Safety and effect of topical neostigmine ophthalmic solution in animal models

Safety and effect of topical neostigmine ophthalmic solution in animal models

Abstract The study aimed to evaluate the safety and effect of various dosages of topical neostigmine ophthalmic solution (TNOS) in animal models and establish a recommended dosage for further studies on myasthenia gravis (MG) diagnosis. A placebo-controlled, sequential ascending dose study was condu...

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Main Authors: Chuthamas Ongprakobkul, Supharat Jariyakosol, Supanut Apinyawasisuk, Kasem Rattanapinyopituk, Pajaree Chariyavilaskul, Kornvalee Meesilpavikkai, Yuda Chongpison
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Neostigmine
Myasthenia gravis
Eyedrop
Pupil
Animal models
Online Access:https://doi.org/10.1038/s41598-025-16328-3
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https://doi.org/10.1038/s41598-025-16328-3

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