Prediction of lung overdistension during mechanical ventilation using micro-RNA and gene expression

Prediction of lung overdistension during mechanical ventilation using micro-RNA and gene expression

Abstract Background Overstretching of lung parenchyma may lead to injury, especially during mechanical ventilation. To date, there are no specific biomarkers of lung stretch, but transcriptomic signatures have not been explored. Our objective was to identify stretch-specific signatures using micro-R...

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Main Authors: Cecilia López-Martínez, Paula Martín-Vicente, Laura Amado-Rodríguez, Inés López-Alonso, Margarita Fernández-Rodríguez, Adrián González-López, Pablo Martínez-Camblor, Juan Gómez, Andrew J. Boyle, Cecilia M. O’Kane, Daniel F. McAuley, James N. Tsoporis, Claudia dos Santos, Guillermo M. Albaiceta
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:Intensive Care Medicine Experimental
Subjects:
Lung stretch
Transcriptomics
Micro-RNAs
Overdistension
Online Access:https://doi.org/10.1186/s40635-025-00768-2
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