ANTIOXIDANT POTENTIAL OF TEMULAWAK (CURCUMA XANTHORRHIZA) EXTRACT GEL AS A CANDIDATE FOR WOUND HEALING
Background: The complete treatment of chronic wounds remains a significant unmet medical need. To expedite the healing of chronic wounds, numerous studies have begun to utilize gels, including hydrogels or sol-gels, which incorporate a combination of antioxidant properties. Curcuma xanthorrhiza is k...
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| Format: | Article |
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Universitas Airlangga
2024-03-01
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| Series: | Journal of Vocational Health Studies |
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| Online Access: | https://e-journal.unair.ac.id/JVHS/article/view/42376 |
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| author | Reghita Claudia Malau Sri Wahyuni Nasution Ali Napiah Nasution Wahyu Widowati Faradhina Salfa Nindya Hanna Sari Widya Kusuma |
| author_facet | Reghita Claudia Malau Sri Wahyuni Nasution Ali Napiah Nasution Wahyu Widowati Faradhina Salfa Nindya Hanna Sari Widya Kusuma |
| author_sort | Reghita Claudia Malau |
| collection | DOAJ |
| description | Background: The complete treatment of chronic wounds remains a significant unmet medical need. To expedite the healing of chronic wounds, numerous studies have begun to utilize gels, including hydrogels or sol-gels, which incorporate a combination of antioxidant properties. Curcuma xanthorrhiza is known to contain polyphenolic compounds, which include flavonoids acting as an antioxidant. Purpose: Examine the potential of C. xanthorrhiza extract (CXE) gel as a candidate for wound-healing by measuring its antioxidant activity. Method: Three CXE gel formulas were prepared from different concentrations of CMC-Na (3, 4, and 5%). Each formula consisted of 5% CXE, 15% propylene Glycol, 10% Glycerin, 0.25% Methylparaben, and distilled water. The quality of the CXE gel was tested through homogeneity, spreadability, pH, and viscosity tests. The antioxidant activity was measured by 2,2-Diphenyl-1-picrylhydrazil (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS)-reducing activity assay in a gel formula that was close the standards. The measurement results were then used in the calculation of antioxidant activity to determine the IC50 value. Result: Formulas 1, 2, and 3 meet the requirements by yielding a homogeneous gel with a spreadability of 5.37 – 5.93 cm, a pH level of 5.87 – 6.10, and a viscosity of 8.800 – 9296.67 cps. The highest DPPH and ABTS percentages were 34.04% and 5.28%, respectively. The IC50 values of CXE gel in DPPH and ABTS were 1973.38 μg/mL and 700.65 μg/mL, respectively. Conclusion: The CXE 1, 2, and 3 gel formula meets the requirements and has the potential to be used as a wound healing therapy through its antioxidant properties. |
| format | Article |
| id | doaj-art-b120b992c90e4e378fd0e73fd817194b |
| institution | Kabale University |
| issn | 2580-7161 2580-717X |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Universitas Airlangga |
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| series | Journal of Vocational Health Studies |
