Effect of Apple (Malus domestica) Stem Cells on UVB-Induced Damage Skin with Anti-Inflammatory Properties: An In Vivo Study
Objective. Apple (Malusdomesticus) stem cells have beneficial effects in preventing photodamages caused by UVB responsible for inflammation in different stages of various skin disorders. This study aimed to investigate Apple stem cells’ anti-inflammatory and repairing effects on UVB-induced rat dors...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2022/2417766 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849692091898134528 |
|---|---|
| author | Danial Khayatan Mohammad Ali Nilforoushzadeh Hamid Reza Ahmadi Ashtiani Farshad Hashemian |
| author_facet | Danial Khayatan Mohammad Ali Nilforoushzadeh Hamid Reza Ahmadi Ashtiani Farshad Hashemian |
| author_sort | Danial Khayatan |
| collection | DOAJ |
| description | Objective. Apple (Malusdomesticus) stem cells have beneficial effects in preventing photodamages caused by UVB responsible for inflammation in different stages of various skin disorders. This study aimed to investigate Apple stem cells’ anti-inflammatory and repairing effects on UVB-induced rat dorsal skin damage via microscopic and macroscopic analyses. Materials and Methods. Therapeutic effects of the apple stem cells (ASCs) extract were evaluated after UVB irradiation with macroscopic and microscopic studies, including pathological analysis, inflammatory cytokines measuring, and biometric studies containing investigation of thickness, density, erythema, melanin, sebum, and moisture content of epidermis and dermis layers in rat models. After biometric studies, skin samples were taken for histopathologic and biochemical analyses. Results. ASC extract could attenuate infiltration of inflammatory cells caused by UVB and ameliorate collagen regulation of the photodamaged skin. In addition, improved skin biometrics was considerable, such as reducing thickened epidermal and dermal layers compared to other rat groups. Furthermore, moisture content enhancement of the skin showed clinical advantages in treating damages and inflammation. Furthermore, TNF-α expression was downregulated after ASC application. ASC extract could treat UVB damages and indicate anti-inflammatory effects in animal models. Conclusion. The ASCs can be an appropriate candidate for treating inflammation and damages induced by UVB in clinical studies. |
| format | Article |
| id | doaj-art-b04a6a79c31e4b9e9a6d06337f85e7c2 |
| institution | DOAJ |
| issn | 1687-8442 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-b04a6a79c31e4b9e9a6d06337f85e7c22025-08-20T03:20:50ZengWileyAdvances in Materials Science and Engineering1687-84422022-01-01202210.1155/2022/2417766Effect of Apple (Malus domestica) Stem Cells on UVB-Induced Damage Skin with Anti-Inflammatory Properties: An In Vivo StudyDanial Khayatan0Mohammad Ali Nilforoushzadeh1Hamid Reza Ahmadi Ashtiani2Farshad Hashemian3Department of Basic SciencesSkin and Stem Cell Research CenterDepartment of Basic SciencesDepartment of Clinical PharmacyObjective. Apple (Malusdomesticus) stem cells have beneficial effects in preventing photodamages caused by UVB responsible for inflammation in different stages of various skin disorders. This study aimed to investigate Apple stem cells’ anti-inflammatory and repairing effects on UVB-induced rat dorsal skin damage via microscopic and macroscopic analyses. Materials and Methods. Therapeutic effects of the apple stem cells (ASCs) extract were evaluated after UVB irradiation with macroscopic and microscopic studies, including pathological analysis, inflammatory cytokines measuring, and biometric studies containing investigation of thickness, density, erythema, melanin, sebum, and moisture content of epidermis and dermis layers in rat models. After biometric studies, skin samples were taken for histopathologic and biochemical analyses. Results. ASC extract could attenuate infiltration of inflammatory cells caused by UVB and ameliorate collagen regulation of the photodamaged skin. In addition, improved skin biometrics was considerable, such as reducing thickened epidermal and dermal layers compared to other rat groups. Furthermore, moisture content enhancement of the skin showed clinical advantages in treating damages and inflammation. Furthermore, TNF-α expression was downregulated after ASC application. ASC extract could treat UVB damages and indicate anti-inflammatory effects in animal models. Conclusion. The ASCs can be an appropriate candidate for treating inflammation and damages induced by UVB in clinical studies.http://dx.doi.org/10.1155/2022/2417766 |
| spellingShingle | Danial Khayatan Mohammad Ali Nilforoushzadeh Hamid Reza Ahmadi Ashtiani Farshad Hashemian Effect of Apple (Malus domestica) Stem Cells on UVB-Induced Damage Skin with Anti-Inflammatory Properties: An In Vivo Study Advances in Materials Science and Engineering |
| title | Effect of Apple (Malus domestica) Stem Cells on UVB-Induced Damage Skin with Anti-Inflammatory Properties: An In Vivo Study |
| title_full | Effect of Apple (Malus domestica) Stem Cells on UVB-Induced Damage Skin with Anti-Inflammatory Properties: An In Vivo Study |
| title_fullStr | Effect of Apple (Malus domestica) Stem Cells on UVB-Induced Damage Skin with Anti-Inflammatory Properties: An In Vivo Study |
| title_full_unstemmed | Effect of Apple (Malus domestica) Stem Cells on UVB-Induced Damage Skin with Anti-Inflammatory Properties: An In Vivo Study |
| title_short | Effect of Apple (Malus domestica) Stem Cells on UVB-Induced Damage Skin with Anti-Inflammatory Properties: An In Vivo Study |
| title_sort | effect of apple malus domestica stem cells on uvb induced damage skin with anti inflammatory properties an in vivo study |
| url | http://dx.doi.org/10.1155/2022/2417766 |
| work_keys_str_mv | AT danialkhayatan effectofapplemalusdomesticastemcellsonuvbinduceddamageskinwithantiinflammatorypropertiesaninvivostudy AT mohammadalinilforoushzadeh effectofapplemalusdomesticastemcellsonuvbinduceddamageskinwithantiinflammatorypropertiesaninvivostudy AT hamidrezaahmadiashtiani effectofapplemalusdomesticastemcellsonuvbinduceddamageskinwithantiinflammatorypropertiesaninvivostudy AT farshadhashemian effectofapplemalusdomesticastemcellsonuvbinduceddamageskinwithantiinflammatorypropertiesaninvivostudy |