Cryopreserved leukapheresis enables scalable and distributed CAR-T manufacturing: a multi-platform comparative study

Cryopreserved leukapheresis enables scalable and distributed CAR-T manufacturing: a multi-platform comparative study

Abstract Cryopreserved leukapheresis is a scalable source for Chimeric antigen receptor T (CAR-T) manufacturing, yet it remains understudied (18.3% of 349 studies, 2010–2024). Current challenges include that cryopreserved leukapheresis lacks a standardized preparation process and has a low level of...

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Bibliographic Details
Main Authors: Menglin Ren, Xiaodie Wang, Jiangrui Chen, Yuanjian Xu, Yan Sun, Tao Liu, Qijun Qian, Zenghui Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Cryopreserved leukapheresis
PBMCs
CAR-T
Fast CAR-T
Online Access:https://doi.org/10.1038/s41598-025-14865-5
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