A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders
Background Cannabis use severely affects the outcome of people with psychotic disorders, yet there is a lack of treatments. To address this, in 2019 the National Health Service (NHS) Cannabis Clinic for Psychosis (CCP) was developed to support adults suffering from psychosis to reduce and/or stop th...
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Cambridge University Press
2025-01-01
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| Series: | BJPsych Open |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472424007828/type/journal_article |
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| author | Marta Di Forti Benjamin W. Bond Edoardo Spinazzola Giulia Trotta Jodie Lynn Richard Malkin Naba Kamran Siddiqui Sultan Demir Titilayomi Opadokun Perry B.M. Leung Zhikun Li Andrea Quattrone Gabriella Baxter Elizabeth Appiah-Kusi Tom P. Freeman Hannah Walsh Tommaso Squeri Daria Semikina Felicity Amberson-Jones Isabelle Austin-Zimmerman Tim Meynen Diego Quattrone Robin M. Murray |
| author_facet | Marta Di Forti Benjamin W. Bond Edoardo Spinazzola Giulia Trotta Jodie Lynn Richard Malkin Naba Kamran Siddiqui Sultan Demir Titilayomi Opadokun Perry B.M. Leung Zhikun Li Andrea Quattrone Gabriella Baxter Elizabeth Appiah-Kusi Tom P. Freeman Hannah Walsh Tommaso Squeri Daria Semikina Felicity Amberson-Jones Isabelle Austin-Zimmerman Tim Meynen Diego Quattrone Robin M. Murray |
| author_sort | Marta Di Forti |
| collection | DOAJ |
| description | Background
Cannabis use severely affects the outcome of people with psychotic disorders, yet there is a lack of treatments. To address this, in 2019 the National Health Service (NHS) Cannabis Clinic for Psychosis (CCP) was developed to support adults suffering from psychosis to reduce and/or stop their cannabis use.
Aims
Examine outcome data from the first 46 individuals to complete the CCP's intervention.
Method
The sample (N = 46) consisted of adults (aged ≥ 18) with psychosis under the care of the South London and Maudsley NHS Foundation Trust, referred to the CCP between January 2020 and February 2023, who completed their intervention by September 2023. Clinical and functional measures were collected before (T0) and after (T1) the CCP intervention (one-to-one sessions and peer group attendance). Primary outcomes were changes in the Cannabis Use Disorders Identification Test-Revised (CUDIT-R) score and pattern of cannabis use. Secondary outcomes included T0–T1 changes in measures of delusions, paranoia, depression, anxiety and functioning.
Results
A reduction in the mean CUDIT-R score was observed between T0 (mean difference = 17.10, 95% CI = 15.54–18.67) and T1, with 73.91% of participants achieving abstinence and 26.09% reducing the frequency and potency of their use. Significant improvements in all clinical and functional outcomes were observed, with 90.70% being in work or education at T1 compared with 8.70% at T0. The variance in CUDIT-R scores explained between 34 and 64% of the variance in our secondary measures.
Conclusions
The CCP intervention is a feasible strategy to support cannabis use cessation/reduction and improve clinical and functional outcomes of people with psychotic disorders.
