Calcineurin, Synaptic Plasticity, and Memory
A long-held hypothesis in neuroscience holds that learning and memory mechanisms involve lasting changes in synaptic weights. Multiple mechanisms for producing such changes exist, of which NMDA-receptor–dependent long-term potentiation (LTP) is the most widely studied. Curiously, the relatively simp...
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2001.259 |
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| author | Carl Weitlauf Danny Winder |
| author_facet | Carl Weitlauf Danny Winder |
| author_sort | Carl Weitlauf |
| collection | DOAJ |
| description | A long-held hypothesis in neuroscience holds that learning and memory mechanisms involve lasting changes in synaptic weights. Multiple mechanisms for producing such changes exist, of which NMDA-receptor–dependent long-term potentiation (LTP) is the most widely studied. Curiously, the relatively simple hypothesis that LTP plays a role in learning and memory has proven difficult to test. A current experimental strategy is to generate genetically altered mice with mutations in genes thought to be involved in LTP and assess the effects of these mutations both on LTP and animal behavior[1,2]. A difficulty associated with these approaches has been that they are not temporally or spatially refined. To alleviate this problem, Dr. Isabelle Mansuy and colleagues used an inducible and reversible transgene expression system in which transgene expression could be controlled on a week-to-week timescale to assess the effects of genetic reduction of the activity of a protein phosphatase known as calcineurin or PP2B in adult mouse forebrain[3,4]. |
| format | Article |
| id | doaj-art-b18cb6342ae94ba096a7562b1d09ac27 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-b18cb6342ae94ba096a7562b1d09ac272025-02-03T05:44:47ZengWileyThe Scientific World Journal1537-744X2001-01-01153053310.1100/tsw.2001.259Calcineurin, Synaptic Plasticity, and MemoryCarl Weitlauf0Danny Winder1Vanderbilt University School of Medicine, Department of Molecular Physiology and Biophysics, Nasville, TN 37235, USAVanderbilt University School of Medicine, Department of Molecular Physiology and Biophysics, Nasville, TN 37235, USAA long-held hypothesis in neuroscience holds that learning and memory mechanisms involve lasting changes in synaptic weights. Multiple mechanisms for producing such changes exist, of which NMDA-receptor–dependent long-term potentiation (LTP) is the most widely studied. Curiously, the relatively simple hypothesis that LTP plays a role in learning and memory has proven difficult to test. A current experimental strategy is to generate genetically altered mice with mutations in genes thought to be involved in LTP and assess the effects of these mutations both on LTP and animal behavior[1,2]. A difficulty associated with these approaches has been that they are not temporally or spatially refined. To alleviate this problem, Dr. Isabelle Mansuy and colleagues used an inducible and reversible transgene expression system in which transgene expression could be controlled on a week-to-week timescale to assess the effects of genetic reduction of the activity of a protein phosphatase known as calcineurin or PP2B in adult mouse forebrain[3,4].http://dx.doi.org/10.1100/tsw.2001.259 |
| spellingShingle | Carl Weitlauf Danny Winder Calcineurin, Synaptic Plasticity, and Memory The Scientific World Journal |
| title | Calcineurin, Synaptic Plasticity, and Memory |
| title_full | Calcineurin, Synaptic Plasticity, and Memory |
| title_fullStr | Calcineurin, Synaptic Plasticity, and Memory |
| title_full_unstemmed | Calcineurin, Synaptic Plasticity, and Memory |
| title_short | Calcineurin, Synaptic Plasticity, and Memory |
| title_sort | calcineurin synaptic plasticity and memory |
| url | http://dx.doi.org/10.1100/tsw.2001.259 |
| work_keys_str_mv | AT carlweitlauf calcineurinsynapticplasticityandmemory AT dannywinder calcineurinsynapticplasticityandmemory |