Serotonin circuits act cooperatively with pathophysiology of opioid use disorder
Opioid abuse and its negative effect have become a critical epidemic, putting our health and society in jeopardy. Opioids are effective treatment for pain, but at risk for developing associated health threatening impacts including the euphoria associated relapsing effects, persistent occurrence with...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Addiction Neuroscience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772392524000464 |
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| _version_ | 1832583045020909568 |
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| author | Arakawa Hiroyuki Ozawa Akihiko |
| author_facet | Arakawa Hiroyuki Ozawa Akihiko |
| author_sort | Arakawa Hiroyuki |
| collection | DOAJ |
| description | Opioid abuse and its negative effect have become a critical epidemic, putting our health and society in jeopardy. Opioids are effective treatment for pain, but at risk for developing associated health threatening impacts including the euphoria associated relapsing effects, persistent occurrence with addictive and withdrawal symptoms, and consequent respiratory depression and apnea. The opioid use disorder (OUD), represented as those recurring phases of symptoms, is initiated with mediation of opioid receptor signaling pathway and subsequent neurocircuitry transformation with homeostatic and motivational change. It has been imperative to establish modulatory mechanisms and alternative treatments to mitigate OUD. This review deals with central serotonin (5-HT) system as a cooperative mediator with OUD-related neural processing. We briefly introduce molecular base of opioid receptors and available research tools in mouse models and examine OUD-phase dependent circuit mechanisms, including pain, addiction, and respiratory depression. We interrogate the potential neural roles of 5-HT in OUD-related symptoms including 5-HT toxicity and pathophysiology and discuss potential availability of 5-HT-related agents as a neuromodulatory therapeutic interacting with opioid mediated neural mechanisms and the OUD-related symptoms. |
| format | Article |
| id | doaj-art-b1a0f6c73efc4a97873d9d72d3cac683 |
| institution | Kabale University |
| issn | 2772-3925 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Addiction Neuroscience |
| spelling | doaj-art-b1a0f6c73efc4a97873d9d72d3cac6832025-01-29T05:02:41ZengElsevierAddiction Neuroscience2772-39252025-03-0114100187Serotonin circuits act cooperatively with pathophysiology of opioid use disorderArakawa Hiroyuki0Ozawa Akihiko1Edward F Domino Research Center, Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, MI, USA; Corresponding author at: Edward F Domino Research Center, Department of Pharmacology, University of Michigan School of Medicine, 1150 W Medical Center Dr. Medical Sciences Research Building III, Ann Arbor, Michigan, 48109, USA.Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USAOpioid abuse and its negative effect have become a critical epidemic, putting our health and society in jeopardy. Opioids are effective treatment for pain, but at risk for developing associated health threatening impacts including the euphoria associated relapsing effects, persistent occurrence with addictive and withdrawal symptoms, and consequent respiratory depression and apnea. The opioid use disorder (OUD), represented as those recurring phases of symptoms, is initiated with mediation of opioid receptor signaling pathway and subsequent neurocircuitry transformation with homeostatic and motivational change. It has been imperative to establish modulatory mechanisms and alternative treatments to mitigate OUD. This review deals with central serotonin (5-HT) system as a cooperative mediator with OUD-related neural processing. We briefly introduce molecular base of opioid receptors and available research tools in mouse models and examine OUD-phase dependent circuit mechanisms, including pain, addiction, and respiratory depression. We interrogate the potential neural roles of 5-HT in OUD-related symptoms including 5-HT toxicity and pathophysiology and discuss potential availability of 5-HT-related agents as a neuromodulatory therapeutic interacting with opioid mediated neural mechanisms and the OUD-related symptoms.http://www.sciencedirect.com/science/article/pii/S2772392524000464Opioid receptorsSerotoninPainAddictionWithdrawalRespiratory depression |
| spellingShingle | Arakawa Hiroyuki Ozawa Akihiko Serotonin circuits act cooperatively with pathophysiology of opioid use disorder Addiction Neuroscience Opioid receptors Serotonin Pain Addiction Withdrawal Respiratory depression |
| title | Serotonin circuits act cooperatively with pathophysiology of opioid use disorder |
| title_full | Serotonin circuits act cooperatively with pathophysiology of opioid use disorder |
| title_fullStr | Serotonin circuits act cooperatively with pathophysiology of opioid use disorder |
| title_full_unstemmed | Serotonin circuits act cooperatively with pathophysiology of opioid use disorder |
| title_short | Serotonin circuits act cooperatively with pathophysiology of opioid use disorder |
| title_sort | serotonin circuits act cooperatively with pathophysiology of opioid use disorder |
| topic | Opioid receptors Serotonin Pain Addiction Withdrawal Respiratory depression |
| url | http://www.sciencedirect.com/science/article/pii/S2772392524000464 |
| work_keys_str_mv | AT arakawahiroyuki serotonincircuitsactcooperativelywithpathophysiologyofopioidusedisorder AT ozawaakihiko serotonincircuitsactcooperativelywithpathophysiologyofopioidusedisorder |