Prepartum Vaccination Against Neonatal Calf Diarrhea and Its Effect on Mammary Health and Milk Yield of Dairy Cows: A Retrospective Study Addressing Non-Specific Effects of Vaccination
Prepartum vaccinations against neonatal calf diarrhea pathogens are administered in late pregnancy to provide passive immunity to calves through protective colostral antibodies. Potential non-specific effects of the vaccine on maternal innate immune responses and disease susceptibility during the se...
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2025-01-01
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| Online Access: | https://www.mdpi.com/2076-2615/15/2/203 |
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| author | Caroline Kuhn Holm Zerbe Hans-Joachim Schuberth Anke Römer Debby Kraatz-van Egmond Claudia Wesenauer Martina Resch Alexander Stoll Yury Zablotski |
| author_facet | Caroline Kuhn Holm Zerbe Hans-Joachim Schuberth Anke Römer Debby Kraatz-van Egmond Claudia Wesenauer Martina Resch Alexander Stoll Yury Zablotski |
| author_sort | Caroline Kuhn |
| collection | DOAJ |
| description | Prepartum vaccinations against neonatal calf diarrhea pathogens are administered in late pregnancy to provide passive immunity to calves through protective colostral antibodies. Potential non-specific effects of the vaccine on maternal innate immune responses and disease susceptibility during the sensitive transition period have not been addressed so far. In this retrospective study, data from 73,378 dairy cows on 20 farms in Germany were analyzed, using linear mixed-effects regression, quantile regression, and decision-tree-algorithms, to investigate the effects of prepartum vaccination on mammary health and milk yield by comparing non-vaccinated and vaccinated transition periods. Herd management-related factors were found to be most influential for mammary health and milk yield. Vaccinated cows were not significantly more likely to develop mastitis and did not have significantly different somatic cell counts and milk yields compared to non-vaccinated cows. Healthy primiparous cows with and without vaccination had similar energy-corrected milk yields. The study concludes that prepartum vaccination against calf diarrhea has no significant effects on mammary health and milk yield. Further research is recommended to investigate potential non-specific vaccine effects on other organ systems, infectious diseases, and production metrics of the dairy cow. |
| format | Article |
| id | doaj-art-b17bbf5d5cd940e6b0cb3b4c6320df1f |
| institution | Kabale University |
| issn | 2076-2615 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Animals |
| spelling | doaj-art-b17bbf5d5cd940e6b0cb3b4c6320df1f2025-01-24T13:18:03ZengMDPI AGAnimals2076-26152025-01-0115220310.3390/ani15020203Prepartum Vaccination Against Neonatal Calf Diarrhea and Its Effect on Mammary Health and Milk Yield of Dairy Cows: A Retrospective Study Addressing Non-Specific Effects of VaccinationCaroline Kuhn0Holm Zerbe1Hans-Joachim Schuberth2Anke Römer3Debby Kraatz-van Egmond4Claudia Wesenauer5Martina Resch6Alexander Stoll7Yury Zablotski8Clinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-University, 80539 Munich, GermanyClinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-University, 80539 Munich, GermanyInstitute for Immunology, University of Veterinary Medicine, 30559 Hannover, GermanyMecklenburg-Vorpommern Research Centre for Agriculture and Fisheries, Institute of Livestock Farming, 18196 Dummerstorf, GermanyRinderAllianz GmbH, 17348 Woldegk, GermanyRinderAllianz GmbH, 17348 Woldegk, GermanyIntervet Deutschland GmbH, 85716 Unterschleissheim, GermanyIntervet Deutschland GmbH, 85716 Unterschleissheim, GermanyClinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-University, 80539 Munich, GermanyPrepartum vaccinations against neonatal calf diarrhea pathogens are administered in late pregnancy to provide passive immunity to calves through protective colostral antibodies. Potential non-specific effects of the vaccine on maternal innate immune responses and disease susceptibility during the sensitive transition period have not been addressed so far. In this retrospective study, data from 73,378 dairy cows on 20 farms in Germany were analyzed, using linear mixed-effects regression, quantile regression, and decision-tree-algorithms, to investigate the effects of prepartum vaccination on mammary health and milk yield by comparing non-vaccinated and vaccinated transition periods. Herd management-related factors were found to be most influential for mammary health and milk yield. Vaccinated cows were not significantly more likely to develop mastitis and did not have significantly different somatic cell counts and milk yields compared to non-vaccinated cows. Healthy primiparous cows with and without vaccination had similar energy-corrected milk yields. The study concludes that prepartum vaccination against calf diarrhea has no significant effects on mammary health and milk yield. Further research is recommended to investigate potential non-specific vaccine effects on other organ systems, infectious diseases, and production metrics of the dairy cow.https://www.mdpi.com/2076-2615/15/2/203transition cowvaccinationtrained immunitycattlebovine mastitisepidemiology |
| spellingShingle | Caroline Kuhn Holm Zerbe Hans-Joachim Schuberth Anke Römer Debby Kraatz-van Egmond Claudia Wesenauer Martina Resch Alexander Stoll Yury Zablotski Prepartum Vaccination Against Neonatal Calf Diarrhea and Its Effect on Mammary Health and Milk Yield of Dairy Cows: A Retrospective Study Addressing Non-Specific Effects of Vaccination Animals transition cow vaccination trained immunity cattle bovine mastitis epidemiology |
| title | Prepartum Vaccination Against Neonatal Calf Diarrhea and Its Effect on Mammary Health and Milk Yield of Dairy Cows: A Retrospective Study Addressing Non-Specific Effects of Vaccination |
| title_full | Prepartum Vaccination Against Neonatal Calf Diarrhea and Its Effect on Mammary Health and Milk Yield of Dairy Cows: A Retrospective Study Addressing Non-Specific Effects of Vaccination |
| title_fullStr | Prepartum Vaccination Against Neonatal Calf Diarrhea and Its Effect on Mammary Health and Milk Yield of Dairy Cows: A Retrospective Study Addressing Non-Specific Effects of Vaccination |
| title_full_unstemmed | Prepartum Vaccination Against Neonatal Calf Diarrhea and Its Effect on Mammary Health and Milk Yield of Dairy Cows: A Retrospective Study Addressing Non-Specific Effects of Vaccination |
| title_short | Prepartum Vaccination Against Neonatal Calf Diarrhea and Its Effect on Mammary Health and Milk Yield of Dairy Cows: A Retrospective Study Addressing Non-Specific Effects of Vaccination |
| title_sort | prepartum vaccination against neonatal calf diarrhea and its effect on mammary health and milk yield of dairy cows a retrospective study addressing non specific effects of vaccination |
| topic | transition cow vaccination trained immunity cattle bovine mastitis epidemiology |
| url | https://www.mdpi.com/2076-2615/15/2/203 |
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