Pyogenic Brain Abscess: A Comprehensive Review of Epidemiology, Pathogenesis, Diagnosis, and Management
Background: Pyogenic brain abscess is a severe neurological infection associated with significant morbidity and mortality. Despite advances in diagnostic techniques, neurosurgical procedures, and antimicrobial therapy, managing pyogenic brain abscesses remains challenging. This article reviews the c...
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| Format: | Article |
| Language: | English |
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Shahid Beheshti University of Medical Sciences
2024-09-01
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| Series: | Novelty in Biomedicine |
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| Online Access: | https://journals.sbmu.ac.ir/nbm/article/view/45322 |
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| _version_ | 1832594092750536704 |
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| author | Peyman Eini Pooya Eini Latif Gachkar |
| author_facet | Peyman Eini Pooya Eini Latif Gachkar |
| author_sort | Peyman Eini |
| collection | DOAJ |
| description | Background: Pyogenic brain abscess is a severe neurological infection associated with significant morbidity and mortality. Despite advances in diagnostic techniques, neurosurgical procedures, and antimicrobial therapy, managing pyogenic brain abscesses remains challenging. This article reviews the current understanding of the epidemiology, pathogenesis, diagnosis, and treatment of pyogenic brain abscesses, highlighting the importance of a multidisciplinary approach to improve patient outcomes.
Materials and Methods: A comprehensive literature review was conducted using PubMed, Scopus, and Google Scholar databases. The search terms included "pyogenic brain abscess," "epidemiology," "pathogenesis," "diagnosis," "treatment," "antibiotic therapy," and "prognosis." Relevant articles published in English between 2010 and 2023 were selected, focusing on the most recent advances and evidence-based recommendations for managing pyogenic brain abscesses.
Results: Pyogenic brain abscess is a life-threatening condition that requires prompt diagnosis and treatment. A multidisciplinary approach involving neurosurgeons, infectious disease specialists, and radiologists is necessary to manage pyogenic brain abscesses successfully.
Conclusion: Early recognition, appropriate antibiotic therapy, and timely neurosurgical intervention are essential for improving patient outcomes and minimizing neurological sequelae. Antibiotic therapy and surgical approach should be tailored to the individual patient, considering factors such as the suspected pathogens, immune status, and the primary source of infection. Long-term follow-up is crucial, as recurrence and neurological sequelae are common among survivors. Continued research is needed to improve our understanding of this complex condition and develop more effective treatment strategies. |
| format | Article |
| id | doaj-art-b17fe54db0284d18bd59e8ff3179e0f1 |
| institution | Kabale University |
| issn | 2345-3907 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Novelty in Biomedicine |
| spelling | doaj-art-b17fe54db0284d18bd59e8ff3179e0f12025-01-20T05:02:54ZengShahid Beheshti University of Medical SciencesNovelty in Biomedicine2345-39072024-09-0112410.22037/nbm.v12i4.4532235213Pyogenic Brain Abscess: A Comprehensive Review of Epidemiology, Pathogenesis, Diagnosis, and ManagementPeyman Eini0Pooya Eini1Latif Gachkar21Infectious Disease Research Center, Hamadan University of Medical Sciences, Hamadan, Iran2Toxicological Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran3Department of Infectious Diseases, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranBackground: Pyogenic brain abscess is a severe neurological infection associated with significant morbidity and mortality. Despite advances in diagnostic techniques, neurosurgical procedures, and antimicrobial therapy, managing pyogenic brain abscesses remains challenging. This article reviews the current understanding of the epidemiology, pathogenesis, diagnosis, and treatment of pyogenic brain abscesses, highlighting the importance of a multidisciplinary approach to improve patient outcomes. Materials and Methods: A comprehensive literature review was conducted using PubMed, Scopus, and Google Scholar databases. The search terms included "pyogenic brain abscess," "epidemiology," "pathogenesis," "diagnosis," "treatment," "antibiotic therapy," and "prognosis." Relevant articles published in English between 2010 and 2023 were selected, focusing on the most recent advances and evidence-based recommendations for managing pyogenic brain abscesses. Results: Pyogenic brain abscess is a life-threatening condition that requires prompt diagnosis and treatment. A multidisciplinary approach involving neurosurgeons, infectious disease specialists, and radiologists is necessary to manage pyogenic brain abscesses successfully. Conclusion: Early recognition, appropriate antibiotic therapy, and timely neurosurgical intervention are essential for improving patient outcomes and minimizing neurological sequelae. Antibiotic therapy and surgical approach should be tailored to the individual patient, considering factors such as the suspected pathogens, immune status, and the primary source of infection. Long-term follow-up is crucial, as recurrence and neurological sequelae are common among survivors. Continued research is needed to improve our understanding of this complex condition and develop more effective treatment strategies.https://journals.sbmu.ac.ir/nbm/article/view/45322pyogenic brain abscessintracranial infectionneuroimagingantibiotic therapyneurosurgical intervention |
| spellingShingle | Peyman Eini Pooya Eini Latif Gachkar Pyogenic Brain Abscess: A Comprehensive Review of Epidemiology, Pathogenesis, Diagnosis, and Management Novelty in Biomedicine pyogenic brain abscess intracranial infection neuroimaging antibiotic therapy neurosurgical intervention |
| title | Pyogenic Brain Abscess: A Comprehensive Review of Epidemiology, Pathogenesis, Diagnosis, and Management |
| title_full | Pyogenic Brain Abscess: A Comprehensive Review of Epidemiology, Pathogenesis, Diagnosis, and Management |
| title_fullStr | Pyogenic Brain Abscess: A Comprehensive Review of Epidemiology, Pathogenesis, Diagnosis, and Management |
| title_full_unstemmed | Pyogenic Brain Abscess: A Comprehensive Review of Epidemiology, Pathogenesis, Diagnosis, and Management |
| title_short | Pyogenic Brain Abscess: A Comprehensive Review of Epidemiology, Pathogenesis, Diagnosis, and Management |
| title_sort | pyogenic brain abscess a comprehensive review of epidemiology pathogenesis diagnosis and management |
| topic | pyogenic brain abscess intracranial infection neuroimaging antibiotic therapy neurosurgical intervention |
| url | https://journals.sbmu.ac.ir/nbm/article/view/45322 |
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