In vitro and in silico evaluation of phytocompounds from Leucaena leucocephala and Entada phaseoloides targeting DNA gyrase, topoisomerase II, AKT1

In vitro and in silico evaluation of phytocompounds from Leucaena leucocephala and Entada phaseoloides targeting DNA gyrase, topoisomerase II, AKT1

Abstract Medicinal plants are rich in bioactive phytochemicals with the potential to treat various ailments, including cancer and infectious diseases. Leucaena leucocephala and Entada phaseoloides have long been used in traditional medicine for such conditions. This study investigated the phytochemi...

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Bibliographic Details
Main Authors: Laldinliana Khiangte, Hmingremhlua Sailo, Laldinfeli Ralte, F. Lalnunmawia, N. Senthilkumar, Yengkhom Tunginba Singh
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Leucaena leucocephala
Entada phaseoloides
Cytotoxicity
Molecular docking
Network pharmacology
FTIR
Online Access:https://doi.org/10.1038/s41598-025-07792-y
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