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| format | Article |
| id | doaj-art-b01d2af12ac54e58ae252d3c48914961 |
| institution | Kabale University |
| issn | 2056-4724 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj-art-b01d2af12ac54e58ae252d3c489149612025-01-27T11:33:07ZengCambridge University PressBJPsych Open2056-47242025-01-011110.1192/bjo.2024.782A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disordersMarta Di Forti0https://orcid.org/0000-0002-3218-6925Benjamin W. Bond1Edoardo Spinazzola2Giulia Trotta3Jodie Lynn4Richard Malkin5Naba Kamran Siddiqui6Sultan Demir7Titilayomi Opadokun8Perry B.M. Leung9https://orcid.org/0000-0002-5292-5641Zhikun Li10Andrea Quattrone11Gabriella Baxter12Elizabeth Appiah-Kusi13Tom P. Freeman14Hannah Walsh15Tommaso Squeri16https://orcid.org/0000-0002-5123-1429Daria Semikina17Felicity Amberson-Jones18Isabelle Austin-Zimmerman19Tim Meynen20Diego Quattrone21Robin M. Murray22Department of Social Genetics and Developmental Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK South London and Maudsley NHS Foundation Mental Health Trust, London, UKSouth London and Maudsley NHS Foundation Mental Health Trust, London, UK Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UKSouth London and Maudsley NHS Foundation Mental Health Trust, London, UK Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UKDepartment of Social Genetics and Developmental Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK South London and Maudsley NHS Foundation Mental Health Trust, London, UKSouth London and Maudsley NHS Foundation Mental Health Trust, London, UKSouth London and Maudsley NHS Foundation Mental Health Trust, London, UK Tees, Esk and Wear Valleys NHS Foundation Trust, Darlington, UKSouth London and Maudsley NHS Foundation Mental Health Trust, London, UKSouth London and Maudsley NHS Foundation Mental Health Trust, London, UKSouth London and Maudsley NHS Foundation Mental Health Trust, London, UKDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SARDepartment of Social Genetics and Developmental Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK Centre for Neurodevelopmental Disorders New Hunt's House, Guy's Campus King's College London, UKSouth London and Maudsley NHS Foundation Mental Health Trust, London, UK Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, PortugalSouth London and Maudsley NHS Foundation Mental Health Trust, London, UKSouth London and Maudsley NHS Foundation Mental Health Trust, London, UKAddiction and Mental Health Group University of Bath, UKDepartment of Addictions, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UKGKT School of Medical Education, King's College London, UKSouth London and Maudsley NHS Foundation Mental Health Trust, London, UKSouth London and Maudsley NHS Foundation Mental Health Trust, London, UKDepartment of Social Genetics and Developmental Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UKDepartment of Social Genetics and Developmental Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK South London and Maudsley NHS Foundation Mental Health Trust, London, UKDepartment of Social Genetics and Developmental Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK South London and Maudsley NHS Foundation Mental Health Trust, London, UKSouth London and Maudsley NHS Foundation Mental Health Trust, London, UK Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UKBackground Cannabis use severely affects the outcome of people with psychotic disorders, yet there is a lack of treatments. To address this, in 2019 the National Health Service (NHS) Cannabis Clinic for Psychosis (CCP) was developed to support adults suffering from psychosis to reduce and/or stop their cannabis use. Aims Examine outcome data from the first 46 individuals to complete the CCP's intervention. Method The sample (N = 46) consisted of adults (aged ≥ 18) with psychosis under the care of the South London and Maudsley NHS Foundation Trust, referred to the CCP between January 2020 and February 2023, who completed their intervention by September 2023. Clinical and functional measures were collected before (T0) and after (T1) the CCP intervention (one-to-one sessions and peer group attendance). Primary outcomes were changes in the Cannabis Use Disorders Identification Test-Revised (CUDIT-R) score and pattern of cannabis use. Secondary outcomes included T0–T1 changes in measures of delusions, paranoia, depression, anxiety and functioning. Results A reduction in the mean CUDIT-R score was observed between T0 (mean difference = 17.10, 95% CI = 15.54–18.67) and T1, with 73.91% of participants achieving abstinence and 26.09% reducing the frequency and potency of their use. Significant improvements in all clinical and functional outcomes were observed, with 90.70% being in work or education at T1 compared with 8.70% at T0. The variance in CUDIT-R scores explained between 34 and 64% of the variance in our secondary measures. Conclusions The CCP intervention is a feasible strategy to support cannabis use cessation/reduction and improve clinical and functional outcomes of people with psychotic disorders. https://www.cambridge.org/core/product/identifier/S2056472424007828/type/journal_articleCannabis usepsychosispsychosocial interventionspersonalisedcessation |
| spellingShingle | Marta Di Forti Benjamin W. Bond Edoardo Spinazzola Giulia Trotta Jodie Lynn Richard Malkin Naba Kamran Siddiqui Sultan Demir Titilayomi Opadokun Perry B.M. Leung Zhikun Li Andrea Quattrone Gabriella Baxter Elizabeth Appiah-Kusi Tom P. Freeman Hannah Walsh Tommaso Squeri Daria Semikina Felicity Amberson-Jones Isabelle Austin-Zimmerman Tim Meynen Diego Quattrone Robin M. Murray A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders BJPsych Open Cannabis use psychosis psychosocial interventions personalised cessation |
| title | A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders |
| title_full | A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders |
| title_fullStr | A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders |
| title_full_unstemmed | A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders |
| title_short | A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders |
| title_sort | proof of concept analysis of data from the first nhs clinic for young adults with comorbid cannabis use and psychotic disorders |
| topic | Cannabis use psychosis psychosocial interventions personalised cessation |
| url | https://www.cambridge.org/core/product/identifier/S2056472424007828/type/journal_article |
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