Phytochemical composition, phytotoxicity, and ADME modeling of Artemisia absinthium L.: implications for food safety and pharmaceutical applications
Artemisia absinthium, an aromatic herb distinguished by its characteristic bitter flavour, has been used in a variety of culinary applications. This study investigates its metabolites through phytochemical methods. The primary minerals in Artemisia absinthium stems are potassium (41%) and calcium (3...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | CyTA - Journal of Food |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19476337.2025.2451980 |
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| author | Asmae Hbika Ayoub Farihi Mohammed Benali Fatima-Zahrae Ed-darraz Abdelhamid Bouyanzer Mohammed F. Hawwal Ramzi A. Mothana Elkhadir Gharibi |
| author_facet | Asmae Hbika Ayoub Farihi Mohammed Benali Fatima-Zahrae Ed-darraz Abdelhamid Bouyanzer Mohammed F. Hawwal Ramzi A. Mothana Elkhadir Gharibi |
| author_sort | Asmae Hbika |
| collection | DOAJ |
| description | Artemisia absinthium, an aromatic herb distinguished by its characteristic bitter flavour, has been used in a variety of culinary applications. This study investigates its metabolites through phytochemical methods. The primary minerals in Artemisia absinthium stems are potassium (41%) and calcium (38.3%), forming most of its mineral content. The ethanolic extract exhibited the highest phenolic compound content, with 37.6 ± 0.09 mg GAE/g DE. The primary volatile compound identified was β-thujone, comprising over 26.6% of the volatile content. Palmitic acid is the predominant fatty acid in the hexanic extract (18.7%), while linoleic acid is the main fatty acid in the ethyl acetate extract (42.4%). Twenty phenolic compounds were identified, with 8-methoxyflavone, (+)-catechin hydrate, and chlorogenic acid as major compounds in dichloromethane, ethyl acetate, and ethanol extracts, respectively. ADME modeling indicating that 8-methoxyflavone, a major component in the dichloromethane extract, is a promising candidate for drug development targeting the central nervous system. |
| format | Article |
| id | doaj-art-b147eeb863af4955818e4d4bb39d69e1 |
| institution | Kabale University |
| issn | 1947-6337 1947-6345 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | CyTA - Journal of Food |
| spelling | doaj-art-b147eeb863af4955818e4d4bb39d69e12025-01-21T16:34:58ZengTaylor & Francis GroupCyTA - Journal of Food1947-63371947-63452025-12-0123110.1080/19476337.2025.2451980Phytochemical composition, phytotoxicity, and ADME modeling of Artemisia absinthium L.: implications for food safety and pharmaceutical applicationsAsmae Hbika0Ayoub Farihi1Mohammed Benali2Fatima-Zahrae Ed-darraz3Abdelhamid Bouyanzer4Mohammed F. Hawwal5Ramzi A. Mothana6Elkhadir Gharibi7Laboratory of Applied and Environmental Chemistry, Faculty of Sciences, Mohammed First University, Oujda, MoroccoLaboratory of Bioresources, Biotechnology, Ethnopharmacology, and Health, Faculty of Sciences, Mohammed First University, Oujda, MoroccoESCOM, TIMR (Integrated Transformations of Renewable Matter), Centre de Recherche Royallieu-CS, Université de Technologie de Compiègne, Cedex, FranceLaboratory of Applied and Environmental Chemistry, Faculty of Sciences, Mohammed First University, Oujda, MoroccoLaboratory of Applied and Environmental Chemistry, Faculty of Sciences, Mohammed First University, Oujda, MoroccoDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaLaboratory of Applied and Environmental Chemistry, Faculty of Sciences, Mohammed First University, Oujda, MoroccoArtemisia absinthium, an aromatic herb distinguished by its characteristic bitter flavour, has been used in a variety of culinary applications. This study investigates its metabolites through phytochemical methods. The primary minerals in Artemisia absinthium stems are potassium (41%) and calcium (38.3%), forming most of its mineral content. The ethanolic extract exhibited the highest phenolic compound content, with 37.6 ± 0.09 mg GAE/g DE. The primary volatile compound identified was β-thujone, comprising over 26.6% of the volatile content. Palmitic acid is the predominant fatty acid in the hexanic extract (18.7%), while linoleic acid is the main fatty acid in the ethyl acetate extract (42.4%). Twenty phenolic compounds were identified, with 8-methoxyflavone, (+)-catechin hydrate, and chlorogenic acid as major compounds in dichloromethane, ethyl acetate, and ethanol extracts, respectively. ADME modeling indicating that 8-methoxyflavone, a major component in the dichloromethane extract, is a promising candidate for drug development targeting the central nervous system.https://www.tandfonline.com/doi/10.1080/19476337.2025.2451980Artemisia absinthiumphytochemical compositionvolatiles compoundsfatty acidsphenolic compoundsphytotoxicity |
| spellingShingle | Asmae Hbika Ayoub Farihi Mohammed Benali Fatima-Zahrae Ed-darraz Abdelhamid Bouyanzer Mohammed F. Hawwal Ramzi A. Mothana Elkhadir Gharibi Phytochemical composition, phytotoxicity, and ADME modeling of Artemisia absinthium L.: implications for food safety and pharmaceutical applications CyTA - Journal of Food Artemisia absinthium phytochemical composition volatiles compounds fatty acids phenolic compounds phytotoxicity |
| title | Phytochemical composition, phytotoxicity, and ADME modeling of Artemisia absinthium L.: implications for food safety and pharmaceutical applications |
| title_full | Phytochemical composition, phytotoxicity, and ADME modeling of Artemisia absinthium L.: implications for food safety and pharmaceutical applications |
| title_fullStr | Phytochemical composition, phytotoxicity, and ADME modeling of Artemisia absinthium L.: implications for food safety and pharmaceutical applications |
| title_full_unstemmed | Phytochemical composition, phytotoxicity, and ADME modeling of Artemisia absinthium L.: implications for food safety and pharmaceutical applications |
| title_short | Phytochemical composition, phytotoxicity, and ADME modeling of Artemisia absinthium L.: implications for food safety and pharmaceutical applications |
| title_sort | phytochemical composition phytotoxicity and adme modeling of artemisia absinthium l implications for food safety and pharmaceutical applications |
| topic | Artemisia absinthium phytochemical composition volatiles compounds fatty acids phenolic compounds phytotoxicity |
| url | https://www.tandfonline.com/doi/10.1080/19476337.2025.2451980 |
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