Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy
Diabetic nephropathy (DN) together with glomerular hyperfiltration has been implicated in the development of diabetic microangiopathy in the initial stage of diabetic diseases. Increased amounts of urinary protein in DN may be associated with functional and morphological alterations of podocyte, mai...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/2615286 |
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| _version_ | 1849396689896472576 |
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| author | Haoran Dai Qingquan Liu Baoli Liu |
| author_facet | Haoran Dai Qingquan Liu Baoli Liu |
| author_sort | Haoran Dai |
| collection | DOAJ |
| description | Diabetic nephropathy (DN) together with glomerular hyperfiltration has been implicated in the development of diabetic microangiopathy in the initial stage of diabetic diseases. Increased amounts of urinary protein in DN may be associated with functional and morphological alterations of podocyte, mainly including podocyte hypertrophy, epithelial-mesenchymal transdifferentiation (EMT), podocyte detachment, and podocyte apoptosis. Accumulating studies have revealed that disruption in multiple renal signaling pathways had been critical in the progression of these pathological damages, such as adenosine monophosphate-activated kinase signaling pathways (AMPK), wnt/β-catenin signaling pathways, endoplasmic reticulum stress-related signaling pathways, mammalian target of rapamycin (mTOR)/autophagy pathway, and Rho GTPases. In this review, we highlight new molecular insights underlying podocyte injury in the progression of DN, which offer new therapeutic targets to develop important renoprotective treatments for DN over the next decade. |
| format | Article |
| id | doaj-art-b0200d07b1b84df09efb2f9746331c6c |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-b0200d07b1b84df09efb2f9746331c6c2025-08-20T03:39:15ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/26152862615286Research Progress on Mechanism of Podocyte Depletion in Diabetic NephropathyHaoran Dai0Qingquan Liu1Baoli Liu2Department of Nephrology, Shunyi Branch, Beijing Hospital of Traditional Chinese Medicine, Station East 5, Shunyi District, Beijing 101300, ChinaDepartment of Nephrology, Shunyi Branch, Beijing Hospital of Traditional Chinese Medicine, Station East 5, Shunyi District, Beijing 101300, ChinaDepartment of Nephrology, Shunyi Branch, Beijing Hospital of Traditional Chinese Medicine, Station East 5, Shunyi District, Beijing 101300, ChinaDiabetic nephropathy (DN) together with glomerular hyperfiltration has been implicated in the development of diabetic microangiopathy in the initial stage of diabetic diseases. Increased amounts of urinary protein in DN may be associated with functional and morphological alterations of podocyte, mainly including podocyte hypertrophy, epithelial-mesenchymal transdifferentiation (EMT), podocyte detachment, and podocyte apoptosis. Accumulating studies have revealed that disruption in multiple renal signaling pathways had been critical in the progression of these pathological damages, such as adenosine monophosphate-activated kinase signaling pathways (AMPK), wnt/β-catenin signaling pathways, endoplasmic reticulum stress-related signaling pathways, mammalian target of rapamycin (mTOR)/autophagy pathway, and Rho GTPases. In this review, we highlight new molecular insights underlying podocyte injury in the progression of DN, which offer new therapeutic targets to develop important renoprotective treatments for DN over the next decade.http://dx.doi.org/10.1155/2017/2615286 |
| spellingShingle | Haoran Dai Qingquan Liu Baoli Liu Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy Journal of Diabetes Research |
| title | Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy |
| title_full | Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy |
| title_fullStr | Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy |
| title_full_unstemmed | Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy |
| title_short | Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy |
| title_sort | research progress on mechanism of podocyte depletion in diabetic nephropathy |
| url | http://dx.doi.org/10.1155/2017/2615286 |
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