The multifaceted impact of physical exercise on FoxO signaling pathways

The multifaceted impact of physical exercise on FoxO signaling pathways

This review explores the multifaceted impact of physical exercise on FoxO signaling pathways, which play a central role in cellular homeostasis, stress response, metabolism, and longevity. Exercise influences FoxO proteins—particularly FoxO1, FoxO3, FoxO4, and FoxO6—through diverse mechanisms, inclu...

Full description

Saved in:

Bibliographic Details
Main Authors:	Wei Liu, Pengjun Meng, Zhi Li, Yifei Shen, Xin Meng, Shen Jin, Mengdi Hu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	FoxO signaling pathways physical exercise metabolic regulation skeletal muscle complex left
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1614732/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39
by: Xing Yu, et al.
Published: (2025-04-01)

Hepatocyte FoxO1 depletion exacerbates hepatic inflammation in MASH by targeting cystathionine γ-lyase
by: Hui-Ting Chen, et al.
Published: (2025-07-01)

Curcumin preserves bone health compromised by diabetes by inhibiting osteoporosis through regulation of the SIRT3/FoxO3a signalling pathway
by: Osama H. Mohammad, et al.
Published: (2025-08-01)

RNAi-Mediated <i>FoxO</i> Silencing Inhibits Reproduction in <i>Locusta migratoria</i>
by: Jiaying Xu, et al.
Published: (2024-11-01)

RHBDF1 promotes PERK expression through the JNK/FoxO3 pathway in breast cancer cells
by: Ryu SungJu, et al.
Published: (2024-10-01)

FoxO3a: capture the bond between magnesium and diabetic kidney disease
by: Taoran Chen, et al.
Published: (2025-08-01)

Fucosterol, a Phytosterol of Marine Algae, Attenuates Immobilization-Induced Skeletal Muscle Atrophy in C57BL/6J Mice
by: Jieun Hwang, et al.
Published: (2024-12-01)

Ablation of macrophage transcriptional factor FoxO1 protects against ischemia–reperfusion injury-induced acute kidney injury
by: Yao He, et al.
Published: (2025-06-01)

Mild hypothermia attenuates hepatic ischemia-reperfusion injury by regulating FoxO1/PPARα pathway
by: Zhongshan Lu, et al.
Published: (2025-08-01)

Upregulation of SIRT1 ameliorates apoptosis of rat nucleus pulposus cells under oxidative stress through FoxO1/β-catenin pathway
by: Hongtao Hu, et al.
Published: (2025-06-01)

Avian Pasteurella multocida induces chicken macrophage apoptosis by inhibiting the Zyxin-FAK-AKT-FoxO1/NF-κB axis
by: Pan Li, et al.
Published: (2024-12-01)

Lactiplantibacillus plantarum FRT4 protects against fatty liver hemorrhage syndrome: regulating gut microbiota and FoxO/TLR-4/NF-κB signaling pathway in laying hens
by: Daojie Li, et al.
Published: (2025-03-01)

Perfluorooctane sulfonate (PFOS) induced bone loss by inhibiting FoxO1-mediated defense against oxidative stress in osteoblast
by: Liming Xue, et al.
Published: (2025-01-01)

Defining the Protein Phosphatase 2A (PP2A) Subcomplexes That Regulate FoxO Transcription Factor Localization
by: Adeline M. Luperchio, et al.
Published: (2025-02-01)

Vanadyl sulfate restores memory impairment in streptozotocin-induced rat model of sporadic alzheimer’s disease by repressing FoxO1 gene expression
by: Akram Ebrahimifar, et al.
Published: (2025-07-01)

Exogenous Nucleotides Supplementation Attenuates Age‐Related Sarcopenia
by: Xin Wu, et al.
Published: (2025-08-01)

Corona or hydrochloric acid modulates embryonic diapause in silkworms by activating different signaling pathways
by: Yuli Zhang, et al.
Published: (2025-02-01)

PD-1 induces autophagy via the PI3K/AKT/FoxO1 pathway to promote infectious bursal disease virus replication
by: Qiuyu Zhang, et al.
Published: (2025-07-01)

