B Cell Responses to CpG Correlate with CXCL16 Expression Levels in Common Variable Immunodeficiency
Broad Toll-like receptor 9 (TLR9) signalling defects after CpG in vitro stimulation have been described in common variable immunodeficiency (CVID). CXCL16, a surface receptor, was recently shown to influence cell responses to CpG. We evaluated the expression and function of CXCL16 on B cells from he...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/960219 |
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| _version_ | 1832553491996868608 |
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| author | Vassilios Lougaris Manuela Baronio Massimiliano Vitali Giacomo Tampella Annarosa Soresina Raffaele Badolato Alessandro Plebani |
| author_facet | Vassilios Lougaris Manuela Baronio Massimiliano Vitali Giacomo Tampella Annarosa Soresina Raffaele Badolato Alessandro Plebani |
| author_sort | Vassilios Lougaris |
| collection | DOAJ |
| description | Broad Toll-like receptor 9 (TLR9) signalling defects after CpG in vitro stimulation have been described in common variable immunodeficiency (CVID). CXCL16, a surface receptor, was recently shown to influence cell responses to CpG. We evaluated the expression and function of CXCL16 on B cells from healthy controls and CVID patients. We report that CXCL16 is normally expressed on B cells throughout peripheral maturation. Decreased B cell expression of CXCL16 was observed in a subgroup of CVID patients that correlated with defective in vitro responses to CpG (such as upregulation of CD69, CD86, AICDA, IL-6, and TLR9). Our data suggest that expression levels of a surface receptor, namely, CXCL16, correlate with B cell responses mediated by TLR9 in common variable immunodeficiency. |
| format | Article |
| id | doaj-art-b1b48c1d28494c2aad0fa40bc611674f |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-b1b48c1d28494c2aad0fa40bc611674f2025-02-03T05:53:55ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/960219960219B Cell Responses to CpG Correlate with CXCL16 Expression Levels in Common Variable ImmunodeficiencyVassilios Lougaris0Manuela Baronio1Massimiliano Vitali2Giacomo Tampella3Annarosa Soresina4Raffaele Badolato5Alessandro Plebani6Pediatrics Clinic and Institute of Molecular Medicine “A. Nocivelli”, University of Brescia, piazzale Spedali Civili 1, 25123 Brescia, ItalyPediatrics Clinic and Institute of Molecular Medicine “A. Nocivelli”, University of Brescia, piazzale Spedali Civili 1, 25123 Brescia, ItalyPediatrics Clinic and Institute of Molecular Medicine “A. Nocivelli”, University of Brescia, piazzale Spedali Civili 1, 25123 Brescia, ItalyPediatrics Clinic and Institute of Molecular Medicine “A. Nocivelli”, University of Brescia, piazzale Spedali Civili 1, 25123 Brescia, ItalyPediatrics Clinic and Institute of Molecular Medicine “A. Nocivelli”, University of Brescia, piazzale Spedali Civili 1, 25123 Brescia, ItalyPediatrics Clinic and Institute of Molecular Medicine “A. Nocivelli”, University of Brescia, piazzale Spedali Civili 1, 25123 Brescia, ItalyPediatrics Clinic and Institute of Molecular Medicine “A. Nocivelli”, University of Brescia, piazzale Spedali Civili 1, 25123 Brescia, ItalyBroad Toll-like receptor 9 (TLR9) signalling defects after CpG in vitro stimulation have been described in common variable immunodeficiency (CVID). CXCL16, a surface receptor, was recently shown to influence cell responses to CpG. We evaluated the expression and function of CXCL16 on B cells from healthy controls and CVID patients. We report that CXCL16 is normally expressed on B cells throughout peripheral maturation. Decreased B cell expression of CXCL16 was observed in a subgroup of CVID patients that correlated with defective in vitro responses to CpG (such as upregulation of CD69, CD86, AICDA, IL-6, and TLR9). Our data suggest that expression levels of a surface receptor, namely, CXCL16, correlate with B cell responses mediated by TLR9 in common variable immunodeficiency.http://dx.doi.org/10.1100/2012/960219 |
| spellingShingle | Vassilios Lougaris Manuela Baronio Massimiliano Vitali Giacomo Tampella Annarosa Soresina Raffaele Badolato Alessandro Plebani B Cell Responses to CpG Correlate with CXCL16 Expression Levels in Common Variable Immunodeficiency The Scientific World Journal |
| title | B Cell Responses to CpG Correlate with CXCL16 Expression Levels in Common Variable Immunodeficiency |
| title_full | B Cell Responses to CpG Correlate with CXCL16 Expression Levels in Common Variable Immunodeficiency |
| title_fullStr | B Cell Responses to CpG Correlate with CXCL16 Expression Levels in Common Variable Immunodeficiency |
| title_full_unstemmed | B Cell Responses to CpG Correlate with CXCL16 Expression Levels in Common Variable Immunodeficiency |
| title_short | B Cell Responses to CpG Correlate with CXCL16 Expression Levels in Common Variable Immunodeficiency |
| title_sort | b cell responses to cpg correlate with cxcl16 expression levels in common variable immunodeficiency |
| url | http://dx.doi.org/10.1100/2012/960219 |
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