Pulsed Low-Intensity Focused Ultrasound (LIFU) Activation of Ovarian Follicles
<italic>Objective:</italic> A biological system's internal morphological structure or function can be changed as a result of the mechanical effect of focused ultrasound. Pulsed low-intensity focused ultrasound (LIFU) has mechanical effects that might induce follicle developmen...
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IEEE
2024-01-01
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| Series: | IEEE Open Journal of Engineering in Medicine and Biology |
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| Online Access: | https://ieeexplore.ieee.org/document/10508955/ |
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| author | Yan Xiao Lixia Yang Yicong Wang Yu Wang Yuning Chen Wenhan Lu Zhenle Pei Ruonan Zhang Yao Ye Xiaowei Ji Suying Liu Xi Dong Yonghua Xu Yi Feng |
| author_facet | Yan Xiao Lixia Yang Yicong Wang Yu Wang Yuning Chen Wenhan Lu Zhenle Pei Ruonan Zhang Yao Ye Xiaowei Ji Suying Liu Xi Dong Yonghua Xu Yi Feng |
| author_sort | Yan Xiao |
| collection | DOAJ |
| description | <italic>Objective:</italic> A biological system's internal morphological structure or function can be changed as a result of the mechanical effect of focused ultrasound. Pulsed low-intensity focused ultrasound (LIFU) has mechanical effects that might induce follicle development with less damage to ovarian tissue. The potential development of LIFU as a non-invasive method for the treatment of female infertility is being considered, and this study sought to explore and confirm that LIFU can activate ovarian follicles. <italic>Results:</italic> We found a 50% increase in ovarian weight and in the number of mature follicles on the ultrasound-stimulated side with pulsed LIFU and intraperitoneal injection of 10 IU PMSG in 10-day-old rats. After ultrasound stimulation, the PCOS-like rats had a decrease in androgen levels, restoration of regular estrous cycle and increase in the number of mature follicles and corpora lutea, and the ratio of M1 and M2 type macrophages was altered in antral follicles of PCOS-like rats, consequently promoting further development and maturation of antral follicles. <italic>Conclusion:</italic> LIFU treatment could trigger actin changes in ovarian cells, which might disrupt the Hippo signal pathway to promote follicle formation, and the mechanical impact on the ovaries of PCOS-like rats improved antral follicle development. |
| format | Article |
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| institution | Kabale University |
| issn | 2644-1276 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | IEEE |
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| series | IEEE Open Journal of Engineering in Medicine and Biology |
| spelling | doaj-art-b170339aad2e41dc99d7e931c8538e8e2025-01-30T00:03:41ZengIEEEIEEE Open Journal of Engineering in Medicine and Biology2644-12762024-01-01531632910.1109/OJEMB.2024.339193910508955Pulsed Low-Intensity Focused Ultrasound (LIFU) Activation of Ovarian FolliclesYan Xiao0https://orcid.org/0009-0009-2281-4375Lixia Yang1https://orcid.org/0009-0004-5418-0913Yicong Wang2https://orcid.org/0000-0001-9102-4363Yu Wang3https://orcid.org/0000-0003-1077-9305Yuning Chen4https://orcid.org/0009-0007-4010-2756Wenhan Lu5https://orcid.org/0000-0003-3890-5553Zhenle Pei6https://orcid.org/0000-0002-8921-2872Ruonan Zhang7https://orcid.org/0000-0003-4882-2284Yao Ye8https://orcid.org/0009-0004-5417-1750Xiaowei Ji9https://orcid.org/0000-0002-7569-2799Suying Liu10https://orcid.org/0000-0002-3148-2247Xi Dong11https://orcid.org/0000-0002-3903-0747Yonghua Xu12https://orcid.org/0000-0002-3632-8900Yi Feng13https://orcid.org/0000-0002-7156-6023Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Brain Science Collaborative Innovation Center, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, ChinaDepartment of Imaging and Interventional Radiology, Zhongshan-Xuhui Hospital of Fudan University/Xuhui Center Hospital, Shanghai, ChinaDepartment of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Brain Science Collaborative Innovation Center, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, ChinaDepartment of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Brain Science Collaborative Innovation Center, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, ChinaDepartment of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Brain Science Collaborative Innovation Center, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, ChinaDepartment of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Brain Science Collaborative Innovation Center, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, ChinaDepartment of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Brain Science Collaborative Innovation Center, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, ChinaReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, ChinaReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, ChinaReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, ChinaReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Imaging and Interventional Radiology, Zhongshan-Xuhui Hospital of Fudan University/Xuhui Center Hospital, Shanghai, ChinaDepartment of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Brain Science Collaborative Innovation Center, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China<italic>Objective:</italic> A biological system's internal morphological structure or function can be changed as a result of the mechanical effect of focused ultrasound. Pulsed low-intensity focused ultrasound (LIFU) has mechanical effects that might induce follicle development with less damage to ovarian tissue. The potential development of LIFU as a non-invasive method for the treatment of female infertility is being considered, and this study sought to explore and confirm that LIFU can activate ovarian follicles. <italic>Results:</italic> We found a 50% increase in ovarian weight and in the number of mature follicles on the ultrasound-stimulated side with pulsed LIFU and intraperitoneal injection of 10 IU PMSG in 10-day-old rats. After ultrasound stimulation, the PCOS-like rats had a decrease in androgen levels, restoration of regular estrous cycle and increase in the number of mature follicles and corpora lutea, and the ratio of M1 and M2 type macrophages was altered in antral follicles of PCOS-like rats, consequently promoting further development and maturation of antral follicles. <italic>Conclusion:</italic> LIFU treatment could trigger actin changes in ovarian cells, which might disrupt the Hippo signal pathway to promote follicle formation, and the mechanical impact on the ovaries of PCOS-like rats improved antral follicle development.https://ieeexplore.ieee.org/document/10508955/Focused ultrasoundfollicle developmentpolycystic ovary syndrome |
| spellingShingle | Yan Xiao Lixia Yang Yicong Wang Yu Wang Yuning Chen Wenhan Lu Zhenle Pei Ruonan Zhang Yao Ye Xiaowei Ji Suying Liu Xi Dong Yonghua Xu Yi Feng Pulsed Low-Intensity Focused Ultrasound (LIFU) Activation of Ovarian Follicles IEEE Open Journal of Engineering in Medicine and Biology Focused ultrasound follicle development polycystic ovary syndrome |
| title | Pulsed Low-Intensity Focused Ultrasound (LIFU) Activation of Ovarian Follicles |
| title_full | Pulsed Low-Intensity Focused Ultrasound (LIFU) Activation of Ovarian Follicles |
| title_fullStr | Pulsed Low-Intensity Focused Ultrasound (LIFU) Activation of Ovarian Follicles |
| title_full_unstemmed | Pulsed Low-Intensity Focused Ultrasound (LIFU) Activation of Ovarian Follicles |
| title_short | Pulsed Low-Intensity Focused Ultrasound (LIFU) Activation of Ovarian Follicles |
| title_sort | pulsed low intensity focused ultrasound lifu activation of ovarian follicles |
| topic | Focused ultrasound follicle development polycystic ovary syndrome |
| url | https://ieeexplore.ieee.org/document/10508955/ |
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