Telephone-Based Reeducation of Drug Administration for Helicobacterpylori Eradication: A Multicenter Randomized Controlled Study
Poor adherence to treatment instructions may play an important role in the failure of Helicobacter pylori eradication. The aim of this study was to evaluate the effects of telephone-based reeducation on 14-day quadruple H. pylori eradication therapy. In total, 162 patients were randomly assigned (1 ...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/8972473 |
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| author | Yan Zhao Mudan Ren Xin Wang Guifang Lu Xinlan Lu Dan Zhang Shuixiang He |
| author_facet | Yan Zhao Mudan Ren Xin Wang Guifang Lu Xinlan Lu Dan Zhang Shuixiang He |
| author_sort | Yan Zhao |
| collection | DOAJ |
| description | Poor adherence to treatment instructions may play an important role in the failure of Helicobacter pylori eradication. The aim of this study was to evaluate the effects of telephone-based reeducation on 14-day quadruple H. pylori eradication therapy. In total, 162 patients were randomly assigned (1 : 1) to either the intervention group (patients received telephone-based reeducation on the 4th, 7th, and 10th days of the course) or the control group (patients received instructions only at the time of getting the prescriptions). All patients received a 14-day quadruple H. pylori eradication therapy. The primary outcome was the H. pylori eradication rate. The secondary outcomes included the symptom relief rates and the incidence rates of adverse events. Seventy-five patients in the reeducation group and 74 patients in the control group completed the follow-up. The H. pylori eradication rate in the reeducation group was statistically higher than that in the control group (intention-to-treat: 72.8% vs. 50.6%, P=0.006; per-protocol: 78.7% vs. 55.4%, P=0.003). However, the symptom relief rates and the adverse event rates in these two groups were not significantly different. Overall, the results from this study suggest that telephone-based reeducation can be potentially applied to improve the H. pylori eradication rate in clinical practice, without significantly increasing the adverse effects. |
| format | Article |
| id | doaj-art-b1d43f8423e04d9ba65128f04cd565bf |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-b1d43f8423e04d9ba65128f04cd565bf2025-02-03T05:44:12ZengWileyGastroenterology Research and Practice1687-61211687-630X2020-01-01202010.1155/2020/89724738972473Telephone-Based Reeducation of Drug Administration for Helicobacterpylori Eradication: A Multicenter Randomized Controlled StudyYan Zhao0Mudan Ren1Xin Wang2Guifang Lu3Xinlan Lu4Dan Zhang5Shuixiang He6Department of Gastroenterology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaPoor adherence to treatment instructions may play an important role in the failure of Helicobacter pylori eradication. The aim of this study was to evaluate the effects of telephone-based reeducation on 14-day quadruple H. pylori eradication therapy. In total, 162 patients were randomly assigned (1 : 1) to either the intervention group (patients received telephone-based reeducation on the 4th, 7th, and 10th days of the course) or the control group (patients received instructions only at the time of getting the prescriptions). All patients received a 14-day quadruple H. pylori eradication therapy. The primary outcome was the H. pylori eradication rate. The secondary outcomes included the symptom relief rates and the incidence rates of adverse events. Seventy-five patients in the reeducation group and 74 patients in the control group completed the follow-up. The H. pylori eradication rate in the reeducation group was statistically higher than that in the control group (intention-to-treat: 72.8% vs. 50.6%, P=0.006; per-protocol: 78.7% vs. 55.4%, P=0.003). However, the symptom relief rates and the adverse event rates in these two groups were not significantly different. Overall, the results from this study suggest that telephone-based reeducation can be potentially applied to improve the H. pylori eradication rate in clinical practice, without significantly increasing the adverse effects.http://dx.doi.org/10.1155/2020/8972473 |
| spellingShingle | Yan Zhao Mudan Ren Xin Wang Guifang Lu Xinlan Lu Dan Zhang Shuixiang He Telephone-Based Reeducation of Drug Administration for Helicobacterpylori Eradication: A Multicenter Randomized Controlled Study Gastroenterology Research and Practice |
| title | Telephone-Based Reeducation of Drug Administration for Helicobacterpylori Eradication: A Multicenter Randomized Controlled Study |
| title_full | Telephone-Based Reeducation of Drug Administration for Helicobacterpylori Eradication: A Multicenter Randomized Controlled Study |
| title_fullStr | Telephone-Based Reeducation of Drug Administration for Helicobacterpylori Eradication: A Multicenter Randomized Controlled Study |
| title_full_unstemmed | Telephone-Based Reeducation of Drug Administration for Helicobacterpylori Eradication: A Multicenter Randomized Controlled Study |
| title_short | Telephone-Based Reeducation of Drug Administration for Helicobacterpylori Eradication: A Multicenter Randomized Controlled Study |
| title_sort | telephone based reeducation of drug administration for helicobacterpylori eradication a multicenter randomized controlled study |
| url | http://dx.doi.org/10.1155/2020/8972473 |
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