Clinical phenotypes of Alzheimer’s disease: investigating atrophy patterns and their pathological correlates

Clinical phenotypes of Alzheimer’s disease: investigating atrophy patterns and their pathological correlates

Abstract Background In Alzheimer’s disease (AD), MRI atrophy patterns can distinguish between amnestic (typical) and non-amnestic (atypical) clinical phenotypes and are increasingly used for diagnosis and outcome measures in clinical trials. However, understanding how protein accumulation and other...

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Bibliographic Details
Main Authors: Niels Reijner, I. Frigerio, M. M. A. Bouwman, B. D. C. Boon, N. Guizard, T. Jubault, J. J. M. Hoozemans, A. J. M. Rozemuller, F. H. Bouwman, F. Barkhof, E. Gordon, W. D. J. van de Berg, L. E. Jonkman
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Cortical volume
Clinical phenotypes
Pathological features
Post-mortem
Online Access:https://doi.org/10.1186/s13195-025-01727-5
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