Hypertension and Dementia in the Elderly: The Leisure World Cohort Study
Recent studies have highlighted the deleterious role of cardiovascular risk factors, including hypertension, on the incidence of dementia. Although midlife hypertension is associated with later development of dementia, the role of late-life hypertension remains unclear. We explored the association o...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/205350 |
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| author | Annlia Paganini-Hill |
| author_facet | Annlia Paganini-Hill |
| author_sort | Annlia Paganini-Hill |
| collection | DOAJ |
| description | Recent studies have highlighted the deleterious role of cardiovascular risk factors, including hypertension, on the incidence of dementia. Although midlife hypertension is associated with later development of dementia, the role of late-life hypertension remains unclear. We explored the association of hypertension and its treatment with incident dementia in 13978 older (median = 74 years) adults followed from 1981 to 2010 (median = 13 years) and calculated risk estimates using Cox regression analysis in two age groups (<75 and 75+ years) in men and women separately. Dementia status was determined from in-person evaluations, followup questionnaires, hospital data, and death certificates. In the older women, current users of blood pressure medication at baseline had a 26% increased risk of dementia (95% CI 1.06–1.51). In the younger men, those with untreated hypertension and those with past use of blood pressure medication use had about a 30% nonsignificant increased risk of dementia. High blood pressure and its treatment appear to have different effects in men and women and in the old and older. |
| format | Article |
| id | doaj-art-b0832fe744384e4b992ce227192f7b3d |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-b0832fe744384e4b992ce227192f7b3d2025-02-03T01:25:04ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/205350205350Hypertension and Dementia in the Elderly: The Leisure World Cohort StudyAnnlia Paganini-Hill0Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USARecent studies have highlighted the deleterious role of cardiovascular risk factors, including hypertension, on the incidence of dementia. Although midlife hypertension is associated with later development of dementia, the role of late-life hypertension remains unclear. We explored the association of hypertension and its treatment with incident dementia in 13978 older (median = 74 years) adults followed from 1981 to 2010 (median = 13 years) and calculated risk estimates using Cox regression analysis in two age groups (<75 and 75+ years) in men and women separately. Dementia status was determined from in-person evaluations, followup questionnaires, hospital data, and death certificates. In the older women, current users of blood pressure medication at baseline had a 26% increased risk of dementia (95% CI 1.06–1.51). In the younger men, those with untreated hypertension and those with past use of blood pressure medication use had about a 30% nonsignificant increased risk of dementia. High blood pressure and its treatment appear to have different effects in men and women and in the old and older.http://dx.doi.org/10.1155/2012/205350 |
| spellingShingle | Annlia Paganini-Hill Hypertension and Dementia in the Elderly: The Leisure World Cohort Study International Journal of Hypertension |
| title | Hypertension and Dementia in the Elderly: The Leisure World Cohort Study |
| title_full | Hypertension and Dementia in the Elderly: The Leisure World Cohort Study |
| title_fullStr | Hypertension and Dementia in the Elderly: The Leisure World Cohort Study |
| title_full_unstemmed | Hypertension and Dementia in the Elderly: The Leisure World Cohort Study |
| title_short | Hypertension and Dementia in the Elderly: The Leisure World Cohort Study |
| title_sort | hypertension and dementia in the elderly the leisure world cohort study |
| url | http://dx.doi.org/10.1155/2012/205350 |
| work_keys_str_mv | AT annliapaganinihill hypertensionanddementiaintheelderlytheleisureworldcohortstudy |