Neuromodulation with chemicals: Opportunities and challenges
Chemicals play a crucial role in neurophysiological and neuropathological processes. By regulating the concentration of specific chemicals, receptors on the neuron cell membrane can be modulated to activate or inhibit, thereby influencing specific ion channels and facilitating neuromodulation. This...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2025-01-01
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| Series: | Fundamental Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325824001547 |
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| author | Yifei Pan Cong Pan Lanqun Mao Ping Yu |
| author_facet | Yifei Pan Cong Pan Lanqun Mao Ping Yu |
| author_sort | Yifei Pan |
| collection | DOAJ |
| description | Chemicals play a crucial role in neurophysiological and neuropathological processes. By regulating the concentration of specific chemicals, receptors on the neuron cell membrane can be modulated to activate or inhibit, thereby influencing specific ion channels and facilitating neuromodulation. This review introduces several chemical modulation techniques, such as microinjection, electrode/nanoparticle-based chemical delivery methods, in situ electrochemical synthesis and chemogenetics. While these techniques show promise in expanding the application of chemical neuromodulation, they currently exhibit different degrees of shortcomings and room for improvement. This review summarizes the opportunities and challenges for chemical neuromodulation methods and provide an outlook for their prospects in the future. |
| format | Article |
| id | doaj-art-b1d081f9eed149cdbc0c4e56860cd468 |
| institution | Kabale University |
| issn | 2667-3258 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj-art-b1d081f9eed149cdbc0c4e56860cd4682025-01-29T05:02:36ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582025-01-01515562Neuromodulation with chemicals: Opportunities and challengesYifei Pan0Cong Pan1Lanqun Mao2Ping Yu3Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, ChinaKey Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, ChinaCollege of Chemistry, Beijing Normal University, Beijing 100875, ChinaKey Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; Corresponding author.Chemicals play a crucial role in neurophysiological and neuropathological processes. By regulating the concentration of specific chemicals, receptors on the neuron cell membrane can be modulated to activate or inhibit, thereby influencing specific ion channels and facilitating neuromodulation. This review introduces several chemical modulation techniques, such as microinjection, electrode/nanoparticle-based chemical delivery methods, in situ electrochemical synthesis and chemogenetics. While these techniques show promise in expanding the application of chemical neuromodulation, they currently exhibit different degrees of shortcomings and room for improvement. This review summarizes the opportunities and challenges for chemical neuromodulation methods and provide an outlook for their prospects in the future.http://www.sciencedirect.com/science/article/pii/S2667325824001547NeuromodulationChemical deliveryBrain chemistryNeurochemistryIn vivo |
| spellingShingle | Yifei Pan Cong Pan Lanqun Mao Ping Yu Neuromodulation with chemicals: Opportunities and challenges Fundamental Research Neuromodulation Chemical delivery Brain chemistry Neurochemistry In vivo |
| title | Neuromodulation with chemicals: Opportunities and challenges |
| title_full | Neuromodulation with chemicals: Opportunities and challenges |
| title_fullStr | Neuromodulation with chemicals: Opportunities and challenges |
| title_full_unstemmed | Neuromodulation with chemicals: Opportunities and challenges |
| title_short | Neuromodulation with chemicals: Opportunities and challenges |
| title_sort | neuromodulation with chemicals opportunities and challenges |
| topic | Neuromodulation Chemical delivery Brain chemistry Neurochemistry In vivo |
| url | http://www.sciencedirect.com/science/article/pii/S2667325824001547 |
| work_keys_str_mv | AT yifeipan neuromodulationwithchemicalsopportunitiesandchallenges AT congpan neuromodulationwithchemicalsopportunitiesandchallenges AT lanqunmao neuromodulationwithchemicalsopportunitiesandchallenges AT pingyu neuromodulationwithchemicalsopportunitiesandchallenges |