Switching antipsychotics: Results of 16-month non-interventional, prospective, observational clinical research of inpatients with schizophrenia spectrum disorders
The study aims to identify prescribing and switching patterns of antipsychotics in clinical practice. A 16-month, prospective study was conducted at the Psychiatric Hospital Idrija, Slovenia. Inpatients (N = 311) with schizophrenia spectrum disorders were observed. The causes for switching antipsych...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2017-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2017-0001 |
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| _version_ | 1832572152801394688 |
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| author | Bole Cvetka Bačar Pišlar Mitja Šen Metka Tavčar Rok Mrhar Aleš |
| author_facet | Bole Cvetka Bačar Pišlar Mitja Šen Metka Tavčar Rok Mrhar Aleš |
| author_sort | Bole Cvetka Bačar |
| collection | DOAJ |
| description | The study aims to identify prescribing and switching patterns of antipsychotics in clinical practice. A 16-month, prospective study was conducted at the Psychiatric Hospital Idrija, Slovenia. Inpatients (N = 311) with schizophrenia spectrum disorders were observed. The causes for switching antipsychotics and switching strategies were analyzed. Analyzing a total of 3954 prescriptions, the collected data confirmed that treatment strategies in this psychiatric hospital are very complex. It was found that 37 percent of inpatients had at least one switch. Moreover, switches that included three or more antipsychotics were detected. The most common causes for switching antipsychotics were adverse reactions and inefficacy or lack of efficacy. Among switching options, abrupt switch was recorded several times. As some patients are receiving several antipsychotics at the same time, it is possible that unusual switching occurs in clinical practice. It seems that the choice of switching strategy is also affected by the cause and urgency for switching an antipsychotic. |
| format | Article |
| id | doaj-art-b03bb0808b2c4fceb989bbe447005ba1 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-b03bb0808b2c4fceb989bbe447005ba12025-02-02T11:49:55ZengSciendoActa Pharmaceutica1846-95582017-03-016719911210.1515/acph-2017-0001acph-2017-0001Switching antipsychotics: Results of 16-month non-interventional, prospective, observational clinical research of inpatients with schizophrenia spectrum disordersBole Cvetka Bačar0Pišlar Mitja1Šen Metka2Tavčar Rok3Mrhar Aleš4Psychiatric Hospital Idrija, SloveniaFaculty of Pharmacy, University of Ljubljana, SloveniaPharmacy Kromberk, Nova Gorica, SloveniaUniversity Psychiatric Hospital Ljubljana, Ljubljana, SloveniaFaculty of Pharmacy, University of Ljubljana, SloveniaThe study aims to identify prescribing and switching patterns of antipsychotics in clinical practice. A 16-month, prospective study was conducted at the Psychiatric Hospital Idrija, Slovenia. Inpatients (N = 311) with schizophrenia spectrum disorders were observed. The causes for switching antipsychotics and switching strategies were analyzed. Analyzing a total of 3954 prescriptions, the collected data confirmed that treatment strategies in this psychiatric hospital are very complex. It was found that 37 percent of inpatients had at least one switch. Moreover, switches that included three or more antipsychotics were detected. The most common causes for switching antipsychotics were adverse reactions and inefficacy or lack of efficacy. Among switching options, abrupt switch was recorded several times. As some patients are receiving several antipsychotics at the same time, it is possible that unusual switching occurs in clinical practice. It seems that the choice of switching strategy is also affected by the cause and urgency for switching an antipsychotic.https://doi.org/10.1515/acph-2017-0001schizophreniaswitching antipsychoticscausesstrategies |
| spellingShingle | Bole Cvetka Bačar Pišlar Mitja Šen Metka Tavčar Rok Mrhar Aleš Switching antipsychotics: Results of 16-month non-interventional, prospective, observational clinical research of inpatients with schizophrenia spectrum disorders Acta Pharmaceutica schizophrenia switching antipsychotics causes strategies |
| title | Switching antipsychotics: Results of 16-month non-interventional, prospective, observational clinical research of inpatients with schizophrenia spectrum disorders |
| title_full | Switching antipsychotics: Results of 16-month non-interventional, prospective, observational clinical research of inpatients with schizophrenia spectrum disorders |
| title_fullStr | Switching antipsychotics: Results of 16-month non-interventional, prospective, observational clinical research of inpatients with schizophrenia spectrum disorders |
| title_full_unstemmed | Switching antipsychotics: Results of 16-month non-interventional, prospective, observational clinical research of inpatients with schizophrenia spectrum disorders |
| title_short | Switching antipsychotics: Results of 16-month non-interventional, prospective, observational clinical research of inpatients with schizophrenia spectrum disorders |
| title_sort | switching antipsychotics results of 16 month non interventional prospective observational clinical research of inpatients with schizophrenia spectrum disorders |
| topic | schizophrenia switching antipsychotics causes strategies |
| url | https://doi.org/10.1515/acph-2017-0001 |
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