Latent Inflammation and Insulin Resistance in Adipose Tissue
Obesity is a growing problem in modern society and medicine. It closely associates with metabolic disorders such as type 2 diabetes mellitus (T2DM) and hepatic and cardiovascular diseases such as nonalcoholic fatty liver disease, atherosclerosis, myocarditis, and hypertension. Obesity is often assoc...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/5076732 |
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| author | I. S. Stafeev A. V. Vorotnikov E. I. Ratner M. Y. Menshikov Ye. V. Parfyonova |
| author_facet | I. S. Stafeev A. V. Vorotnikov E. I. Ratner M. Y. Menshikov Ye. V. Parfyonova |
| author_sort | I. S. Stafeev |
| collection | DOAJ |
| description | Obesity is a growing problem in modern society and medicine. It closely associates with metabolic disorders such as type 2 diabetes mellitus (T2DM) and hepatic and cardiovascular diseases such as nonalcoholic fatty liver disease, atherosclerosis, myocarditis, and hypertension. Obesity is often associated with latent inflammation; however, the link between inflammation, obesity, T2DM, and cardiovascular diseases is still poorly understood. Insulin resistance is the earliest feature of metabolic disorders. It mostly develops as a result of dysregulated insulin signaling in insulin-sensitive cells, as compared to inactivating mutations in insulin receptor or signaling proteins that occur relatively rare. Here, we argue that inflammatory signaling provides a link between latent inflammation, obesity, insulin resistance, and metabolic disorders. We further hypothesize that insulin-activated PI3-kinase pathway and inflammatory signaling mediated by several IκB kinases may constitute negative feedback leading to insulin resistance at least in the fat tissue. Finally, we discuss perspectives for anti-inflammatory therapies in treating the metabolic diseases. |
| format | Article |
| id | doaj-art-b01dbd9422c042cf9ad58029c49c616c |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-b01dbd9422c042cf9ad58029c49c616c2025-02-03T01:10:25ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/50767325076732Latent Inflammation and Insulin Resistance in Adipose TissueI. S. Stafeev0A. V. Vorotnikov1E. I. Ratner2M. Y. Menshikov3Ye. V. Parfyonova4Russian Cardiology Research and Production Centre, Moscow 121552, RussiaRussian Cardiology Research and Production Centre, Moscow 121552, RussiaRussian Cardiology Research and Production Centre, Moscow 121552, RussiaRussian Cardiology Research and Production Centre, Moscow 121552, RussiaRussian Cardiology Research and Production Centre, Moscow 121552, RussiaObesity is a growing problem in modern society and medicine. It closely associates with metabolic disorders such as type 2 diabetes mellitus (T2DM) and hepatic and cardiovascular diseases such as nonalcoholic fatty liver disease, atherosclerosis, myocarditis, and hypertension. Obesity is often associated with latent inflammation; however, the link between inflammation, obesity, T2DM, and cardiovascular diseases is still poorly understood. Insulin resistance is the earliest feature of metabolic disorders. It mostly develops as a result of dysregulated insulin signaling in insulin-sensitive cells, as compared to inactivating mutations in insulin receptor or signaling proteins that occur relatively rare. Here, we argue that inflammatory signaling provides a link between latent inflammation, obesity, insulin resistance, and metabolic disorders. We further hypothesize that insulin-activated PI3-kinase pathway and inflammatory signaling mediated by several IκB kinases may constitute negative feedback leading to insulin resistance at least in the fat tissue. Finally, we discuss perspectives for anti-inflammatory therapies in treating the metabolic diseases.http://dx.doi.org/10.1155/2017/5076732 |
| spellingShingle | I. S. Stafeev A. V. Vorotnikov E. I. Ratner M. Y. Menshikov Ye. V. Parfyonova Latent Inflammation and Insulin Resistance in Adipose Tissue International Journal of Endocrinology |
| title | Latent Inflammation and Insulin Resistance in Adipose Tissue |
| title_full | Latent Inflammation and Insulin Resistance in Adipose Tissue |
| title_fullStr | Latent Inflammation and Insulin Resistance in Adipose Tissue |
| title_full_unstemmed | Latent Inflammation and Insulin Resistance in Adipose Tissue |
| title_short | Latent Inflammation and Insulin Resistance in Adipose Tissue |
| title_sort | latent inflammation and insulin resistance in adipose tissue |
| url | http://dx.doi.org/10.1155/2017/5076732 |
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