IgM has a better relative distribution in inflammation sites and tumor tissues than IgG
Abstract Immunoglobulins (Igs) play a crucial role in host’s defense and in developing therapies against inflammatory diseases and cancer. Herein, we first studied the relative distribution of IgM and IgG in mouse models with acute or chronic inflammation. We found that IgM showed a more selective d...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03213-4 |
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| _version_ | 1849392332804194304 |
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| author | Abdulaziz M. Aldayel Mohammad Bosaeed Sarah Almansour Naif Khalaf Alharbi Mohammed Alenazi Haya A. Aljami Omar Aldibasi Abdulrhman Aljouie Haiyue Xu Zhengrong Cui |
| author_facet | Abdulaziz M. Aldayel Mohammad Bosaeed Sarah Almansour Naif Khalaf Alharbi Mohammed Alenazi Haya A. Aljami Omar Aldibasi Abdulrhman Aljouie Haiyue Xu Zhengrong Cui |
| author_sort | Abdulaziz M. Aldayel |
| collection | DOAJ |
| description | Abstract Immunoglobulins (Igs) play a crucial role in host’s defense and in developing therapies against inflammatory diseases and cancer. Herein, we first studied the relative distribution of IgM and IgG in mouse models with acute or chronic inflammation. We found that IgM showed a more selective distribution towards inflammation sites than IgG. Similarly, in a tumor-bearing mouse model, IgM showed a higher tumor-to-blood or -to healthy organs ratio than IgG. We hypothesized that the difference in the sizes between IgM and IgG may have contributed to the differences in their relative distribution, which was supported by using an IgG nanoparticle system that was similar to IgM in size. To confirm the findings in clinics, we investigated IgM and IgG levels in the blood and bronchoalveolar lavage fluid (BALF) of patients diagnosed with fungal pneumonia and showed that the relative distribution of IgM was significantly higher than IgG in the BALF samples as compared to that in serum. Such an understanding of our immune system at the nano-level may help us develop more effective biotechnological interventions against inflammatory diseases and cancers. Graphical Abstract |
| format | Article |
| id | doaj-art-b03633c1f2d3440e9b784b22bc7628c3 |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-b03633c1f2d3440e9b784b22bc7628c32025-08-20T03:40:47ZengBMCJournal of Nanobiotechnology1477-31552025-03-0123111410.1186/s12951-025-03213-4IgM has a better relative distribution in inflammation sites and tumor tissues than IgGAbdulaziz M. Aldayel0Mohammad Bosaeed1Sarah Almansour2Naif Khalaf Alharbi3Mohammed Alenazi4Haya A. Aljami5Omar Aldibasi6Abdulrhman Aljouie7Haiyue Xu8Zhengrong Cui9College of Pharmacy, Division of Molecular Pharmaceutics and Drug Delivery, The University of Texas at AustinInfectious Diseases Research Department, King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City (KAMC)Infectious Diseases Research Department, King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City (KAMC)Infectious Diseases Research Department, King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City (KAMC)Infectious Diseases Research Department, King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City (KAMC)Infectious Diseases Research Department, King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City (KAMC)Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center (KAIMRC), King Saud Bin Abdulaziz University for Health SciencesDepartment of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center (KAIMRC), King Saud Bin Abdulaziz University for Health SciencesCollege of Pharmacy, Division of Molecular Pharmaceutics and Drug Delivery, The University of Texas at AustinCollege of Pharmacy, Division of Molecular Pharmaceutics and Drug Delivery, The University of Texas at AustinAbstract Immunoglobulins (Igs) play a crucial role in host’s defense and in developing therapies against inflammatory diseases and cancer. Herein, we first studied the relative distribution of IgM and IgG in mouse models with acute or chronic inflammation. We found that IgM showed a more selective distribution towards inflammation sites than IgG. Similarly, in a tumor-bearing mouse model, IgM showed a higher tumor-to-blood or -to healthy organs ratio than IgG. We hypothesized that the difference in the sizes between IgM and IgG may have contributed to the differences in their relative distribution, which was supported by using an IgG nanoparticle system that was similar to IgM in size. To confirm the findings in clinics, we investigated IgM and IgG levels in the blood and bronchoalveolar lavage fluid (BALF) of patients diagnosed with fungal pneumonia and showed that the relative distribution of IgM was significantly higher than IgG in the BALF samples as compared to that in serum. Such an understanding of our immune system at the nano-level may help us develop more effective biotechnological interventions against inflammatory diseases and cancers. Graphical Abstracthttps://doi.org/10.1186/s12951-025-03213-4AntibodiesNanoparticle sizeDistributionInflammationTumor |
| spellingShingle | Abdulaziz M. Aldayel Mohammad Bosaeed Sarah Almansour Naif Khalaf Alharbi Mohammed Alenazi Haya A. Aljami Omar Aldibasi Abdulrhman Aljouie Haiyue Xu Zhengrong Cui IgM has a better relative distribution in inflammation sites and tumor tissues than IgG Journal of Nanobiotechnology Antibodies Nanoparticle size Distribution Inflammation Tumor |
| title | IgM has a better relative distribution in inflammation sites and tumor tissues than IgG |
| title_full | IgM has a better relative distribution in inflammation sites and tumor tissues than IgG |
| title_fullStr | IgM has a better relative distribution in inflammation sites and tumor tissues than IgG |
| title_full_unstemmed | IgM has a better relative distribution in inflammation sites and tumor tissues than IgG |
| title_short | IgM has a better relative distribution in inflammation sites and tumor tissues than IgG |
| title_sort | igm has a better relative distribution in inflammation sites and tumor tissues than igg |
| topic | Antibodies Nanoparticle size Distribution Inflammation Tumor |
| url | https://doi.org/10.1186/s12951-025-03213-4 |
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