Spontaneous, naturally occurring cancers in non-human primates as a translational model for cancer immunotherapy
The complexity of cancer immunotherapy (CIT) demands reliable preclinical models to successfully translate study findings to the clinics. Non-human primates (NHPs; here referring to rhesus and cynomolgus macaques) share broad similarities with humans including physiology, genetic homology, and impor...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-01-01
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| Series: | Journal for ImmunoTherapy of Cancer |
| Online Access: | https://jitc.bmj.com/content/11/1/e005514.full |
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| _version_ | 1832582771823869952 |
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| author | Maurizio Ceppi Bruno Gomes Simon Deycmar Jehad Charo J Mark Cline |
| author_facet | Maurizio Ceppi Bruno Gomes Simon Deycmar Jehad Charo J Mark Cline |
| author_sort | Maurizio Ceppi |
| collection | DOAJ |
| description | The complexity of cancer immunotherapy (CIT) demands reliable preclinical models to successfully translate study findings to the clinics. Non-human primates (NHPs; here referring to rhesus and cynomolgus macaques) share broad similarities with humans including physiology, genetic homology, and importantly also immune cell populations, immune regulatory mechanisms, and protein targets for CIT. Furthermore, NHP naturally develop cancers such as colorectal and breast cancer with an incidence, pathology, and age pattern comparable to humans. Thus, these tumor-bearing monkeys (TBMs) have the potential to bridge the experimental gap between early preclinical cancer models and patients with human cancer.This review presents our current knowledge of NHP immunology, the incidence and features of naturally-occurring cancers in NHP, and recent TBM trials investigating CIT to provide a scientific rationale for this unique model for human cancer. |
| format | Article |
| id | doaj-art-b04b84b73dc0466bafea3714357070fd |
| institution | Kabale University |
| issn | 2051-1426 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Journal for ImmunoTherapy of Cancer |
| spelling | doaj-art-b04b84b73dc0466bafea3714357070fd2025-01-29T09:25:11ZengBMJ Publishing GroupJournal for ImmunoTherapy of Cancer2051-14262023-01-0111110.1136/jitc-2022-005514Spontaneous, naturally occurring cancers in non-human primates as a translational model for cancer immunotherapyMaurizio Ceppi0Bruno Gomes1Simon Deycmar2Jehad Charo3J Mark Cline43Roche Innovation Center Basel, Basel, Switzerland5 Roche Pharmaceutical Research and Early Development Oncology, Roche Innovation Center, Basel, Switzerland1Wake Forest University School of Medicine, Winston Salem, NC, USARoche Innovation Center Zurich, F Hoffmann-La Roche Ltd, Schlieren, SwitzerlandDepartment of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USAThe complexity of cancer immunotherapy (CIT) demands reliable preclinical models to successfully translate study findings to the clinics. Non-human primates (NHPs; here referring to rhesus and cynomolgus macaques) share broad similarities with humans including physiology, genetic homology, and importantly also immune cell populations, immune regulatory mechanisms, and protein targets for CIT. Furthermore, NHP naturally develop cancers such as colorectal and breast cancer with an incidence, pathology, and age pattern comparable to humans. Thus, these tumor-bearing monkeys (TBMs) have the potential to bridge the experimental gap between early preclinical cancer models and patients with human cancer.This review presents our current knowledge of NHP immunology, the incidence and features of naturally-occurring cancers in NHP, and recent TBM trials investigating CIT to provide a scientific rationale for this unique model for human cancer.https://jitc.bmj.com/content/11/1/e005514.full |
| spellingShingle | Maurizio Ceppi Bruno Gomes Simon Deycmar Jehad Charo J Mark Cline Spontaneous, naturally occurring cancers in non-human primates as a translational model for cancer immunotherapy Journal for ImmunoTherapy of Cancer |
| title | Spontaneous, naturally occurring cancers in non-human primates as a translational model for cancer immunotherapy |
| title_full | Spontaneous, naturally occurring cancers in non-human primates as a translational model for cancer immunotherapy |
| title_fullStr | Spontaneous, naturally occurring cancers in non-human primates as a translational model for cancer immunotherapy |
| title_full_unstemmed | Spontaneous, naturally occurring cancers in non-human primates as a translational model for cancer immunotherapy |
| title_short | Spontaneous, naturally occurring cancers in non-human primates as a translational model for cancer immunotherapy |
| title_sort | spontaneous naturally occurring cancers in non human primates as a translational model for cancer immunotherapy |
| url | https://jitc.bmj.com/content/11/1/e005514.full |
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