Long-term survival with pemetrexed-based chemotherapy in a patient with metastatic lung adenocarcinoma of unclear primary origin harboring MTHFR C677T(T/T) mutation: a case report
This case report presents a patient with metastatic adenocarcinoma of unclear primary focus at initial presentation and revealed lung adenocarcinoma in subsequent follow-up. The patient has been surviving for more than 10 years after pemetrexed-based treatment and local radiotherapy. Sequential gene...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1435357/full |
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| author | Yuan Yu Yuan Yu Yuan Yu Nan-Jing Li Nan-Jing Li Nan-Jing Li Nan-Jing Li Jin Wang Jin Wang Jin Wang Jin Wang |
| author_facet | Yuan Yu Yuan Yu Yuan Yu Nan-Jing Li Nan-Jing Li Nan-Jing Li Nan-Jing Li Jin Wang Jin Wang Jin Wang Jin Wang |
| author_sort | Yuan Yu |
| collection | DOAJ |
| description | This case report presents a patient with metastatic adenocarcinoma of unclear primary focus at initial presentation and revealed lung adenocarcinoma in subsequent follow-up. The patient has been surviving for more than 10 years after pemetrexed-based treatment and local radiotherapy. Sequential gene tests showed kirsten rat sarcoma viral oncogene homolog (KRAS) G13D mutation and epidermal growth factor receptor (EGFR) 19ins. To further investigate the correlation between pemetrexed efficacy and genetic polymorphisms, genotyping tests on folate-metabolism-related genes [methylenetetrahydrofolate reductase (MTHFR) (C677T) and MTHFR (A1298C)] were performed, revealing that the patient exhibited the T/T genotype for MTHFR (C677T) and the A/A genotype for MTHFR (A1298C). The clinical data and gene analysis were discussed with literature review to explain the underlying explanation for the long survival. |
| format | Article |
| id | doaj-art-b14769ab1bd84cb98d347579243fd5a5 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-b14769ab1bd84cb98d347579243fd5a52025-01-21T05:43:34ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14353571435357Long-term survival with pemetrexed-based chemotherapy in a patient with metastatic lung adenocarcinoma of unclear primary origin harboring MTHFR C677T(T/T) mutation: a case reportYuan Yu0Yuan Yu1Yuan Yu2Nan-Jing Li3Nan-Jing Li4Nan-Jing Li5Nan-Jing Li6Jin Wang7Jin Wang8Jin Wang9Jin Wang10Division of Thoracic Tumor Multimodality Treatment and Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaWest China Medical School, Sichuan University, Chengdu, Sichuan, ChinaWest China Biomedical Big Data Center, Sichuan University, Chengdu, Sichuan, ChinaDivision of Thoracic Tumor Multimodality Treatment and Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaWest China Medical School, Sichuan University, Chengdu, Sichuan, ChinaWest China Biomedical Big Data Center, Sichuan University, Chengdu, Sichuan, ChinaDivision of Radiotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaDivision of Thoracic Tumor Multimodality Treatment and Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaWest China Medical School, Sichuan University, Chengdu, Sichuan, ChinaWest China Biomedical Big Data Center, Sichuan University, Chengdu, Sichuan, ChinaDivision of Radiotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaThis case report presents a patient with metastatic adenocarcinoma of unclear primary focus at initial presentation and revealed lung adenocarcinoma in subsequent follow-up. The patient has been surviving for more than 10 years after pemetrexed-based treatment and local radiotherapy. Sequential gene tests showed kirsten rat sarcoma viral oncogene homolog (KRAS) G13D mutation and epidermal growth factor receptor (EGFR) 19ins. To further investigate the correlation between pemetrexed efficacy and genetic polymorphisms, genotyping tests on folate-metabolism-related genes [methylenetetrahydrofolate reductase (MTHFR) (C677T) and MTHFR (A1298C)] were performed, revealing that the patient exhibited the T/T genotype for MTHFR (C677T) and the A/A genotype for MTHFR (A1298C). The clinical data and gene analysis were discussed with literature review to explain the underlying explanation for the long survival.https://www.frontiersin.org/articles/10.3389/fonc.2024.1435357/fullpemetrexednext-generation sequencingadenocarcinomalung cancerMTHFRpolymorphism |
| spellingShingle | Yuan Yu Yuan Yu Yuan Yu Nan-Jing Li Nan-Jing Li Nan-Jing Li Nan-Jing Li Jin Wang Jin Wang Jin Wang Jin Wang Long-term survival with pemetrexed-based chemotherapy in a patient with metastatic lung adenocarcinoma of unclear primary origin harboring MTHFR C677T(T/T) mutation: a case report Frontiers in Oncology pemetrexed next-generation sequencing adenocarcinoma lung cancer MTHFR polymorphism |
| title | Long-term survival with pemetrexed-based chemotherapy in a patient with metastatic lung adenocarcinoma of unclear primary origin harboring MTHFR C677T(T/T) mutation: a case report |
| title_full | Long-term survival with pemetrexed-based chemotherapy in a patient with metastatic lung adenocarcinoma of unclear primary origin harboring MTHFR C677T(T/T) mutation: a case report |
| title_fullStr | Long-term survival with pemetrexed-based chemotherapy in a patient with metastatic lung adenocarcinoma of unclear primary origin harboring MTHFR C677T(T/T) mutation: a case report |
| title_full_unstemmed | Long-term survival with pemetrexed-based chemotherapy in a patient with metastatic lung adenocarcinoma of unclear primary origin harboring MTHFR C677T(T/T) mutation: a case report |
| title_short | Long-term survival with pemetrexed-based chemotherapy in a patient with metastatic lung adenocarcinoma of unclear primary origin harboring MTHFR C677T(T/T) mutation: a case report |
| title_sort | long term survival with pemetrexed based chemotherapy in a patient with metastatic lung adenocarcinoma of unclear primary origin harboring mthfr c677t t t mutation a case report |
| topic | pemetrexed next-generation sequencing adenocarcinoma lung cancer MTHFR polymorphism |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1435357/full |
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