Platelet Counts and Liver Enzymes after Bariatric Surgery
Background. Obesity is characterized by liver steatosis, chronic inflammation, and increased liver enzymes, that is, gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT), markers for nonalcoholic fatty liver disease (NAFLD) and liver fat content. Increased platelet counts (PCs) are ass...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2013/567984 |
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| author | Hans-Erik Johansson Arvo Haenni Björn Zethelius |
| author_facet | Hans-Erik Johansson Arvo Haenni Björn Zethelius |
| author_sort | Hans-Erik Johansson |
| collection | DOAJ |
| description | Background. Obesity is characterized by liver steatosis, chronic inflammation, and increased liver enzymes, that is, gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT), markers for nonalcoholic fatty liver disease (NAFLD) and liver fat content. Increased platelet counts (PCs) are associated with inflammatory conditions and are a valuable biomarker of the degree of fibrosis in NAFLD. We investigated alterations in PC, GGT, and ALT after biliopancreatic diversion with duodenal switch (BPD-DS) and Roux-en-Y gastric bypass (RYGBP). Methods. Ten morbidly obese patients (body mass index, BMI: 53.5±3.8 kg/m2) who underwent BPD-DS were evaluated preoperatively (baseline) and 1 year (1st followup) and 3 years (2nd followup) after surgery and compared with 21 morbidly obese patients (BMI: 42.3±5.2 kg/m2) who underwent RYGBP. Results. Over the 3 years of followup, changes in BPD-DS and RYGBP patients (BPD-DS/RYGBP) were as follows: BMI (−44%/−24%), GGT (−63%/−52%), and ALT (−48%/−62%). PC decreased (−21%) statistically significantly only in BPD-DS patients. Conclusions. Morbidly obese patients treated by RYGBP or BPD-DS show sustained reductions in BMI, ALT, and GGT. The decrease in PC and liver enzymes after BPD-DS may reflect a more pronounced decrease of liver-fat-content-related inflammation and, as a result, a lowered secondary thrombocytosis. |
| format | Article |
| id | doaj-art-b18cbfdbc9ef468a9c2eb0950301f0d0 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-b18cbfdbc9ef468a9c2eb0950301f0d02025-02-03T06:12:12ZengWileyJournal of Obesity2090-07082090-07162013-01-01201310.1155/2013/567984567984Platelet Counts and Liver Enzymes after Bariatric SurgeryHans-Erik Johansson0Arvo Haenni1Björn Zethelius2Section of Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, 75185 Uppsala, SwedenSection of Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, 75185 Uppsala, SwedenSection of Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, 75185 Uppsala, SwedenBackground. Obesity is characterized by liver steatosis, chronic inflammation, and increased liver enzymes, that is, gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT), markers for nonalcoholic fatty liver disease (NAFLD) and liver fat content. Increased platelet counts (PCs) are associated with inflammatory conditions and are a valuable biomarker of the degree of fibrosis in NAFLD. We investigated alterations in PC, GGT, and ALT after biliopancreatic diversion with duodenal switch (BPD-DS) and Roux-en-Y gastric bypass (RYGBP). Methods. Ten morbidly obese patients (body mass index, BMI: 53.5±3.8 kg/m2) who underwent BPD-DS were evaluated preoperatively (baseline) and 1 year (1st followup) and 3 years (2nd followup) after surgery and compared with 21 morbidly obese patients (BMI: 42.3±5.2 kg/m2) who underwent RYGBP. Results. Over the 3 years of followup, changes in BPD-DS and RYGBP patients (BPD-DS/RYGBP) were as follows: BMI (−44%/−24%), GGT (−63%/−52%), and ALT (−48%/−62%). PC decreased (−21%) statistically significantly only in BPD-DS patients. Conclusions. Morbidly obese patients treated by RYGBP or BPD-DS show sustained reductions in BMI, ALT, and GGT. The decrease in PC and liver enzymes after BPD-DS may reflect a more pronounced decrease of liver-fat-content-related inflammation and, as a result, a lowered secondary thrombocytosis.http://dx.doi.org/10.1155/2013/567984 |
| spellingShingle | Hans-Erik Johansson Arvo Haenni Björn Zethelius Platelet Counts and Liver Enzymes after Bariatric Surgery Journal of Obesity |
| title | Platelet Counts and Liver Enzymes after Bariatric Surgery |
| title_full | Platelet Counts and Liver Enzymes after Bariatric Surgery |
| title_fullStr | Platelet Counts and Liver Enzymes after Bariatric Surgery |
| title_full_unstemmed | Platelet Counts and Liver Enzymes after Bariatric Surgery |
| title_short | Platelet Counts and Liver Enzymes after Bariatric Surgery |
| title_sort | platelet counts and liver enzymes after bariatric surgery |
| url | http://dx.doi.org/10.1155/2013/567984 |
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