| spelling | doaj-art-b120b992c90e4e378fd0e73fd817194b2025-02-03T06:16:47ZengUniversitas AirlanggaJournal of Vocational Health Studies2580-71612580-717X2024-03-017316617410.20473/jvhs.V7.I3.2024.166-17440457ANTIOXIDANT POTENTIAL OF TEMULAWAK (CURCUMA XANTHORRHIZA) EXTRACT GEL AS A CANDIDATE FOR WOUND HEALINGReghita Claudia Malau0https://orcid.org/0009-0008-5267-138XSri Wahyuni Nasution1https://orcid.org/0000-0001-7553-6609Ali Napiah Nasution2https://orcid.org/0000-0002-1533-5749Wahyu Widowati3https://orcid.org/0000-0002-5401-7794Faradhina Salfa Nindya4https://orcid.org/0009-0000-9547-6711Hanna Sari Widya Kusuma5https://orcid.org/0000-0002-7422-0036Department of Tropical Medicine, Faculty of Medicine, Prima Indonesia University, Medan, IndonesiaDepartment of Tropical Medicine, Faculty of Medicine, Prima Indonesia University, Medan, IndonesiaDepartment of Tropical Medicine, Faculty of Medicine, Prima Indonesia University, Medan, IndonesiaDepartment of Pharmacology Faculty of Medicine, Maranatha Christian University, Bandung, IndonesiaBiomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung, IndonesiaBiomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung, IndonesiaBackground: The complete treatment of chronic wounds remains a significant unmet medical need. To expedite the healing of chronic wounds, numerous studies have begun to utilize gels, including hydrogels or sol-gels, which incorporate a combination of antioxidant properties. Curcuma xanthorrhiza is known to contain polyphenolic compounds, which include flavonoids acting as an antioxidant. Purpose: Examine the potential of C. xanthorrhiza extract (CXE) gel as a candidate for wound-healing by measuring its antioxidant activity. Method: Three CXE gel formulas were prepared from different concentrations of CMC-Na (3, 4, and 5%). Each formula consisted of 5% CXE, 15% propylene Glycol, 10% Glycerin, 0.25% Methylparaben, and distilled water. The quality of the CXE gel was tested through homogeneity, spreadability, pH, and viscosity tests. The antioxidant activity was measured by 2,2-Diphenyl-1-picrylhydrazil (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS)-reducing activity assay in a gel formula that was close the standards. The measurement results were then used in the calculation of antioxidant activity to determine the IC50 value. Result: Formulas 1, 2, and 3 meet the requirements by yielding a homogeneous gel with a spreadability of 5.37 – 5.93 cm, a pH level of 5.87 – 6.10, and a viscosity of 8.800 – 9296.67 cps. The highest DPPH and ABTS percentages were 34.04% and 5.28%, respectively. The IC50 values of CXE gel in DPPH and ABTS were 1973.38 μg/mL and 700.65 μg/mL, respectively. Conclusion: The CXE 1, 2, and 3 gel formula meets the requirements and has the potential to be used as a wound healing therapy through its antioxidant properties.https://e-journal.unair.ac.id/JVHS/article/view/42376antioxidantcurcuma xanthorrhizagelwound healing |
| spellingShingle | Reghita Claudia Malau Sri Wahyuni Nasution Ali Napiah Nasution Wahyu Widowati Faradhina Salfa Nindya Hanna Sari Widya Kusuma ANTIOXIDANT POTENTIAL OF TEMULAWAK (CURCUMA XANTHORRHIZA) EXTRACT GEL AS A CANDIDATE FOR WOUND HEALING Journal of Vocational Health Studies antioxidant curcuma xanthorrhiza gel wound healing |
| title | ANTIOXIDANT POTENTIAL OF TEMULAWAK (CURCUMA XANTHORRHIZA) EXTRACT GEL AS A CANDIDATE FOR WOUND HEALING |
| title_full | ANTIOXIDANT POTENTIAL OF TEMULAWAK (CURCUMA XANTHORRHIZA) EXTRACT GEL AS A CANDIDATE FOR WOUND HEALING |
| title_fullStr | ANTIOXIDANT POTENTIAL OF TEMULAWAK (CURCUMA XANTHORRHIZA) EXTRACT GEL AS A CANDIDATE FOR WOUND HEALING |
| title_full_unstemmed | ANTIOXIDANT POTENTIAL OF TEMULAWAK (CURCUMA XANTHORRHIZA) EXTRACT GEL AS A CANDIDATE FOR WOUND HEALING |
| title_short | ANTIOXIDANT POTENTIAL OF TEMULAWAK (CURCUMA XANTHORRHIZA) EXTRACT GEL AS A CANDIDATE FOR WOUND HEALING |
| title_sort | antioxidant potential of temulawak curcuma xanthorrhiza extract gel as a candidate for wound healing |
| topic | antioxidant curcuma xanthorrhiza gel wound healing |
| url | https://e-journal.unair.ac.id/JVHS/article/view/42376 |
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