MRI-based machine learning reveals proteasome subunit PSMB8-mediated malignant glioma phenotypes through activating TGFBR1/2-SMAD2/3 axis

MRI-based machine learning reveals proteasome subunit PSMB8-mediated malignant glioma phenotypes through activating TGFBR1/2-SMAD2/3 axis

Abstract Gliomas are the most prevalent and aggressive neoplasms of the central nervous system, representing a major challenge for effective treatment and patient prognosis. This study identifies the proteasome subunit beta type-8 (PSMB8/LMP7) as a promising prognostic biomarker for glioma. Using a...

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Bibliographic Details
Main Authors: Dongling Pei, Zeyu Ma, Yuning Qiu, Minkai Wang, Zilong Wang, Xianzhi Liu, Long Zhang, Zhenyu Zhang, Ran Li, Dongming Yan
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Molecular Biomedicine
Subjects:
Glioma
Proteasome subunit beta type-8 (PSMB8)
Proliferation
Apoptosis
Radiomics
Online Access:https://doi.org/10.1186/s43556-025-00268-5
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