The association between upper tarsal conjunctiva appearance and corneal biomechanical weakening in refractive surgery candidates
Abstract Current evidence suggests allergic conjunctivitis and contact lens use may affect corneal biomechanics, but the relationship between conjunctival changes and biomechanical abnormalities remains unclear. This study aimed to determine whether upper tarsal conjunctival roughness and redness ar...
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Nature Portfolio
2025-04-01
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| Online Access: | https://doi.org/10.1038/s41598-025-00122-2 |
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| author | Phit Upaphong Napaporn Tananuvat Muanploy Niparugs Janejit Choovuthayakorn Chulaluck Tangmonkongvoragul Somsanguan Ausayakhun Winai Chaidaroon |
| author_facet | Phit Upaphong Napaporn Tananuvat Muanploy Niparugs Janejit Choovuthayakorn Chulaluck Tangmonkongvoragul Somsanguan Ausayakhun Winai Chaidaroon |
| author_sort | Phit Upaphong |
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| description | Abstract Current evidence suggests allergic conjunctivitis and contact lens use may affect corneal biomechanics, but the relationship between conjunctival changes and biomechanical abnormalities remains unclear. This study aimed to determine whether upper tarsal conjunctival roughness and redness are associated with corneal biomechanical weakening in refractive surgery candidates without ectatic corneal disease. Conducted at Chiang Mai University LASIK Center between July 2023 and January 2024, conjunctival roughness and redness were graded using the Institute for Eye Research (IER) scales, while corneal biomechanics were assessed through Corvis parameters. The study included 434 eyes from 217 participants (70.5% female), with a mean age of 33.4 years (SD 8.3). Ocular allergy was reported by 23.0% (50/217) of participants, and 54.4% (236/434) had a history of contact lens use. The median conjunctival roughness score was 2 (IQR 0, 5). Conjunctival roughness score was positively correlated with biomechanical indices, particularly the deformation amplitude (DA) ratio (coefficient 0.009, 95% confidence interval 0.001 to 0.017, p = .04), suggesting weakened biomechanical property. No significant association was found between conjunctival redness and corneal biomechanics. In conclusion, upper tarsal roughness may associate with biomechanical weakening of the cornea, though these changes were insufficient to significantly affect the Corvis Biomechanical Index (CBI). |
| format | Article |
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| institution | DOAJ |
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| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-b1d1667d8f5c49c7b1f2c99b9fec8bda2025-08-20T02:55:38ZengNature PortfolioScientific Reports2045-23222025-04-011511810.1038/s41598-025-00122-2The association between upper tarsal conjunctiva appearance and corneal biomechanical weakening in refractive surgery candidatesPhit Upaphong0Napaporn Tananuvat1Muanploy Niparugs2Janejit Choovuthayakorn3Chulaluck Tangmonkongvoragul4Somsanguan Ausayakhun5Winai Chaidaroon6Department of Ophthalmology, Faculty of Medicine, Chiang Mai UniversityDepartment of Ophthalmology, Faculty of Medicine, Chiang Mai UniversityDepartment of Ophthalmology, Faculty of Medicine, Chiang Mai UniversityDepartment of Ophthalmology, Faculty of Medicine, Chiang Mai UniversityDepartment of Ophthalmology, Faculty of Medicine, Chiang Mai UniversityDepartment of Ophthalmology, Faculty of Medicine, Chiang Mai UniversityDepartment of Ophthalmology, Faculty of Medicine, Chiang Mai UniversityAbstract Current evidence suggests allergic conjunctivitis and contact lens use may affect corneal biomechanics, but the relationship between conjunctival changes and biomechanical abnormalities remains unclear. This study aimed to determine whether upper tarsal conjunctival roughness and redness are associated with corneal biomechanical weakening in refractive surgery candidates without ectatic corneal disease. Conducted at Chiang Mai University LASIK Center between July 2023 and January 2024, conjunctival roughness and redness were graded using the Institute for Eye Research (IER) scales, while corneal biomechanics were assessed through Corvis parameters. The study included 434 eyes from 217 participants (70.5% female), with a mean age of 33.4 years (SD 8.3). Ocular allergy was reported by 23.0% (50/217) of participants, and 54.4% (236/434) had a history of contact lens use. The median conjunctival roughness score was 2 (IQR 0, 5). Conjunctival roughness score was positively correlated with biomechanical indices, particularly the deformation amplitude (DA) ratio (coefficient 0.009, 95% confidence interval 0.001 to 0.017, p = .04), suggesting weakened biomechanical property. No significant association was found between conjunctival redness and corneal biomechanics. In conclusion, upper tarsal roughness may associate with biomechanical weakening of the cornea, though these changes were insufficient to significantly affect the Corvis Biomechanical Index (CBI).https://doi.org/10.1038/s41598-025-00122-2Allergic conjunctivitisConjunctival roughnessCorneal deformation dynamicsEctasiaEctatic corneal diseasePapillae |
| spellingShingle | Phit Upaphong Napaporn Tananuvat Muanploy Niparugs Janejit Choovuthayakorn Chulaluck Tangmonkongvoragul Somsanguan Ausayakhun Winai Chaidaroon The association between upper tarsal conjunctiva appearance and corneal biomechanical weakening in refractive surgery candidates Scientific Reports Allergic conjunctivitis Conjunctival roughness Corneal deformation dynamics Ectasia Ectatic corneal disease Papillae |
| title | The association between upper tarsal conjunctiva appearance and corneal biomechanical weakening in refractive surgery candidates |
| title_full | The association between upper tarsal conjunctiva appearance and corneal biomechanical weakening in refractive surgery candidates |
| title_fullStr | The association between upper tarsal conjunctiva appearance and corneal biomechanical weakening in refractive surgery candidates |
| title_full_unstemmed | The association between upper tarsal conjunctiva appearance and corneal biomechanical weakening in refractive surgery candidates |
| title_short | The association between upper tarsal conjunctiva appearance and corneal biomechanical weakening in refractive surgery candidates |
| title_sort | association between upper tarsal conjunctiva appearance and corneal biomechanical weakening in refractive surgery candidates |
| topic | Allergic conjunctivitis Conjunctival roughness Corneal deformation dynamics Ectasia Ectatic corneal disease Papillae |
| url | https://doi.org/10.1038/s41598-025-00122-2 |
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