Factors Associated with the Occurrence of 0PN Fertilization in in Vitro Fertilization and its Effects on Embryo Development and Reproductive Outcomes
Background: To investigate factors associated with the occurrence of nonpronuclear (0PN) fertilization and to determine its effects on embryo development and reproductive outcomes in conventional in vitro fertilization (cIVF). Methods: This retrospective cohort study included 1116 IVF cycles and the...
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IMR Press
2024-02-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/51/2/10.31083/j.ceog5102032 |
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| author | Hongmin Guo Xinhui Sun Yueyue Jia Jing Du |
| author_facet | Hongmin Guo Xinhui Sun Yueyue Jia Jing Du |
| author_sort | Hongmin Guo |
| collection | DOAJ |
| description | Background: To investigate factors associated with the occurrence of nonpronuclear (0PN) fertilization and to determine its effects on embryo development and reproductive outcomes in conventional in vitro fertilization (cIVF). Methods: This retrospective cohort study included 1116 IVF cycles and the corresponding 535 fresh transfer cycles performed during 2016–2022. Patients were divided into 0PN (+) (n = 279) and 0PN (–) (n = 837) groups based on whether they had embryos with 0PN fertilization. A multiple logistic regression model was used to determine confounders that could affect 0PN fertilization. Additionally, embryo development and reproductive outcomes were compared between the 0PN (+) and 0PN (–) groups, as well as between the 0PN embryo (n = 563) and two pronuclear (2PN) embryo (n = 1976) groups. Results: The number of mature oocytes was significantly correlated with the occurrence of 0PN fertilization (odds ratio: 1.15; 95% confidence interval 1.04–1.27; p = 0.007). The top-quality embryo rate was significantly higher in the 0PN (+) group than in the 0PN (–) group (52.9% vs. 49.9%; p = 0.024). Clinical outcomes were similar between these groups in terms of clinical pregnancy rates (43.1% vs. 45.5%), implantation rates (35.0% vs. 34.1%), miscarriage rates (15.3% vs. 17.1%), and live birth rates (33.6% vs. 33.9%). The top-quality embryo rates (45.3% vs. 52.9%, p = 0.001) and blastulation rates (57.7% vs. 63.8%, p = 0.023) were significantly lower in 0PN embryos than in 2PN embryos. The clinical outcomes were also similar between these groups. Conclusions: The number of mature oocytes is significantly correlated with the occurrence of 0PN fertilization in cIVF. 0PN fertilization does not affect reproductive outcomes during fresh transfer cycles. |
| format | Article |
| id | doaj-art-b04e2bf239d3473bafc8096bd2f69a6f |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | IMR Press |
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| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-b04e2bf239d3473bafc8096bd2f69a6f2025-08-20T01:59:56ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632024-02-015123210.31083/j.ceog5102032S0390-6663(23)02265-0Factors Associated with the Occurrence of 0PN Fertilization in in Vitro Fertilization and its Effects on Embryo Development and Reproductive OutcomesHongmin Guo0Xinhui Sun1Yueyue Jia2Jing Du3Reproductive Medical Center, Liaocheng People's Hospital, 252000 Liaocheng, Shandong, ChinaReproductive Medical Center, Liaocheng People's Hospital, 252000 Liaocheng, Shandong, ChinaReproductive Medical Center, Liaocheng People's Hospital, 252000 Liaocheng, Shandong, ChinaReproductive Medical Center, Liaocheng People's Hospital, 252000 Liaocheng, Shandong, ChinaBackground: To investigate factors associated with the occurrence of nonpronuclear (0PN) fertilization and to determine its effects on embryo development and reproductive outcomes in conventional in vitro fertilization (cIVF). Methods: This retrospective cohort study included 1116 IVF cycles and the corresponding 535 fresh transfer cycles performed during 2016–2022. Patients were divided into 0PN (+) (n = 279) and 0PN (–) (n = 837) groups based on whether they had embryos with 0PN fertilization. A multiple logistic regression model was used to determine confounders that could affect 0PN fertilization. Additionally, embryo development and reproductive outcomes were compared between the 0PN (+) and 0PN (–) groups, as well as between the 0PN embryo (n = 563) and two pronuclear (2PN) embryo (n = 1976) groups. Results: The number of mature oocytes was significantly correlated with the occurrence of 0PN fertilization (odds ratio: 1.15; 95% confidence interval 1.04–1.27; p = 0.007). The top-quality embryo rate was significantly higher in the 0PN (+) group than in the 0PN (–) group (52.9% vs. 49.9%; p = 0.024). Clinical outcomes were similar between these groups in terms of clinical pregnancy rates (43.1% vs. 45.5%), implantation rates (35.0% vs. 34.1%), miscarriage rates (15.3% vs. 17.1%), and live birth rates (33.6% vs. 33.9%). The top-quality embryo rates (45.3% vs. 52.9%, p = 0.001) and blastulation rates (57.7% vs. 63.8%, p = 0.023) were significantly lower in 0PN embryos than in 2PN embryos. The clinical outcomes were also similar between these groups. Conclusions: The number of mature oocytes is significantly correlated with the occurrence of 0PN fertilization in cIVF. 0PN fertilization does not affect reproductive outcomes during fresh transfer cycles.https://www.imrpress.com/journal/CEOG/51/2/10.31083/j.ceog5102032nonpronuclear fertilizationin vitro fertilizationembryo developmentembryo transferpregnancy |
| spellingShingle | Hongmin Guo Xinhui Sun Yueyue Jia Jing Du Factors Associated with the Occurrence of 0PN Fertilization in in Vitro Fertilization and its Effects on Embryo Development and Reproductive Outcomes Clinical and Experimental Obstetrics & Gynecology nonpronuclear fertilization in vitro fertilization embryo development embryo transfer pregnancy |
| title | Factors Associated with the Occurrence of 0PN Fertilization in in Vitro Fertilization and its Effects on Embryo Development and Reproductive Outcomes |
| title_full | Factors Associated with the Occurrence of 0PN Fertilization in in Vitro Fertilization and its Effects on Embryo Development and Reproductive Outcomes |
| title_fullStr | Factors Associated with the Occurrence of 0PN Fertilization in in Vitro Fertilization and its Effects on Embryo Development and Reproductive Outcomes |
| title_full_unstemmed | Factors Associated with the Occurrence of 0PN Fertilization in in Vitro Fertilization and its Effects on Embryo Development and Reproductive Outcomes |
| title_short | Factors Associated with the Occurrence of 0PN Fertilization in in Vitro Fertilization and its Effects on Embryo Development and Reproductive Outcomes |
| title_sort | factors associated with the occurrence of 0pn fertilization in in vitro fertilization and its effects on embryo development and reproductive outcomes |
| topic | nonpronuclear fertilization in vitro fertilization embryo development embryo transfer pregnancy |
| url | https://www.imrpress.com/journal/CEOG/51/2/10.31083/j.ceog5102032 |
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