Calprotectin and Calgranulin C as Biomarkers of Pancreatic Tumors: Baseline Levels and Level Changes after Surgery
Pancreatic tumors and their surgical resection are associated with significant morbidity and mortality, and the biomarkers currently used for these conditions have limited sensitivity and specificity. Because calprotectin and calgranulin C serum levels have been demonstrated to be potential biomarke...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/6985703 |
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| author | Michal Holub Eva Bartáková Alžběta Stráníková Eva Koblihová Simona Arientová Marie Blahutová Jan Máca Miroslav Ryska |
| author_facet | Michal Holub Eva Bartáková Alžběta Stráníková Eva Koblihová Simona Arientová Marie Blahutová Jan Máca Miroslav Ryska |
| author_sort | Michal Holub |
| collection | DOAJ |
| description | Pancreatic tumors and their surgical resection are associated with significant morbidity and mortality, and the biomarkers currently used for these conditions have limited sensitivity and specificity. Because calprotectin and calgranulin C serum levels have been demonstrated to be potential biomarkers of certain cancers and complications of major surgery, the levels of both proteins were tested in the current study in patients with benign and malignant pancreatic tumors that were surgically removed. The baseline serum levels and kinetics of calprotectin and calgranulin C during the 7-day postoperative period were evaluated with immunoassays in 98 adult patients who underwent pancreatic surgery. The baseline serum levels of calprotectin and calgranulin C in patients with malignant (n=84) and benign tumors (n=14) were significantly higher (p<0.01) when compared to those in the healthy controls (n=26). The serum levels of both proteins were also significantly (p<0.05) higher in patients with benign tumors than in those with malignant tumors. After surgery, the serum levels of calprotectin and calgranulin C were significantly (p<0.01) higher than their baseline values, and this elevation persisted throughout the seven days of the follow-up period. Interestingly, starting on day 1 of the postoperative period, the serum levels of both proteins were significantly (p<0.05) higher in the 37 patients who developed postoperative pancreatic fistulas (POPFs) than in the patients who had uneventful recoveries (n=61). Moreover, the serum levels of calprotectin and calgranulin C demonstrated a significant predictive value for the development of POPF; the predictive values of these two proteins were better than those of the serum level of C-reactive protein and the white blood cell count. Taken together, the results of this study suggest that calprotectin and calgranulin C serum levels are potential biomarkers for pancreatic tumors, surgical injury to the pancreatic tissue and the development of POPFs. |
| format | Article |
| id | doaj-art-b02ec652c6d044bab90f24cf79d18826 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b02ec652c6d044bab90f24cf79d188262025-02-03T01:26:21ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/69857036985703Calprotectin and Calgranulin C as Biomarkers of Pancreatic Tumors: Baseline Levels and Level Changes after SurgeryMichal Holub0Eva Bartáková1Alžběta Stráníková2Eva Koblihová3Simona Arientová4Marie Blahutová5Jan Máca6Miroslav Ryska7Department of Infectious Diseases, First Faculty of Medicine, Charles University and Military University Hospital Prague, 169 02 Praha 6, Czech RepublicDepartment of Infectious Diseases, First Faculty of Medicine, Charles University and Military University Hospital Prague, 169 02 Praha 6, Czech RepublicDepartment of Infectious Diseases, First Faculty of Medicine, Charles University and Military University Hospital Prague, 169 02 Praha 6, Czech RepublicDepartment of Surgery, Second Faculty of Medicine, Charles University and Military University Hospital Prague, 169 02 Praha 6, Czech RepublicDepartment of Infectious Diseases, First Faculty of Medicine, Charles University and Military University Hospital Prague, 169 02 Praha 6, Czech RepublicDepartment of Clinical Biochemistry, Military University Hospital Prague, 169 02 Praha 6, Czech RepublicDepartment of Anesthesiology and Intensive Care Medicine, University Hospital of Ostrava, 17. Listopadu 1790/5, 708 52 Ostrava-Poruba, Czech RepublicDepartment of Surgery, Second Faculty of Medicine, Charles University and Military University Hospital Prague, 169 02 Praha 6, Czech RepublicPancreatic tumors and their surgical resection are associated with significant morbidity and mortality, and the biomarkers currently used for these conditions have limited sensitivity and specificity. Because calprotectin and calgranulin C serum levels have been demonstrated to be potential biomarkers of certain cancers and complications of major surgery, the levels of both proteins were tested in the current study in patients with benign and malignant pancreatic tumors that were surgically removed. The baseline serum levels and kinetics of calprotectin and calgranulin C during the 7-day postoperative period were evaluated with immunoassays in 98 adult patients who underwent pancreatic surgery. The baseline serum levels of calprotectin and calgranulin C in patients with malignant (n=84) and benign tumors (n=14) were significantly higher (p<0.01) when compared to those in the healthy controls (n=26). The serum levels of both proteins were also significantly (p<0.05) higher in patients with benign tumors than in those with malignant tumors. After surgery, the serum levels of calprotectin and calgranulin C were significantly (p<0.01) higher than their baseline values, and this elevation persisted throughout the seven days of the follow-up period. Interestingly, starting on day 1 of the postoperative period, the serum levels of both proteins were significantly (p<0.05) higher in the 37 patients who developed postoperative pancreatic fistulas (POPFs) than in the patients who had uneventful recoveries (n=61). Moreover, the serum levels of calprotectin and calgranulin C demonstrated a significant predictive value for the development of POPF; the predictive values of these two proteins were better than those of the serum level of C-reactive protein and the white blood cell count. Taken together, the results of this study suggest that calprotectin and calgranulin C serum levels are potential biomarkers for pancreatic tumors, surgical injury to the pancreatic tissue and the development of POPFs.http://dx.doi.org/10.1155/2019/6985703 |
| spellingShingle | Michal Holub Eva Bartáková Alžběta Stráníková Eva Koblihová Simona Arientová Marie Blahutová Jan Máca Miroslav Ryska Calprotectin and Calgranulin C as Biomarkers of Pancreatic Tumors: Baseline Levels and Level Changes after Surgery Mediators of Inflammation |
| title | Calprotectin and Calgranulin C as Biomarkers of Pancreatic Tumors: Baseline Levels and Level Changes after Surgery |
| title_full | Calprotectin and Calgranulin C as Biomarkers of Pancreatic Tumors: Baseline Levels and Level Changes after Surgery |
| title_fullStr | Calprotectin and Calgranulin C as Biomarkers of Pancreatic Tumors: Baseline Levels and Level Changes after Surgery |
| title_full_unstemmed | Calprotectin and Calgranulin C as Biomarkers of Pancreatic Tumors: Baseline Levels and Level Changes after Surgery |
| title_short | Calprotectin and Calgranulin C as Biomarkers of Pancreatic Tumors: Baseline Levels and Level Changes after Surgery |
| title_sort | calprotectin and calgranulin c as biomarkers of pancreatic tumors baseline levels and level changes after surgery |
| url | http://dx.doi.org/10.1155/2019/6985703 |
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