Decoding the mechanisms behind second primary cancers
Abstract Second Primary Cancers (SPCs) are defined as cancers that develop either simultaneously or metachronously in the same individual who has been diagnosed with and survived one primary cancer. SPCs exhibit a high incidence rate and represent the primary cause of mortality among survivors of fi...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06151-9 |
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| author | Meiyuan Zeng Anqi Lin Aimin Jiang Zhengang Qiu Hongman Zhang Shifu Chen Mingyan Xu Zaoqu Liu Quan Cheng Jian Zhang Peng Luo |
| author_facet | Meiyuan Zeng Anqi Lin Aimin Jiang Zhengang Qiu Hongman Zhang Shifu Chen Mingyan Xu Zaoqu Liu Quan Cheng Jian Zhang Peng Luo |
| author_sort | Meiyuan Zeng |
| collection | DOAJ |
| description | Abstract Second Primary Cancers (SPCs) are defined as cancers that develop either simultaneously or metachronously in the same individual who has been diagnosed with and survived one primary cancer. SPCs exhibit a high incidence rate and represent the primary cause of mortality among survivors of first primary cancers. There is growing concern about the dangers of SPCs. This review summarizes recent studies on the mechanisms of SPCs, including the roles of genomic changes after first primary cancer (FPC) treatments, stromal cell phenotypic and metabolic changes, hormone levels and receptor expression, immunosuppression, aberrant gene methylation, EGFR signaling, and cell-free DNA in SPC development. This comprehensive analysis contributes to elucidating current research trends in SPC mechanisms and enhances our understanding of the underlying pathophysiology. Furthermore, potential applications of intratumoral microbes, single-cell multi-omics, and metabolomics in investigating SPC mechanisms are also discussed, providing new ideas for follow-up studies. |
| format | Article |
| id | doaj-art-b1069ba3d4aa4f108cc77bbbd4848349 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-b1069ba3d4aa4f108cc77bbbd48483492025-01-26T12:50:12ZengBMCJournal of Translational Medicine1479-58762025-01-0123111810.1186/s12967-025-06151-9Decoding the mechanisms behind second primary cancersMeiyuan Zeng0Anqi Lin1Aimin Jiang2Zhengang Qiu3Hongman Zhang4Shifu Chen5Mingyan Xu6Zaoqu Liu7Quan Cheng8Jian Zhang9Peng Luo10Department of Oncology, Zhujiang Hospital, Southern Medical UniversityDepartment of Oncology, Zhujiang Hospital, Southern Medical UniversityDepartment of Urology, Changhai Hospital, Naval Medical University (Second Military Medical University)Department of Oncology, The First Affiliated Hospital of Gannan Medical UniversityDepartment of Oncology, Zhujiang Hospital, Southern Medical UniversityHaploX BiotechnologyHaploX BiotechnologyInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Neurosurgery, Xiangya Hospital, Central South UniversityDepartment of Oncology, Zhujiang Hospital, Southern Medical UniversityDepartment of Oncology, Zhujiang Hospital, Southern Medical UniversityAbstract Second Primary Cancers (SPCs) are defined as cancers that develop either simultaneously or metachronously in the same individual who has been diagnosed with and survived one primary cancer. SPCs exhibit a high incidence rate and represent the primary cause of mortality among survivors of first primary cancers. There is growing concern about the dangers of SPCs. This review summarizes recent studies on the mechanisms of SPCs, including the roles of genomic changes after first primary cancer (FPC) treatments, stromal cell phenotypic and metabolic changes, hormone levels and receptor expression, immunosuppression, aberrant gene methylation, EGFR signaling, and cell-free DNA in SPC development. This comprehensive analysis contributes to elucidating current research trends in SPC mechanisms and enhances our understanding of the underlying pathophysiology. Furthermore, potential applications of intratumoral microbes, single-cell multi-omics, and metabolomics in investigating SPC mechanisms are also discussed, providing new ideas for follow-up studies.https://doi.org/10.1186/s12967-025-06151-9Second Primary CancersMechanismsTumorigenesisImmune |
| spellingShingle | Meiyuan Zeng Anqi Lin Aimin Jiang Zhengang Qiu Hongman Zhang Shifu Chen Mingyan Xu Zaoqu Liu Quan Cheng Jian Zhang Peng Luo Decoding the mechanisms behind second primary cancers Journal of Translational Medicine Second Primary Cancers Mechanisms Tumorigenesis Immune |
| title | Decoding the mechanisms behind second primary cancers |
| title_full | Decoding the mechanisms behind second primary cancers |
| title_fullStr | Decoding the mechanisms behind second primary cancers |
| title_full_unstemmed | Decoding the mechanisms behind second primary cancers |
| title_short | Decoding the mechanisms behind second primary cancers |
| title_sort | decoding the mechanisms behind second primary cancers |
| topic | Second Primary Cancers Mechanisms Tumorigenesis Immune |
| url | https://doi.org/10.1186/s12967-025-06151-9 |
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