zhaohui Liu Zhixu He Zhengzhen Tang Jun Tan Jidong Zhang Jidong Zhang Jidong Zhang |
| author_facet | Xiaoming Li Xiaoming Li Rui Xu Rui Xu Dan Zhang Ji Cai Ji Cai He Zhou He Zhou Tao Song Tao Song Xianyao Wang Xianyao Wang Qinghong Kong Liujin Li Zhaohui Liu Zhixu He Zhengzhen Tang Jun Tan Jidong Zhang Jidong Zhang Jidong Zhang |
| author_sort | Xiaoming Li |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is a common critical clinical disease that is linked to significant morbidity, recurrence, and mortality. It is characterized by a fast and prolonged loss in renal function arising from numerous etiologies and pathogenic pathways. Renal fibrosis, defined as the excessive accumulation of collagen and proliferation of fibroblasts within renal tissues, contributes to the structural damage and functional decline of the kidneys, playing a pivotal role in the advancement of Chronic Kidney Disease (CKD). Until now, while continuous renal replacement therapy (CRRT) has been utilized in the management of severe AKI, there remains a dearth of effective targeted therapies for AKI stemming from diverse etiologies. Similarly, the identification of specific biomarkers and pharmacological targets for the treatment of renal fibrosis remains a challenge. Baicalin, a naturally occurring compound classified within the flavonoid group and commonly found in the Chinese herb Scutellaria baicalensis, has shown a range of pharmacological characteristics, such as antioxidant, anti-inflammatory, antifibrotic, antitumor and antiviral effects, as evidenced by research studies. Research shows that Baicalin has potential in treating kidney diseases like AKI and renal fibrosis. This review aims to summarize Baicalin’s progress in these areas, including its molecular mechanism, application in treatment, and absorption, distribution, metabolism, and excretion. Baicalin’s therapeutic effects are achieved through various pathways, including antioxidant, anti-inflammatory, antifibrosis, and regulation of apoptosis and cell proliferation. Besides, we also hope this review may give some enlightenment for treating AKI and renal fibrosis in clinical practice. |
| format | Article |
| id | doaj-art-b1f1ae1a683a416a9ae79ef81780a000 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-b1f1ae1a683a416a9ae79ef81780a0002025-01-22T09:49:06ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011610.3389/fphar.2025.15110831511083Baicalin: a potential therapeutic agent for acute kidney injury and renal fibrosisXiaoming Li0Xiaoming Li1Rui Xu2Rui Xu3Dan Zhang4Ji Cai5Ji Cai6He Zhou7He Zhou8Tao Song9Tao Song10Xianyao Wang11Xianyao Wang12Qinghong Kong13Liujin Li14Zhaohui Liu15Zhixu He16Zhengzhen Tang17Jun Tan18Jidong Zhang19Jidong Zhang20Jidong Zhang21Department of Immunology, Zunyi Medical University, Zunyi, ChinaSpecial Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi, ChinaSpecial Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi, ChinaZunyi Medical University Library Administrative Office, Zunyi, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi, ChinaSpecial Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi, ChinaSpecial Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi, ChinaSpecial Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi, ChinaSpecial Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi, ChinaGuizhou Provincial College-Based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, ChinaDepartment of Otolaryngology, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Otolaryngology, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaCollaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine, Zunyi Medical University, Zunyi, ChinaDepartment of Pediatrics, The First People’s Hospital of Zunyi, Third Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Histology and Embryology, Zunyi Medical University, Zunyi, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi, ChinaSpecial Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi, ChinaCollaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine, Zunyi Medical University, Zunyi, ChinaAcute kidney injury (AKI) is a common critical clinical disease that is linked to significant morbidity, recurrence, and mortality. It is characterized by a fast and prolonged loss in renal function arising from numerous etiologies and pathogenic pathways. Renal fibrosis, defined as the excessive accumulation of collagen and proliferation of fibroblasts within renal tissues, contributes to the structural damage and functional decline of the kidneys, playing a pivotal role in the advancement of Chronic Kidney Disease (CKD). Until now, while continuous renal replacement therapy (CRRT) has been utilized in the management of severe AKI, there remains a dearth of effective targeted therapies for AKI stemming from diverse etiologies. Similarly, the identification of specific biomarkers and pharmacological targets for the treatment of renal fibrosis remains a challenge. Baicalin, a naturally occurring compound classified within the flavonoid group and commonly found in the Chinese herb Scutellaria baicalensis, has shown a range of pharmacological characteristics, such as antioxidant, anti-inflammatory, antifibrotic, antitumor and antiviral effects, as evidenced by research studies. Research shows that Baicalin has potential in treating kidney diseases like AKI and renal fibrosis. This review aims to summarize Baicalin’s progress in these areas, including its molecular mechanism, application in treatment, and absorption, distribution, metabolism, and excretion. Baicalin’s therapeutic effects are achieved through various pathways, including antioxidant, anti-inflammatory, antifibrosis, and regulation of apoptosis and cell proliferation. Besides, we also hope this review may give some enlightenment for treating AKI and renal fibrosis in clinical practice.https://www.frontiersin.org/articles/10.3389/fphar.2025.1511083/fullacute kidney injuryrenal fibrosisherbal medicinebaicalinmechanism |
| spellingShingle | Xiaoming Li Xiaoming Li Rui Xu Rui Xu Dan Zhang Ji Cai Ji Cai He Zhou He Zhou Tao Song Tao Song Xianyao Wang Xianyao Wang Qinghong Kong Liujin Li Zhaohui Liu Zhixu He Zhengzhen Tang Jun Tan Jidong Zhang Jidong Zhang Jidong Zhang Baicalin: a potential therapeutic agent for acute kidney injury and renal fibrosis Frontiers in Pharmacology acute kidney injury renal fibrosis herbal medicine baicalin mechanism |
| title | Baicalin: a potential therapeutic agent for acute kidney injury and renal fibrosis |
| title_full | Baicalin: a potential therapeutic agent for acute kidney injury and renal fibrosis |
| title_fullStr | Baicalin: a potential therapeutic agent for acute kidney injury and renal fibrosis |
| title_full_unstemmed | Baicalin: a potential therapeutic agent for acute kidney injury and renal fibrosis |
| title_short | Baicalin: a potential therapeutic agent for acute kidney injury and renal fibrosis |
| title_sort | baicalin a potential therapeutic agent for acute kidney injury and renal fibrosis |
| topic | acute kidney injury renal fibrosis herbal medicine baicalin mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1511083/full |
| work_keys_str_mv | AT xiaomingli baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT xiaomingli baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT ruixu baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT ruixu baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT danzhang baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT jicai baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT jicai baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT hezhou baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT hezhou baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT taosong baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT taosong baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT xianyaowang baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT xianyaowang baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT qinghongkong baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT liujinli baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT zhaohuiliu baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT zhixuhe baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT zhengzhentang baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT juntan baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT jidongzhang baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT jidongzhang baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis AT jidongzhang baicalinapotentialtherapeuticagentforacutekidneyinjuryandrenalfibrosis |