Diagnosing Celiac Disease: Towards Wide-Scale Screening and Serology-Based Criteria?
Celiac disease is one of the most common food-related chronic disorders in children. Unfortunately, this multifaceted disease is challenging to recognize and remains markedly underdiagnosed. Screening of either known at-risk groups or even the whole population could increase the suboptimal diagnosti...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/2916024 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564287990661120 |
|---|---|
| author | Alina Popp Laura Kivelä Valma Fuchs Kalle Kurppa |
| author_facet | Alina Popp Laura Kivelä Valma Fuchs Kalle Kurppa |
| author_sort | Alina Popp |
| collection | DOAJ |
| description | Celiac disease is one of the most common food-related chronic disorders in children. Unfortunately, this multifaceted disease is challenging to recognize and remains markedly underdiagnosed. Screening of either known at-risk groups or even the whole population could increase the suboptimal diagnostic yield substantially. Many recent guidelines recommend screening of at least selected risk groups, but more wide-scale screening remains controversial. The increasing prevalence of celiac disease and the development of autoantibody assays have also led to a gradual shift in the diagnostics towards less invasive serology-based criteria in a subgroup of symptomatic children. The main open questions concern whether these criteria are applicable to all countries and clinical settings, as well as to adult patients. On the other hand, widening screening and the mistaken practice of initiating a gluten-free diet before the appropriate exclusion of celiac disease increase the number of borderline seropositive cases, which may also challenge the classical histopathological diagnostics. Sophisticated diagnostic methods and a deeper understanding of the natural history of early developing celiac disease may prove useful in these circumstances. |
| format | Article |
| id | doaj-art-b12e929df84c4df98a0b84ee87754b22 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-b12e929df84c4df98a0b84ee87754b222025-02-03T01:11:29ZengWileyGastroenterology Research and Practice1687-61211687-630X2019-01-01201910.1155/2019/29160242916024Diagnosing Celiac Disease: Towards Wide-Scale Screening and Serology-Based Criteria?Alina Popp0Laura Kivelä1Valma Fuchs2Kalle Kurppa3Center for Child Health Research, Tampere University and Department of Paediatrics, Tampere University Hospital, Tampere, FinlandCenter for Child Health Research, Tampere University and Department of Paediatrics, Tampere University Hospital, Tampere, FinlandCeliac Disease Research Center, Tampere University, Tampere, FinlandCenter for Child Health Research, Tampere University and Department of Paediatrics, Tampere University Hospital, Tampere, FinlandCeliac disease is one of the most common food-related chronic disorders in children. Unfortunately, this multifaceted disease is challenging to recognize and remains markedly underdiagnosed. Screening of either known at-risk groups or even the whole population could increase the suboptimal diagnostic yield substantially. Many recent guidelines recommend screening of at least selected risk groups, but more wide-scale screening remains controversial. The increasing prevalence of celiac disease and the development of autoantibody assays have also led to a gradual shift in the diagnostics towards less invasive serology-based criteria in a subgroup of symptomatic children. The main open questions concern whether these criteria are applicable to all countries and clinical settings, as well as to adult patients. On the other hand, widening screening and the mistaken practice of initiating a gluten-free diet before the appropriate exclusion of celiac disease increase the number of borderline seropositive cases, which may also challenge the classical histopathological diagnostics. Sophisticated diagnostic methods and a deeper understanding of the natural history of early developing celiac disease may prove useful in these circumstances.http://dx.doi.org/10.1155/2019/2916024 |
| spellingShingle | Alina Popp Laura Kivelä Valma Fuchs Kalle Kurppa Diagnosing Celiac Disease: Towards Wide-Scale Screening and Serology-Based Criteria? Gastroenterology Research and Practice |
| title | Diagnosing Celiac Disease: Towards Wide-Scale Screening and Serology-Based Criteria? |
| title_full | Diagnosing Celiac Disease: Towards Wide-Scale Screening and Serology-Based Criteria? |
| title_fullStr | Diagnosing Celiac Disease: Towards Wide-Scale Screening and Serology-Based Criteria? |
| title_full_unstemmed | Diagnosing Celiac Disease: Towards Wide-Scale Screening and Serology-Based Criteria? |
| title_short | Diagnosing Celiac Disease: Towards Wide-Scale Screening and Serology-Based Criteria? |
| title_sort | diagnosing celiac disease towards wide scale screening and serology based criteria |
| url | http://dx.doi.org/10.1155/2019/2916024 |
| work_keys_str_mv | AT alinapopp diagnosingceliacdiseasetowardswidescalescreeningandserologybasedcriteria AT laurakivela diagnosingceliacdiseasetowardswidescalescreeningandserologybasedcriteria AT valmafuchs diagnosingceliacdiseasetowardswidescalescreeningandserologybasedcriteria AT kallekurppa diagnosingceliacdiseasetowardswidescalescreeningandserologybasedcriteria |