Abdominal Symptoms and Incident Gallstones in a Population Unaware of Gallstone Status
Introduction. Symptoms associated with newly formed gallstones have never been studied in a population unaware of their gallstones. The objective of this population-based cohort study was to determine which debut of abdominal symptoms was associated with newly formed gallstones. Materials and Method...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2016/9730687 |
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| author | Daniel Mønsted Shabanzadeh Lars Tue Sørensen Torben Jørgensen |
| author_facet | Daniel Mønsted Shabanzadeh Lars Tue Sørensen Torben Jørgensen |
| author_sort | Daniel Mønsted Shabanzadeh |
| collection | DOAJ |
| description | Introduction. Symptoms associated with newly formed gallstones have never been studied in a population unaware of their gallstones. The objective of this population-based cohort study was to determine which debut of abdominal symptoms was associated with newly formed gallstones. Materials and Methods. A cohort study was performed of a random sample from general population of Copenhagen. Participants had ultrasound examinations and answered questionnaires about abdominal symptoms at baseline and two reexaminations over 12 years. Participants were not informed of gallstone status. Inclusion criteria were no gallstones or cholecystectomy at baseline and attending a reexamination. Results. Of 3,785 participants, 2,845 fulfilled inclusion criteria. Changes in overall abdominal pain were not significantly different between incident gallstones or gallstone-free participants. Multiple adjusted logistic regression analyses showed that incident gallstones were significantly associated with debut of abdominal pain with projection, localized in the whole upper abdomen, and of longer duration. No significant associations for functional symptoms were identified. Conclusions. A new onset of abdominal pain with projection, localized in the whole upper abdomen, and of longer duration is associated with newly formed gallstones in participants unaware of gallstone status. Functional symptoms should not be the indication for surgical treatment. |
| format | Article |
| id | doaj-art-b0fb937ea0b448bdbd0853825d4bd345 |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-b0fb937ea0b448bdbd0853825d4bd3452025-02-03T06:11:16ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972016-01-01201610.1155/2016/97306879730687Abdominal Symptoms and Incident Gallstones in a Population Unaware of Gallstone StatusDaniel Mønsted Shabanzadeh0Lars Tue Sørensen1Torben Jørgensen2Digestive Disease Center, Bispebjerg University Hospital, 2400 Copenhagen, DenmarkDigestive Disease Center, Bispebjerg University Hospital, 2400 Copenhagen, DenmarkResearch Centre for Prevention and Health, Centre for Health, Capital Region, 2600 Glostrup, DenmarkIntroduction. Symptoms associated with newly formed gallstones have never been studied in a population unaware of their gallstones. The objective of this population-based cohort study was to determine which debut of abdominal symptoms was associated with newly formed gallstones. Materials and Methods. A cohort study was performed of a random sample from general population of Copenhagen. Participants had ultrasound examinations and answered questionnaires about abdominal symptoms at baseline and two reexaminations over 12 years. Participants were not informed of gallstone status. Inclusion criteria were no gallstones or cholecystectomy at baseline and attending a reexamination. Results. Of 3,785 participants, 2,845 fulfilled inclusion criteria. Changes in overall abdominal pain were not significantly different between incident gallstones or gallstone-free participants. Multiple adjusted logistic regression analyses showed that incident gallstones were significantly associated with debut of abdominal pain with projection, localized in the whole upper abdomen, and of longer duration. No significant associations for functional symptoms were identified. Conclusions. A new onset of abdominal pain with projection, localized in the whole upper abdomen, and of longer duration is associated with newly formed gallstones in participants unaware of gallstone status. Functional symptoms should not be the indication for surgical treatment.http://dx.doi.org/10.1155/2016/9730687 |
| spellingShingle | Daniel Mønsted Shabanzadeh Lars Tue Sørensen Torben Jørgensen Abdominal Symptoms and Incident Gallstones in a Population Unaware of Gallstone Status Canadian Journal of Gastroenterology and Hepatology |
| title | Abdominal Symptoms and Incident Gallstones in a Population Unaware of Gallstone Status |
| title_full | Abdominal Symptoms and Incident Gallstones in a Population Unaware of Gallstone Status |
| title_fullStr | Abdominal Symptoms and Incident Gallstones in a Population Unaware of Gallstone Status |
| title_full_unstemmed | Abdominal Symptoms and Incident Gallstones in a Population Unaware of Gallstone Status |
| title_short | Abdominal Symptoms and Incident Gallstones in a Population Unaware of Gallstone Status |
| title_sort | abdominal symptoms and incident gallstones in a population unaware of gallstone status |
| url | http://dx.doi.org/10.1155/2016/9730687 |
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