Triterpenoids from Chios Mastiha Resin Against MASLD—A Molecular Docking Survey
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease without an approved pharmacological approach for its prevention/treatment. Based on the modified Delphi process, NAFLD was redefined as metabolic dysfunction-associated steatotic liver disease (MASLD) to highlight the...
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2025-01-01
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| author | Nataša Milošević Maja Milanović Milica Medić Stojanoska Varomyalin Tipmanee Ilias Smyrnioudis George V. Dedoussis Nataša Milić |
| author_facet | Nataša Milošević Maja Milanović Milica Medić Stojanoska Varomyalin Tipmanee Ilias Smyrnioudis George V. Dedoussis Nataša Milić |
| author_sort | Nataša Milošević |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease without an approved pharmacological approach for its prevention/treatment. Based on the modified Delphi process, NAFLD was redefined as metabolic dysfunction-associated steatotic liver disease (MASLD) to highlight the metabolic aspect of liver pathogenesis. Chios mastiha (<i>Pistacia lentiscus</i> var. <i>Chia</i>, Anacardiaceae) resin demonstrated promising results in MASLD treatment. In this paper, molecular docking was applied to test 16 compounds from Chios mastiha as potential ligands for the receptors GR, LXRα, LXRβ, PPARα PPARγ, MC4R, AMPK, and VEGFR2, whose up- and down-regulation interfere with MASLD development and progression. The observed compounds had moderate and high affinity for LXR, GR, MC4R, and PPARγ in comparison to proven ligands, while their affinity for PPARα, AMPK, and VEGFR was less pronounced. The combination of active compounds from Chios mastiha rather than a single molecule may have a superior ability to control the intertwined MASLD metabolic pathways. |
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| institution | Kabale University |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-b0d81a7341ec4dbe8a0b384e09f09b4e2025-01-24T13:27:33ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-01-014715110.3390/cimb47010051Triterpenoids from Chios Mastiha Resin Against MASLD—A Molecular Docking SurveyNataša Milošević0Maja Milanović1Milica Medić Stojanoska2Varomyalin Tipmanee3Ilias Smyrnioudis4George V. Dedoussis5Nataša Milić6Department of Pharmacy, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaDepartment of Pharmacy, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaFaculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaDepartment of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, ThailandChios Mastic Gum Growers Association, 82150 Chios, GreeceDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, 17671 Athens, GreeceDepartment of Pharmacy, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease without an approved pharmacological approach for its prevention/treatment. Based on the modified Delphi process, NAFLD was redefined as metabolic dysfunction-associated steatotic liver disease (MASLD) to highlight the metabolic aspect of liver pathogenesis. Chios mastiha (<i>Pistacia lentiscus</i> var. <i>Chia</i>, Anacardiaceae) resin demonstrated promising results in MASLD treatment. In this paper, molecular docking was applied to test 16 compounds from Chios mastiha as potential ligands for the receptors GR, LXRα, LXRβ, PPARα PPARγ, MC4R, AMPK, and VEGFR2, whose up- and down-regulation interfere with MASLD development and progression. The observed compounds had moderate and high affinity for LXR, GR, MC4R, and PPARγ in comparison to proven ligands, while their affinity for PPARα, AMPK, and VEGFR was less pronounced. The combination of active compounds from Chios mastiha rather than a single molecule may have a superior ability to control the intertwined MASLD metabolic pathways.https://www.mdpi.com/1467-3045/47/1/51non-alcoholic liver diseasenatural compoundsbiological activityantiobesitymolecular dockingmolecular target |
| spellingShingle | Nataša Milošević Maja Milanović Milica Medić Stojanoska Varomyalin Tipmanee Ilias Smyrnioudis George V. Dedoussis Nataša Milić Triterpenoids from Chios Mastiha Resin Against MASLD—A Molecular Docking Survey Current Issues in Molecular Biology non-alcoholic liver disease natural compounds biological activity antiobesity molecular docking molecular target |
| title | Triterpenoids from Chios Mastiha Resin Against MASLD—A Molecular Docking Survey |
| title_full | Triterpenoids from Chios Mastiha Resin Against MASLD—A Molecular Docking Survey |
| title_fullStr | Triterpenoids from Chios Mastiha Resin Against MASLD—A Molecular Docking Survey |
| title_full_unstemmed | Triterpenoids from Chios Mastiha Resin Against MASLD—A Molecular Docking Survey |
| title_short | Triterpenoids from Chios Mastiha Resin Against MASLD—A Molecular Docking Survey |
| title_sort | triterpenoids from chios mastiha resin against masld a molecular docking survey |
| topic | non-alcoholic liver disease natural compounds biological activity antiobesity molecular docking molecular target |
| url | https://www.mdpi.com/1467-3045/47/1/51 |
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