Analysis of the Predictive Efficacy and Influencing Factors of Serum Tie-1, FoxO3a, and PKD1 for Lymph Node Metastasis in Cervical Cancer
by: Wang W, et al.
Published: (2025-05-01)

Gypenoside XLIX inhibiting PI3K/AKT/FOXO1 signaling pathway mediated neuronal mitochondrial autophagy to improve patients with ischemic stroke
by: Yonglei Liu, et al.
Published: (2025-08-01)

Daidzein improves muscle atrophy caused by lovastatin by regulating the AMPK/FOXO3a axis
by: Keke Wang, et al.
Published: (2024-12-01)

<i>FoxO1</i> Mediated by H3K27me3 Inhibits Porcine Follicular Development by Regulating the Transcription of <i>CYP1A1</i>
by: Zhi Zhou, et al.
Published: (2024-12-01)

Elucidating the antiviral effects of a novel compound throat anti-viral through metabolomics and network pharmacology: A study on infectious bronchitis virus in poultry
by: Huixin Liu, et al.
Published: (2025-05-01)

Effect of high intensity interval training and detraining on gene expression of AKT/FoxO3a in cardiac and soleus muscle of male rats
by: Shahin Sheibani, et al.
Published: (2020-06-01)

Modulating phosphatase DUSP22 with BML-260 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression
by: Sang-Hoon Lee, et al.
Published: (2025-04-01)

FoxO3a gene down-regulation in pathogenesis of pediatric acute lymphoblastic leukemia
by: Malihe Mirzaie, et al.
Published: (2019-01-01)

The Mechanism of Relieving Diarrheal Irritable Bowel Syndrome Using Polyphenols from <i>Ribes nigrum</i> L. Based on a Network Pharmacology Analysis and 16S rRNA Sequencing
by: Xi Yu, et al.
Published: (2024-11-01)

Effect of urolithin A on intracellular survival of Mycobacterium tuberculosis by regulating AKT-FOXO1-mediated autophagy
by: Jing Bi, et al.
Published: (2025-05-01)

Transcriptome analysis of skeletal muscles revealed the effect of exercise on the molecular mechanisms regulating muscle growth and metabolism in patients with heart failure
by: O. A. Ivanova, et al.
Published: (2020-11-01)

PCYT2 mediates ovarian epithelial cancer metastasis by regulating cell membrane fluidity through the AMPK/FOXO1 signalling pathway
by: Hailin Chen, et al.
Published: (2025-04-01)

Alpha‐Ketoisocaproate Attenuates Muscle Atrophy in Cancer Cachexia Models
by: Pooreum Lim, et al.
Published: (2025-08-01)

A liver-fat crosstalk for iron flux during healthy beiging of adipose tissue
by: Jinying Yang, et al.
Published: (2024-12-01)

Age-related changes in skeletal muscle mitochondria: the role of exercise
by: Dae Yun Seo, et al.
Published: (2016-09-01)

Effects of Sulforaphane Treatment on Skeletal Muscle from Exhaustive Exercise-Induced Inflammation and Oxidative Stress Through the Nrf2/HO-1 Signaling Pathway
by: Ruheea Taskin Ruhee, et al.
Published: (2025-02-01)

Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced Diseases
by: Guangqi Guan, et al.
Published: (2025-01-01)

Advancements of physical exercise and intestinal microbiota and their potential mechanisms
by: Rendong Li, et al.
Published: (2025-07-01)

Fox – Fordyce Disease: a case report
by: Monika Rimdeikaite, et al.
Published: (2025-01-01)

Skeletal Muscle Pathology in Pulmonary Arterial Hypertension and Its Contribution to Exercise Intolerance
by: Thaís C. F. Menezes, et al.
Published: (2025-02-01)

PEAR1 Promotes Myoblast Proliferation Through Notch Signaling Pathway
by: Yahao Zhao, et al.
Published: (2024-12-01)

Exercise and obesity-induced insulin resistance in skeletal muscle
by: Hyo-Bum Kwak
Published: (2013-12-01)