Effect of endoscopic ultrasound guided gastric botulinum toxin injections and glucagon like peptide 1 receptor agonist on weight loss
Abstract In study, we compared safety, feasibility, and efficacy of endoscopic ultrasound (EUS) guided botulinum toxin A (BTA) injection versus glucagon like peptide 1 (GLP-1) agonists in treatment of obesity. The two intervention techniques were paired with a number of lifestyle changes, such as a...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-04-01
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| Series: | The Egyptian Journal of Internal Medicine |
| Online Access: | https://doi.org/10.1186/s43162-025-00443-8 |
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| author | Asmaa Gameel Ahmed Altonbary Fady Kyrillos Aya Elbialy |
| author_facet | Asmaa Gameel Ahmed Altonbary Fady Kyrillos Aya Elbialy |
| author_sort | Asmaa Gameel |
| collection | DOAJ |
| description | Abstract In study, we compared safety, feasibility, and efficacy of endoscopic ultrasound (EUS) guided botulinum toxin A (BTA) injection versus glucagon like peptide 1 (GLP-1) agonists in treatment of obesity. The two intervention techniques were paired with a number of lifestyle changes, such as a diet of 2000 cal per day for males and 1800 cal per day for women, and moderate daily cardiovascular exercise (at least 30 min, 5 days a week) for 4 months. Over the course of a 16-week follow-up period, body weight was measured. Forty patients were included in this study, 20 in each group. The 1st group underwent BTA injections via EUS, while the 2nd group received GLP 1 receptor agonist. In the 1st group, there was a significant weight loss from (107.30 ± 11.41 kg) at baseline to (94.75 ± 12.65 kg) after 4 months of treatment (p value < 0.001). In the 2nd, there was significant weight loss from (123.28 ± 17.17 kg) at baseline to (109.75 ± 14.37 kg) after 4 months (p value < 0.001). Significant reduction of BMI was reported in both groups after 4 months of treatment; 1st group, from (40.53 ± 4.41 kg/m2) at baseline to (35.78 ± 4.82 kg/m2) (p value < 0.001), 2nd group from (44.15 ± 5.94 kg/m2) to (39.40 ± 5.68 kg/m2) (p value < 0.001). Both measures are effective, but we have to consider the invasiveness of the first one and the systemic side effects of the second procedure. Trial registration: NCT05268627, First registration date (27/03/2022). |
| format | Article |
| id | doaj-art-b052d75e7e274697bf1d6320f579c7e9 |
| institution | OA Journals |
| issn | 2090-9098 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Internal Medicine |
| spelling | doaj-art-b052d75e7e274697bf1d6320f579c7e92025-08-20T02:28:08ZengSpringerOpenThe Egyptian Journal of Internal Medicine2090-90982025-04-013711910.1186/s43162-025-00443-8Effect of endoscopic ultrasound guided gastric botulinum toxin injections and glucagon like peptide 1 receptor agonist on weight lossAsmaa Gameel0Ahmed Altonbary1Fady Kyrillos2Aya Elbialy3Mansoura UniversityMansoura UniversityMansoura UniversityMansoura UniversityAbstract In study, we compared safety, feasibility, and efficacy of endoscopic ultrasound (EUS) guided botulinum toxin A (BTA) injection versus glucagon like peptide 1 (GLP-1) agonists in treatment of obesity. The two intervention techniques were paired with a number of lifestyle changes, such as a diet of 2000 cal per day for males and 1800 cal per day for women, and moderate daily cardiovascular exercise (at least 30 min, 5 days a week) for 4 months. Over the course of a 16-week follow-up period, body weight was measured. Forty patients were included in this study, 20 in each group. The 1st group underwent BTA injections via EUS, while the 2nd group received GLP 1 receptor agonist. In the 1st group, there was a significant weight loss from (107.30 ± 11.41 kg) at baseline to (94.75 ± 12.65 kg) after 4 months of treatment (p value < 0.001). In the 2nd, there was significant weight loss from (123.28 ± 17.17 kg) at baseline to (109.75 ± 14.37 kg) after 4 months (p value < 0.001). Significant reduction of BMI was reported in both groups after 4 months of treatment; 1st group, from (40.53 ± 4.41 kg/m2) at baseline to (35.78 ± 4.82 kg/m2) (p value < 0.001), 2nd group from (44.15 ± 5.94 kg/m2) to (39.40 ± 5.68 kg/m2) (p value < 0.001). Both measures are effective, but we have to consider the invasiveness of the first one and the systemic side effects of the second procedure. Trial registration: NCT05268627, First registration date (27/03/2022).https://doi.org/10.1186/s43162-025-00443-8 |
| spellingShingle | Asmaa Gameel Ahmed Altonbary Fady Kyrillos Aya Elbialy Effect of endoscopic ultrasound guided gastric botulinum toxin injections and glucagon like peptide 1 receptor agonist on weight loss The Egyptian Journal of Internal Medicine |
| title | Effect of endoscopic ultrasound guided gastric botulinum toxin injections and glucagon like peptide 1 receptor agonist on weight loss |
| title_full | Effect of endoscopic ultrasound guided gastric botulinum toxin injections and glucagon like peptide 1 receptor agonist on weight loss |
| title_fullStr | Effect of endoscopic ultrasound guided gastric botulinum toxin injections and glucagon like peptide 1 receptor agonist on weight loss |
| title_full_unstemmed | Effect of endoscopic ultrasound guided gastric botulinum toxin injections and glucagon like peptide 1 receptor agonist on weight loss |
| title_short | Effect of endoscopic ultrasound guided gastric botulinum toxin injections and glucagon like peptide 1 receptor agonist on weight loss |
| title_sort | effect of endoscopic ultrasound guided gastric botulinum toxin injections and glucagon like peptide 1 receptor agonist on weight loss |
| url | https://doi.org/10.1186/s43162-025-00443-8 |
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