Fabrication of an In Situ pH-Responsive Raloxifene-Loaded Invasome Hydrogel for Breast Cancer Management: In Vitro and In Vivo Evaluation

Fabrication of an In Situ pH-Responsive Raloxifene-Loaded Invasome Hydrogel for Breast Cancer Management: In Vitro and In Vivo Evaluation

Background/Objectives: Raloxifene (RLF) is a therapeutic option for invasive breast cancer because it blocks estrogen receptors selectively. Low solubility, limited targeting, first-pass action, and poor absorption are some of the challenges that make RLF in oral form less effective. This study aime...

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Bibliographic Details
Main Authors: Hanan O. Farouk, Marwa M. Nagib, Amr Gamal Fouad, Demiana M. Naguib, Sherif Faysal Abdelfattah Khalil, Amany Belal, Samar F. Miski, Nisreen Khalid Aref Albezrah, Shatha Hallal Al-Ziyadi, Gi-Hui Kim, Ahmed H. E. Hassan, Kyung-Tae Lee, Doaa S. Hamad
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceuticals
Subjects:
breast cancer
raloxifene
invasomes
bioavailability
chitosan
targeting
Online Access:https://www.mdpi.com/1424-8247/17/11/1518
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