Neutrophil extracellular traps in diseases of the female reproductive organs
Neutrophil extracellular traps (NETs) are physiologically released in response to pathogens, serving as a defense mechanism. However, excessive NET production has been implicated in various pathological conditions, including diseases of the female reproductive system. Recent studies highlight the si...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589329/full |
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| author | Maria-Laura Morawiec Robert Kubina Robert Kubina Sebastian Stępień Marta Smycz-Kubańska Patrycja Królewska-Daszczyńska Wioletta Ratajczak-Wrona Aleksandra Mielczarek-Palacz |
| author_facet | Maria-Laura Morawiec Robert Kubina Robert Kubina Sebastian Stępień Marta Smycz-Kubańska Patrycja Królewska-Daszczyńska Wioletta Ratajczak-Wrona Aleksandra Mielczarek-Palacz |
| author_sort | Maria-Laura Morawiec |
| collection | DOAJ |
| description | Neutrophil extracellular traps (NETs) are physiologically released in response to pathogens, serving as a defense mechanism. However, excessive NET production has been implicated in various pathological conditions, including diseases of the female reproductive system. Recent studies highlight the significant role of neutrophils and NETs in cancer pathogenesis. Overproduction of NETs creates sites for tumor cell adhesion, promoting tumor cell proliferation, immune escape, and tumor progression. NET formation is associated with many diseases, including cancers of the female reproductive organs. Detection of NETs can be used as a prognostic tool for patients with diseases characterized by higher rates of NETs formation, such as cancer. In order to use NETs in diagnosis, it is possible to determine them directly or to determine NET components: extracellular DNA, citrullinated histones, NE or MPO. This review explores the role of neutrophils and NETs in the pathogenesis, diagnosis and treatment of breast, ovarian, cervical and endometrial cancer, premature lapse of ovarian function, cervicitis, endometriosis, pregnancy and pregnancy-related diseases. |
| format | Article |
| id | doaj-art-b072dc1d0845404f9de9d4be91e13bb7 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-b072dc1d0845404f9de9d4be91e13bb72025-08-20T02:11:13ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15893291589329Neutrophil extracellular traps in diseases of the female reproductive organsMaria-Laura Morawiec0Robert Kubina1Robert Kubina2Sebastian Stępień3Marta Smycz-Kubańska4Patrycja Królewska-Daszczyńska5Wioletta Ratajczak-Wrona6Aleksandra Mielczarek-Palacz7Department of Immunology and Serology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Katowice, PolandSilesia LabMed: Centre for Research and Implementation, Medical University of Silesia in Katowice, Katowice, PolandDepartment of Pathology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Katowice, PolandDepartment of Immunology and Serology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Katowice, PolandDepartment of Immunology and Serology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Katowice, PolandDepartment of Immunology and Serology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Katowice, PolandDepartment of Immunology, Medical University of Bialystok, Białystok, PolandDepartment of Immunology and Serology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Katowice, PolandNeutrophil extracellular traps (NETs) are physiologically released in response to pathogens, serving as a defense mechanism. However, excessive NET production has been implicated in various pathological conditions, including diseases of the female reproductive system. Recent studies highlight the significant role of neutrophils and NETs in cancer pathogenesis. Overproduction of NETs creates sites for tumor cell adhesion, promoting tumor cell proliferation, immune escape, and tumor progression. NET formation is associated with many diseases, including cancers of the female reproductive organs. Detection of NETs can be used as a prognostic tool for patients with diseases characterized by higher rates of NETs formation, such as cancer. In order to use NETs in diagnosis, it is possible to determine them directly or to determine NET components: extracellular DNA, citrullinated histones, NE or MPO. This review explores the role of neutrophils and NETs in the pathogenesis, diagnosis and treatment of breast, ovarian, cervical and endometrial cancer, premature lapse of ovarian function, cervicitis, endometriosis, pregnancy and pregnancy-related diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589329/fullNETsneutrophilsgynecological cancergynecological diseasesbreast cancer |
| spellingShingle | Maria-Laura Morawiec Robert Kubina Robert Kubina Sebastian Stępień Marta Smycz-Kubańska Patrycja Królewska-Daszczyńska Wioletta Ratajczak-Wrona Aleksandra Mielczarek-Palacz Neutrophil extracellular traps in diseases of the female reproductive organs Frontiers in Immunology NETs neutrophils gynecological cancer gynecological diseases breast cancer |
| title | Neutrophil extracellular traps in diseases of the female reproductive organs |
| title_full | Neutrophil extracellular traps in diseases of the female reproductive organs |
| title_fullStr | Neutrophil extracellular traps in diseases of the female reproductive organs |
| title_full_unstemmed | Neutrophil extracellular traps in diseases of the female reproductive organs |
| title_short | Neutrophil extracellular traps in diseases of the female reproductive organs |
| title_sort | neutrophil extracellular traps in diseases of the female reproductive organs |
| topic | NETs neutrophils gynecological cancer gynecological diseases breast cancer |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589329/full |
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