Neuropsychiatric Symptoms in Clinically Defined Parkinson’s Disease: An Updated Review of Literature
Background. Neuropsychiatric symptoms (NPS) are a common and potentially serious manifestation of Parkinson’s disease (PD) but are frequently overlooked in favor of a focus on motor symptomatology. Here, we conducted a literature review of the prevalence and type of NPS experienced by PD patients wi...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2022/1213393 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554972713058304 |
|---|---|
| author | Paloma Macías-García Raúl Rashid-López Álvaro J. Cruz-Gómez Elena Lozano-Soto Florencia Sanmartino Raúl Espinosa-Rosso Javier J. González-Rosa |
| author_facet | Paloma Macías-García Raúl Rashid-López Álvaro J. Cruz-Gómez Elena Lozano-Soto Florencia Sanmartino Raúl Espinosa-Rosso Javier J. González-Rosa |
| author_sort | Paloma Macías-García |
| collection | DOAJ |
| description | Background. Neuropsychiatric symptoms (NPS) are a common and potentially serious manifestation of Parkinson’s disease (PD) but are frequently overlooked in favor of a focus on motor symptomatology. Here, we conducted a literature review of the prevalence and type of NPS experienced by PD patients with a clinically defined course of their illness. Methods. We identified reports of NPS in patients with PD and mean disease duration over 3 years. Three databases—PubMed, Scopus, and Dialnet—were searched for relevant literature published between 2010 and 2020. Predefined exclusion criteria were applied prior to a descriptive analysis of the literature base. Results. In all, 87 unique reports were identified and 30 met inclusion and exclusion criteria. These included 7142 patients with PD (male: 67.3%; mean age: 66.2 years; mean disease duration: 6.7 years). The most frequent NPS were mood disorders (apathy, depression, and anxiety), psychosis, and impulse control disorders (ICD). Treatment with dopamine agonists was identified as an important risk factor for ICD. Co-occurrence of NPS and cognitive dysfunction was also evidenced in a number of studies. Patients with more significant cognitive deficits and higher levels of NPS appeared to be of older age with a longer disease duration and to have more severe motor symptoms. Conclusions. NPS, most commonly mood disorders (apathy, depression, and anxiety), psychosis, and ICDs are frequent manifestations of PD. The results of this review reflect the need to develop unified validated assessment protocols for NPS in PD, as well as to improve their management in clinical practice. |
| format | Article |
| id | doaj-art-b0d695b202a148659c588a9ef3e909cf |
| institution | Kabale University |
| issn | 1875-8584 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-b0d695b202a148659c588a9ef3e909cf2025-02-03T05:49:59ZengWileyBehavioural Neurology1875-85842022-01-01202210.1155/2022/1213393Neuropsychiatric Symptoms in Clinically Defined Parkinson’s Disease: An Updated Review of LiteraturePaloma Macías-García0Raúl Rashid-López1Álvaro J. Cruz-Gómez2Elena Lozano-Soto3Florencia Sanmartino4Raúl Espinosa-Rosso5Javier J. González-Rosa6Institute of Biomedical Research Cadiz (INIBICA)Institute of Biomedical Research Cadiz (INIBICA)Institute of Biomedical Research Cadiz (INIBICA)Institute of Biomedical Research Cadiz (INIBICA)Institute of Biomedical Research Cadiz (INIBICA)Institute of Biomedical Research Cadiz (INIBICA)Institute of Biomedical Research Cadiz (INIBICA)Background. Neuropsychiatric symptoms (NPS) are a common and potentially serious manifestation of Parkinson’s disease (PD) but are frequently overlooked in favor of a focus on motor symptomatology. Here, we conducted a literature review of the prevalence and type of NPS experienced by PD patients with a clinically defined course of their illness. Methods. We identified reports of NPS in patients with PD and mean disease duration over 3 years. Three databases—PubMed, Scopus, and Dialnet—were searched for relevant literature published between 2010 and 2020. Predefined exclusion criteria were applied prior to a descriptive analysis of the literature base. Results. In all, 87 unique reports were identified and 30 met inclusion and exclusion criteria. These included 7142 patients with PD (male: 67.3%; mean age: 66.2 years; mean disease duration: 6.7 years). The most frequent NPS were mood disorders (apathy, depression, and anxiety), psychosis, and impulse control disorders (ICD). Treatment with dopamine agonists was identified as an important risk factor for ICD. Co-occurrence of NPS and cognitive dysfunction was also evidenced in a number of studies. Patients with more significant cognitive deficits and higher levels of NPS appeared to be of older age with a longer disease duration and to have more severe motor symptoms. Conclusions. NPS, most commonly mood disorders (apathy, depression, and anxiety), psychosis, and ICDs are frequent manifestations of PD. The results of this review reflect the need to develop unified validated assessment protocols for NPS in PD, as well as to improve their management in clinical practice.http://dx.doi.org/10.1155/2022/1213393 |
| spellingShingle | Paloma Macías-García Raúl Rashid-López Álvaro J. Cruz-Gómez Elena Lozano-Soto Florencia Sanmartino Raúl Espinosa-Rosso Javier J. González-Rosa Neuropsychiatric Symptoms in Clinically Defined Parkinson’s Disease: An Updated Review of Literature Behavioural Neurology |
| title | Neuropsychiatric Symptoms in Clinically Defined Parkinson’s Disease: An Updated Review of Literature |
| title_full | Neuropsychiatric Symptoms in Clinically Defined Parkinson’s Disease: An Updated Review of Literature |
| title_fullStr | Neuropsychiatric Symptoms in Clinically Defined Parkinson’s Disease: An Updated Review of Literature |
| title_full_unstemmed | Neuropsychiatric Symptoms in Clinically Defined Parkinson’s Disease: An Updated Review of Literature |
| title_short | Neuropsychiatric Symptoms in Clinically Defined Parkinson’s Disease: An Updated Review of Literature |
| title_sort | neuropsychiatric symptoms in clinically defined parkinson s disease an updated review of literature |
| url | http://dx.doi.org/10.1155/2022/1213393 |
| work_keys_str_mv | AT palomamaciasgarcia neuropsychiatricsymptomsinclinicallydefinedparkinsonsdiseaseanupdatedreviewofliterature AT raulrashidlopez neuropsychiatricsymptomsinclinicallydefinedparkinsonsdiseaseanupdatedreviewofliterature AT alvarojcruzgomez neuropsychiatricsymptomsinclinicallydefinedparkinsonsdiseaseanupdatedreviewofliterature AT elenalozanosoto neuropsychiatricsymptomsinclinicallydefinedparkinsonsdiseaseanupdatedreviewofliterature AT florenciasanmartino neuropsychiatricsymptomsinclinicallydefinedparkinsonsdiseaseanupdatedreviewofliterature AT raulespinosarosso neuropsychiatricsymptomsinclinicallydefinedparkinsonsdiseaseanupdatedreviewofliterature AT javierjgonzalezrosa neuropsychiatricsymptomsinclinicallydefinedparkinsonsdiseaseanupdatedreviewofliterature |