Effects of esculentoside A on turnour necrosis factor production by mice peritoneal macrophages
Esculentoside A (EsA) is a saponin isolated from the roots of Phytolacca esculenta. Previous experiments showed that it had strong anti-inflammatory effects. Tumour necrosis factor (TNF) is an important inflammatory mediator. In order to study the mechanism of the anti-inflammatory effect of EsA, it...
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| Format: | Article |
| Language: | English |
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Wiley
1992-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935192000565 |
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| _version_ | 1832549254599540736 |
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| author | Fang Jun Zheng Qin Yue Wang Hong Bin Ju Dian Wen Yi Yang Hua |
| author_facet | Fang Jun Zheng Qin Yue Wang Hong Bin Ju Dian Wen Yi Yang Hua |
| author_sort | Fang Jun |
| collection | DOAJ |
| description | Esculentoside A (EsA) is a saponin isolated from the roots of Phytolacca esculenta. Previous experiments showed that it had strong anti-inflammatory effects. Tumour necrosis factor (TNF) is an important inflammatory mediator. In order to study the mechanism of the anti-inflammatory effect of EsA, it was determined whether TNF production from macrophages was altered by EsA under lipopolysaccharide (LPS) stimulated conditions. EsA was found to decrease both extracellular and cell associated TNF production in a dose dependent manner at concentrations higher than 1 μmol/l EsA. Previous studies have showed that EsA reduced the releasing of platelet activating factor (PAF) from rat macrophages. The reducing effects of EsA on the release of TNF and PAF may explain its anti-inflammatory effect. |
| format | Article |
| id | doaj-art-b069f01634494a8f9d8a81f434f96c48 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b069f01634494a8f9d8a81f434f96c482025-02-03T06:11:48ZengWileyMediators of Inflammation0962-93511466-18611992-01-011637537710.1155/S0962935192000565Effects of esculentoside A on turnour necrosis factor production by mice peritoneal macrophagesFang Jun0Zheng Qin Yue1Wang Hong Bin2Ju Dian Wen3Yi Yang Hua4Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, ChinaDepartment of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, ChinaDepartment of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, ChinaDepartment of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, ChinaDepartment of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, ChinaEsculentoside A (EsA) is a saponin isolated from the roots of Phytolacca esculenta. Previous experiments showed that it had strong anti-inflammatory effects. Tumour necrosis factor (TNF) is an important inflammatory mediator. In order to study the mechanism of the anti-inflammatory effect of EsA, it was determined whether TNF production from macrophages was altered by EsA under lipopolysaccharide (LPS) stimulated conditions. EsA was found to decrease both extracellular and cell associated TNF production in a dose dependent manner at concentrations higher than 1 μmol/l EsA. Previous studies have showed that EsA reduced the releasing of platelet activating factor (PAF) from rat macrophages. The reducing effects of EsA on the release of TNF and PAF may explain its anti-inflammatory effect.http://dx.doi.org/10.1155/S0962935192000565 |
| spellingShingle | Fang Jun Zheng Qin Yue Wang Hong Bin Ju Dian Wen Yi Yang Hua Effects of esculentoside A on turnour necrosis factor production by mice peritoneal macrophages Mediators of Inflammation |
| title | Effects of esculentoside A on turnour necrosis factor production by mice peritoneal macrophages |
| title_full | Effects of esculentoside A on turnour necrosis factor production by mice peritoneal macrophages |
| title_fullStr | Effects of esculentoside A on turnour necrosis factor production by mice peritoneal macrophages |
| title_full_unstemmed | Effects of esculentoside A on turnour necrosis factor production by mice peritoneal macrophages |
| title_short | Effects of esculentoside A on turnour necrosis factor production by mice peritoneal macrophages |
| title_sort | effects of esculentoside a on turnour necrosis factor production by mice peritoneal macrophages |
| url | http://dx.doi.org/10.1155/S0962935192000565 |
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