Ultrastructure of Placenta of Gravidas with Gestational Diabetes Mellitus
Objectives. Gestational diabetes mellitus (GDM) leads to an abnormal placental environment which may cause some structural alterations of placenta and affect placental development and function. In this study, the ultrastructural appearances of term placentas from women with GDM and normal pregnancy...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2015/283124 |
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| author | Qian Meng Li Shao Xiucui Luo Yingping Mu Wen Xu Chao Gao Li Gao Jiayin Liu Yugui Cui |
| author_facet | Qian Meng Li Shao Xiucui Luo Yingping Mu Wen Xu Chao Gao Li Gao Jiayin Liu Yugui Cui |
| author_sort | Qian Meng |
| collection | DOAJ |
| description | Objectives. Gestational diabetes mellitus (GDM) leads to an abnormal placental environment which may cause some structural alterations of placenta and affect placental development and function. In this study, the ultrastructural appearances of term placentas from women with GDM and normal pregnancy were meticulously compared. Materials and Methods. The placenta tissues of term birth from 10 women with GDM and 10 women with normal pregnancy were applied with the signed informed consent. The morphology of fetomaternal interface of placenta was examined using light microscopy (LM) and transmission electron microscopy (TEM). Results. On LM, the following morphological changes in villous tissues were found in the GDM placentas when compared with the control placentas: edematous stroma, apparent increase in the number of syncytial knots, and perivillous fibrin deposition. On TEM, the distinct ultrastructural alterations indicating the degeneration of terminal villi were found in the GDM placentas as follows: thickening of the basal membrane (BM) of vasculosyncytial membrane (VSM) and the VSM itself, significantly fewer or even absent syncytiotrophoblastic microvilli, swollen or completely destroyed mitochondria and endoplasmic reticulum, and syncytiotrophoblasts with multiple vacuoles. Conclusion. Ultrastructural differences exist between GDM and control placentas. The differences of placenta ultrastructure are likely responsible for the impairment of placental barrier and function in GDM. |
| format | Article |
| id | doaj-art-b17e703e6c974f1498d1ea1c2768225c |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-b17e703e6c974f1498d1ea1c2768225c2025-02-03T01:09:35ZengWileyObstetrics and Gynecology International1687-95891687-95972015-01-01201510.1155/2015/283124283124Ultrastructure of Placenta of Gravidas with Gestational Diabetes MellitusQian Meng0Li Shao1Xiucui Luo2Yingping Mu3Wen Xu4Chao Gao5Li Gao6Jiayin Liu7Yugui Cui8Department of Obstetrics, Lianyungang Maternity and Child Health Care Hospital, Lianyungang 222000, ChinaThe State Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, ChinaDepartment of Obstetrics, Lianyungang Maternity and Child Health Care Hospital, Lianyungang 222000, ChinaDepartment of Obstetrics, Lianyungang Maternity and Child Health Care Hospital, Lianyungang 222000, ChinaDepartment of Obstetrics, Lianyungang Maternity and Child Health Care Hospital, Lianyungang 222000, ChinaThe State Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, ChinaThe State Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, ChinaThe State Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, ChinaThe State Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, ChinaObjectives. Gestational diabetes mellitus (GDM) leads to an abnormal placental environment which may cause some structural alterations of placenta and affect placental development and function. In this study, the ultrastructural appearances of term placentas from women with GDM and normal pregnancy were meticulously compared. Materials and Methods. The placenta tissues of term birth from 10 women with GDM and 10 women with normal pregnancy were applied with the signed informed consent. The morphology of fetomaternal interface of placenta was examined using light microscopy (LM) and transmission electron microscopy (TEM). Results. On LM, the following morphological changes in villous tissues were found in the GDM placentas when compared with the control placentas: edematous stroma, apparent increase in the number of syncytial knots, and perivillous fibrin deposition. On TEM, the distinct ultrastructural alterations indicating the degeneration of terminal villi were found in the GDM placentas as follows: thickening of the basal membrane (BM) of vasculosyncytial membrane (VSM) and the VSM itself, significantly fewer or even absent syncytiotrophoblastic microvilli, swollen or completely destroyed mitochondria and endoplasmic reticulum, and syncytiotrophoblasts with multiple vacuoles. Conclusion. Ultrastructural differences exist between GDM and control placentas. The differences of placenta ultrastructure are likely responsible for the impairment of placental barrier and function in GDM.http://dx.doi.org/10.1155/2015/283124 |
| spellingShingle | Qian Meng Li Shao Xiucui Luo Yingping Mu Wen Xu Chao Gao Li Gao Jiayin Liu Yugui Cui Ultrastructure of Placenta of Gravidas with Gestational Diabetes Mellitus Obstetrics and Gynecology International |
| title | Ultrastructure of Placenta of Gravidas with Gestational Diabetes Mellitus |
| title_full | Ultrastructure of Placenta of Gravidas with Gestational Diabetes Mellitus |
| title_fullStr | Ultrastructure of Placenta of Gravidas with Gestational Diabetes Mellitus |
| title_full_unstemmed | Ultrastructure of Placenta of Gravidas with Gestational Diabetes Mellitus |
| title_short | Ultrastructure of Placenta of Gravidas with Gestational Diabetes Mellitus |
| title_sort | ultrastructure of placenta of gravidas with gestational diabetes mellitus |
| url | http://dx.doi.org/10.1155/2015/283124 |
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