“Dead Cells Talking”: The Silent Form of Cell Death Is Not so Quiet
After more than twenty years of research, the molecular events of apoptotic cell death can be succinctly stated; different pathways, activated by diverse signals, increase the activity of proteases called caspases that rapidly and irreversibly dismantle condemned cell by cleaving specific substrates...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/453838 |
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| author | Richard Jäger Howard O. Fearnhead |
| author_facet | Richard Jäger Howard O. Fearnhead |
| author_sort | Richard Jäger |
| collection | DOAJ |
| description | After more than twenty years of research, the molecular events of apoptotic cell death can be succinctly stated; different pathways, activated by diverse signals, increase the activity of proteases called caspases that rapidly and irreversibly dismantle condemned cell by cleaving specific substrates. In this time the ideas that apoptosis protects us from tumourigenesis and that cancer chemotherapy works by inducing apoptosis also emerged. Currently, apoptosis research is shifting away from the intracellular events within the dying cell to focus on the effect of apoptotic cells on surrounding tissues. This is producing counterintuitive data showing that our understanding of the role of apoptosis in tumourigenesis and cancer therapy is too simple, with some interesting and provocative implications. Here, we will consider evidence supporting the idea that dying cells signal their presence to the surrounding tissue and, in doing so, elicit repair and regeneration that compensates for any loss of function caused by cell death. We will discuss evidence suggesting that cancer cell proliferation may be driven by inappropriate or corrupted tissue-repair programmes that are initiated by signals from apoptotic cells and show how this may dramatically modify how we view the role of apoptosis in both tumourigenesis and cancer therapy. |
| format | Article |
| id | doaj-art-b02c3e2d4f7144dfb2ac18f2df08b80a |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | Biochemistry Research International |
| spelling | doaj-art-b02c3e2d4f7144dfb2ac18f2df08b80a2025-02-03T05:54:04ZengWileyBiochemistry Research International2090-22472090-22552012-01-01201210.1155/2012/453838453838“Dead Cells Talking”: The Silent Form of Cell Death Is Not so QuietRichard Jäger0Howard O. Fearnhead1Department of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, 53359 Rheinbach, GermanyDepartment of Pharmacology and Therapeutics, NUI Galway, Galway, IrelandAfter more than twenty years of research, the molecular events of apoptotic cell death can be succinctly stated; different pathways, activated by diverse signals, increase the activity of proteases called caspases that rapidly and irreversibly dismantle condemned cell by cleaving specific substrates. In this time the ideas that apoptosis protects us from tumourigenesis and that cancer chemotherapy works by inducing apoptosis also emerged. Currently, apoptosis research is shifting away from the intracellular events within the dying cell to focus on the effect of apoptotic cells on surrounding tissues. This is producing counterintuitive data showing that our understanding of the role of apoptosis in tumourigenesis and cancer therapy is too simple, with some interesting and provocative implications. Here, we will consider evidence supporting the idea that dying cells signal their presence to the surrounding tissue and, in doing so, elicit repair and regeneration that compensates for any loss of function caused by cell death. We will discuss evidence suggesting that cancer cell proliferation may be driven by inappropriate or corrupted tissue-repair programmes that are initiated by signals from apoptotic cells and show how this may dramatically modify how we view the role of apoptosis in both tumourigenesis and cancer therapy.http://dx.doi.org/10.1155/2012/453838 |
| spellingShingle | Richard Jäger Howard O. Fearnhead “Dead Cells Talking”: The Silent Form of Cell Death Is Not so Quiet Biochemistry Research International |
| title | “Dead Cells Talking”: The Silent Form of Cell Death Is Not so Quiet |
| title_full | “Dead Cells Talking”: The Silent Form of Cell Death Is Not so Quiet |
| title_fullStr | “Dead Cells Talking”: The Silent Form of Cell Death Is Not so Quiet |
| title_full_unstemmed | “Dead Cells Talking”: The Silent Form of Cell Death Is Not so Quiet |
| title_short | “Dead Cells Talking”: The Silent Form of Cell Death Is Not so Quiet |
| title_sort | dead cells talking the silent form of cell death is not so quiet |
| url | http://dx.doi.org/10.1155/2012/453838 |
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