Primary large cell neuroendocrine carcinoma of the urethra: a case report
BackgroundPrimary neuroendocrine carcinoma of the urethra is a very uncommon malignant tumor, and no reports have been made about large cell neuroendocrine carcinoma (LCNEC) in the past.Case descriptionA 43-year-old non-smoking female patient presented with symptoms of dysuria and urination-related...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Urology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fruro.2025.1440538/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832087164187312128 |
|---|---|
| author | Jianbai Chen Xiaorong Mou Zhiming Zhang Zhiyong Nie Jianxin Qiu |
| author_facet | Jianbai Chen Xiaorong Mou Zhiming Zhang Zhiyong Nie Jianxin Qiu |
| author_sort | Jianbai Chen |
| collection | DOAJ |
| description | BackgroundPrimary neuroendocrine carcinoma of the urethra is a very uncommon malignant tumor, and no reports have been made about large cell neuroendocrine carcinoma (LCNEC) in the past.Case descriptionA 43-year-old non-smoking female patient presented with symptoms of dysuria and urination-related pain at TangDu Hospital in April 2022. A biopsy subsequently confirmed the diagnosis of primary urethral LCNEC. Following radical resection, the patient exhibited abnormal lymph node enlargement in the first month and pelvic metastases in the fourth month. Ultimately, the patient succumbed to the disease 486 days after the radical resection, attributed to widespread tumor metastases and concurrent multi-organ failure. The final pathological examination confirmed the presence of a high-grade LCNEC.ConclusionThe occurrence of primary LCNEC in the urethra is exceptionally uncommon. This particular instance was notable for its aggressive progression and unfavorable prognosis. Historically, there have been no prior documented instances of primary pure LCNEC in the urethra. It is imperative to emphasize that early identification and intervention for LCNEC could potentially offer patients a more favorable survival outcome. |
| format | Article |
| id | doaj-art-b07d6e4f5bb2471c8c16a01799dd9106 |
| institution | Kabale University |
| issn | 2673-9828 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Urology |
| spelling | doaj-art-b07d6e4f5bb2471c8c16a01799dd91062025-02-06T07:10:13ZengFrontiers Media S.A.Frontiers in Urology2673-98282025-02-01510.3389/fruro.2025.14405381440538Primary large cell neuroendocrine carcinoma of the urethra: a case reportJianbai Chen0Xiaorong Mou1Zhiming Zhang2Zhiyong Nie3Jianxin Qiu4Air Force Medical University, Xi’an, ChinaDepartment of Pathology, Tangdu Hospital, Xi’an, ChinaDepartment of Urology, Tangdu Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Urology, Tangdu Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Urology, Tangdu Hospital, Fourth Military Medical University, Xi’an, ChinaBackgroundPrimary neuroendocrine carcinoma of the urethra is a very uncommon malignant tumor, and no reports have been made about large cell neuroendocrine carcinoma (LCNEC) in the past.Case descriptionA 43-year-old non-smoking female patient presented with symptoms of dysuria and urination-related pain at TangDu Hospital in April 2022. A biopsy subsequently confirmed the diagnosis of primary urethral LCNEC. Following radical resection, the patient exhibited abnormal lymph node enlargement in the first month and pelvic metastases in the fourth month. Ultimately, the patient succumbed to the disease 486 days after the radical resection, attributed to widespread tumor metastases and concurrent multi-organ failure. The final pathological examination confirmed the presence of a high-grade LCNEC.ConclusionThe occurrence of primary LCNEC in the urethra is exceptionally uncommon. This particular instance was notable for its aggressive progression and unfavorable prognosis. Historically, there have been no prior documented instances of primary pure LCNEC in the urethra. It is imperative to emphasize that early identification and intervention for LCNEC could potentially offer patients a more favorable survival outcome.https://www.frontiersin.org/articles/10.3389/fruro.2025.1440538/fulllarge cell neuroendocrine carcinomaurethra carcinomacase reportprognosisradical cystectomy (RC) |
| spellingShingle | Jianbai Chen Xiaorong Mou Zhiming Zhang Zhiyong Nie Jianxin Qiu Primary large cell neuroendocrine carcinoma of the urethra: a case report Frontiers in Urology large cell neuroendocrine carcinoma urethra carcinoma case report prognosis radical cystectomy (RC) |
| title | Primary large cell neuroendocrine carcinoma of the urethra: a case report |
| title_full | Primary large cell neuroendocrine carcinoma of the urethra: a case report |
| title_fullStr | Primary large cell neuroendocrine carcinoma of the urethra: a case report |
| title_full_unstemmed | Primary large cell neuroendocrine carcinoma of the urethra: a case report |
| title_short | Primary large cell neuroendocrine carcinoma of the urethra: a case report |
| title_sort | primary large cell neuroendocrine carcinoma of the urethra a case report |
| topic | large cell neuroendocrine carcinoma urethra carcinoma case report prognosis radical cystectomy (RC) |
| url | https://www.frontiersin.org/articles/10.3389/fruro.2025.1440538/full |
| work_keys_str_mv | AT jianbaichen primarylargecellneuroendocrinecarcinomaoftheurethraacasereport AT xiaorongmou primarylargecellneuroendocrinecarcinomaoftheurethraacasereport AT zhimingzhang primarylargecellneuroendocrinecarcinomaoftheurethraacasereport AT zhiyongnie primarylargecellneuroendocrinecarcinomaoftheurethraacasereport AT jianxinqiu primarylargecellneuroendocrinecarcinomaoftheurethraacasereport |