Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis
Background and Aims. It is widely accepted that obstructive sleep apnea (OSA) is independently associated with atherosclerosis. Similar to OSA, hypertension (HTN) is a condition associated with atherosclerosis. However, to date, the impact of the simultaneous presence of OSA and HTN on the risk of a...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2015/984193 |
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| author | Mario Francesco Damiani Annapaola Zito Pierluigi Carratù Vito Antonio Falcone Elioda Bega Pietro Scicchitano Marco Matteo Ciccone Onofrio Resta |
| author_facet | Mario Francesco Damiani Annapaola Zito Pierluigi Carratù Vito Antonio Falcone Elioda Bega Pietro Scicchitano Marco Matteo Ciccone Onofrio Resta |
| author_sort | Mario Francesco Damiani |
| collection | DOAJ |
| description | Background and Aims. It is widely accepted that obstructive sleep apnea (OSA) is independently associated with atherosclerosis. Similar to OSA, hypertension (HTN) is a condition associated with atherosclerosis. However, to date, the impact of the simultaneous presence of OSA and HTN on the risk of atherosclerosis has not been extensively studied. The aim of this study was to evaluate the consequences of the coexistence of OSA and HTN on carotid intima-media thickness (IMT) and on inflammatory markers of atherosclerosis (such as interleukin- [IL-] 6 and pentraxin- [PTX-] 3). Methods. The study design allowed us to define 4 groups: (1) controls (n=30); (2) OSA patients without HTN (n=30); (3) HTN patients without OSA (n=30); (4) patients with OSA and HTN (n=30). In the morning after portable monitoring (between 7 am and 8 am), blood samples were collected, and carotid IMT was measured. Results. Carotid IMT, IL-6, and PTX-3 in OSA normotensive patients and in non-OSA HTN subjects were significantly higher compared to control subjects; in addition, in OSA hypertensive patients they were significantly increased compared to OSA normotensive, non-OSA HTN, or control subjects. Conclusions. OSA and HTN have an additive role in the progression of carotid atherosclerosis and in blood levels of inflammatory markers for atherosclerosis, such as interleukin-6 and pentraxin-3. |
| format | Article |
| id | doaj-art-b1dd055e8875481c8e3cbc8467a8aa77 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-b1dd055e8875481c8e3cbc8467a8aa772025-02-03T05:51:59ZengWileyBiochemistry Research International2090-22472090-22552015-01-01201510.1155/2015/984193984193Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on AtherosclerosisMario Francesco Damiani0Annapaola Zito1Pierluigi Carratù2Vito Antonio Falcone3Elioda Bega4Pietro Scicchitano5Marco Matteo Ciccone6Onofrio Resta7Institute of Respiratory Disease, University of Bari, Bari, ItalySection of Cardiovascular Disease, University of Bari, Bari, ItalyInstitute of Respiratory Disease, University of Bari, Bari, ItalyInstitute of Respiratory Disease, University of Bari, Bari, ItalyInstitute of Respiratory Disease, University of Bari, Bari, ItalySection of Cardiovascular Disease, University of Bari, Bari, ItalySection of Cardiovascular Disease, University of Bari, Bari, ItalyInstitute of Respiratory Disease, University of Bari, Bari, ItalyBackground and Aims. It is widely accepted that obstructive sleep apnea (OSA) is independently associated with atherosclerosis. Similar to OSA, hypertension (HTN) is a condition associated with atherosclerosis. However, to date, the impact of the simultaneous presence of OSA and HTN on the risk of atherosclerosis has not been extensively studied. The aim of this study was to evaluate the consequences of the coexistence of OSA and HTN on carotid intima-media thickness (IMT) and on inflammatory markers of atherosclerosis (such as interleukin- [IL-] 6 and pentraxin- [PTX-] 3). Methods. The study design allowed us to define 4 groups: (1) controls (n=30); (2) OSA patients without HTN (n=30); (3) HTN patients without OSA (n=30); (4) patients with OSA and HTN (n=30). In the morning after portable monitoring (between 7 am and 8 am), blood samples were collected, and carotid IMT was measured. Results. Carotid IMT, IL-6, and PTX-3 in OSA normotensive patients and in non-OSA HTN subjects were significantly higher compared to control subjects; in addition, in OSA hypertensive patients they were significantly increased compared to OSA normotensive, non-OSA HTN, or control subjects. Conclusions. OSA and HTN have an additive role in the progression of carotid atherosclerosis and in blood levels of inflammatory markers for atherosclerosis, such as interleukin-6 and pentraxin-3.http://dx.doi.org/10.1155/2015/984193 |
| spellingShingle | Mario Francesco Damiani Annapaola Zito Pierluigi Carratù Vito Antonio Falcone Elioda Bega Pietro Scicchitano Marco Matteo Ciccone Onofrio Resta Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis Biochemistry Research International |
| title | Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis |
| title_full | Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis |
| title_fullStr | Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis |
| title_full_unstemmed | Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis |
| title_short | Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis |
| title_sort | obstructive sleep apnea hypertension and their additive effects on atherosclerosis |
| url | http://dx.doi.org/10.1155/2015/984193 |
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