AhR governs lipid metabolism: the role of gut microbiota
The Aryl Hydrocarbon Receptor (AhR) is widely present in mammalian bodies, showing high affinity for various exogenous substances such as polycyclic aromatic hydrocarbons (PAHs) and coumarin. Under physiological conditions, AhR mainly participates in regulating the body’s immune response, cell proli...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1442282/full |
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| author | Wanru Zheng Mengkuan Liu Xinyu Lv Cuimei He Jie Yin Jie Ma |
| author_facet | Wanru Zheng Mengkuan Liu Xinyu Lv Cuimei He Jie Yin Jie Ma |
| author_sort | Wanru Zheng |
| collection | DOAJ |
| description | The Aryl Hydrocarbon Receptor (AhR) is widely present in mammalian bodies, showing high affinity for various exogenous substances such as polycyclic aromatic hydrocarbons (PAHs) and coumarin. Under physiological conditions, AhR mainly participates in regulating the body’s immune response, cell proliferation, and apoptosis among a series of processes. Recent studies have revealed a close connection between AhR and lipid metabolism. The gut microbiota plays a significant role in regulating host lipid metabolism. Growing evidence suggests an inseparable link between gut microbiota and AhR signaling. This review summarizes the relationship between AhR and lipid metabolism disorders, as well as the interaction between gut microbiota and AhR, exploring how this interaction modulates host lipid metabolism. |
| format | Article |
| id | doaj-art-b0f6d91f493e400cb477967fad4973de |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-b0f6d91f493e400cb477967fad4973de2025-01-29T16:55:48ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-01-011610.3389/fmicb.2025.14422821442282AhR governs lipid metabolism: the role of gut microbiotaWanru Zheng0Mengkuan Liu1Xinyu Lv2Cuimei He3Jie Yin4Jie Ma5College of Animal Science and Technology, Guangxi University, Nanning, ChinaCollege of Animal Science and Technology, Guangxi University, Nanning, ChinaCollege of Animal Science and Technology, Guangxi University, Nanning, ChinaCollege of Animal Science and Technology, Guangxi University, Nanning, ChinaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaCollege of Animal Science and Technology, Guangxi University, Nanning, ChinaThe Aryl Hydrocarbon Receptor (AhR) is widely present in mammalian bodies, showing high affinity for various exogenous substances such as polycyclic aromatic hydrocarbons (PAHs) and coumarin. Under physiological conditions, AhR mainly participates in regulating the body’s immune response, cell proliferation, and apoptosis among a series of processes. Recent studies have revealed a close connection between AhR and lipid metabolism. The gut microbiota plays a significant role in regulating host lipid metabolism. Growing evidence suggests an inseparable link between gut microbiota and AhR signaling. This review summarizes the relationship between AhR and lipid metabolism disorders, as well as the interaction between gut microbiota and AhR, exploring how this interaction modulates host lipid metabolism.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1442282/fullaryl hydrocarbon receptorgut microbiotalipid metabolisminflammationmetabolic disease |
| spellingShingle | Wanru Zheng Mengkuan Liu Xinyu Lv Cuimei He Jie Yin Jie Ma AhR governs lipid metabolism: the role of gut microbiota Frontiers in Microbiology aryl hydrocarbon receptor gut microbiota lipid metabolism inflammation metabolic disease |
| title | AhR governs lipid metabolism: the role of gut microbiota |
| title_full | AhR governs lipid metabolism: the role of gut microbiota |
| title_fullStr | AhR governs lipid metabolism: the role of gut microbiota |
| title_full_unstemmed | AhR governs lipid metabolism: the role of gut microbiota |
| title_short | AhR governs lipid metabolism: the role of gut microbiota |
| title_sort | ahr governs lipid metabolism the role of gut microbiota |
| topic | aryl hydrocarbon receptor gut microbiota lipid metabolism inflammation metabolic disease |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1442282/full |
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