Aerobic exercise attenuates high-fat diet–induced renal injury through kidney metabolite modulation in mice
Purpose To investigate the preventive effect of aerobic exercise on renal damage caused by obesity.Methods The mice in the Control (Con) and Control + Exercise (Con + Ex) groups received a standard chow diet for the 21-week duration of the study, while the High-fat diet (HFD) group and High-fat diet...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2286330 |
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| author | Yingzhe Xiong Yisheng Luan Lingfeng Yuan Weihao Hong Bin Wang Hua Zhao Bing Zhang |
| author_facet | Yingzhe Xiong Yisheng Luan Lingfeng Yuan Weihao Hong Bin Wang Hua Zhao Bing Zhang |
| author_sort | Yingzhe Xiong |
| collection | DOAJ |
| description | Purpose To investigate the preventive effect of aerobic exercise on renal damage caused by obesity.Methods The mice in the Control (Con) and Control + Exercise (Con + Ex) groups received a standard chow diet for the 21-week duration of the study, while the High-fat diet (HFD) group and High-fat diet + Exercise (HFD + Ex) group were fed an HFD. Mice were acclimated to the laboratory for 1 week, given 12 weeks of being on their respective diets, and then the Con + Ex and HFD + Ex groups were subjected to moderate intensity aerobic treadmill running 45 min/day, 5 days/week for 8 weeks.Results We found that HFD-induced obesity mainly impacts kidney glycerin phospholipids, glycerides, and fatty acyls, and aerobic exercise mainly impacts kidney glycerides, amino acids and organic acids as well as their derivatives. We identified 18 metabolites with significantly altered levels that appear to be involved in aerobic exercise mediated prevention of HFD-induced obesity and renal damage, half of which were amino acids and organic acids and their derivatives.Conclusion Aerobic exercise rewires kidney metabolites to reduce high-fat diet-induced obesity and renal injury. |
| format | Article |
| id | doaj-art-b0fbe863547e492fbe0f44c2a1633db1 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-b0fbe863547e492fbe0f44c2a1633db12025-01-23T04:17:47ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2023.2286330Aerobic exercise attenuates high-fat diet–induced renal injury through kidney metabolite modulation in miceYingzhe Xiong0Yisheng Luan1Lingfeng Yuan2Weihao Hong3Bin Wang4Hua Zhao5Bing Zhang6School of Physical Education and Sports, Central China Normal University, Wuhan, ChinaDivision of Sports Science and Physical Education, Tsinghua University, Beijing, ChinaDivision of Sports Science and Physical Education, Tsinghua University, Beijing, ChinaDivision of Sports Science and Physical Education, Tsinghua University, Beijing, ChinaSchool of Physical Education and Sports, Central China Normal University, Wuhan, ChinaSchool of Physical Education and Sports, Central China Normal University, Wuhan, ChinaDivision of Sports Science and Physical Education, Tsinghua University, Beijing, ChinaPurpose To investigate the preventive effect of aerobic exercise on renal damage caused by obesity.Methods The mice in the Control (Con) and Control + Exercise (Con + Ex) groups received a standard chow diet for the 21-week duration of the study, while the High-fat diet (HFD) group and High-fat diet + Exercise (HFD + Ex) group were fed an HFD. Mice were acclimated to the laboratory for 1 week, given 12 weeks of being on their respective diets, and then the Con + Ex and HFD + Ex groups were subjected to moderate intensity aerobic treadmill running 45 min/day, 5 days/week for 8 weeks.Results We found that HFD-induced obesity mainly impacts kidney glycerin phospholipids, glycerides, and fatty acyls, and aerobic exercise mainly impacts kidney glycerides, amino acids and organic acids as well as their derivatives. We identified 18 metabolites with significantly altered levels that appear to be involved in aerobic exercise mediated prevention of HFD-induced obesity and renal damage, half of which were amino acids and organic acids and their derivatives.Conclusion Aerobic exercise rewires kidney metabolites to reduce high-fat diet-induced obesity and renal injury.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2286330Aerobic exercisepreventionobesityrenal injurymetabolomics |
| spellingShingle | Yingzhe Xiong Yisheng Luan Lingfeng Yuan Weihao Hong Bin Wang Hua Zhao Bing Zhang Aerobic exercise attenuates high-fat diet–induced renal injury through kidney metabolite modulation in mice Renal Failure Aerobic exercise prevention obesity renal injury metabolomics |
| title | Aerobic exercise attenuates high-fat diet–induced renal injury through kidney metabolite modulation in mice |
| title_full | Aerobic exercise attenuates high-fat diet–induced renal injury through kidney metabolite modulation in mice |
| title_fullStr | Aerobic exercise attenuates high-fat diet–induced renal injury through kidney metabolite modulation in mice |
| title_full_unstemmed | Aerobic exercise attenuates high-fat diet–induced renal injury through kidney metabolite modulation in mice |
| title_short | Aerobic exercise attenuates high-fat diet–induced renal injury through kidney metabolite modulation in mice |
| title_sort | aerobic exercise attenuates high fat diet induced renal injury through kidney metabolite modulation in mice |
| topic | Aerobic exercise prevention obesity renal injury metabolomics |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2286330 |
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