Immunosuppression and the Immune Response to Transplantation
OBJECTIVES: To review the roles of allorecognition, transplant rejection, and immunosuppressive therapy in predisposing patients to viral infections. DATA SOURCES: Computer and bibliography searches were used to identify relevant articles. STUDY SELECTION AND DATA EXTRACTION: Both review and singl...
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| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1993-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/1993/472736 |
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| _version_ | 1832565525060780032 |
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| author | David Ludwin Dianne Arlen J David Russell |
| author_facet | David Ludwin Dianne Arlen J David Russell |
| author_sort | David Ludwin |
| collection | DOAJ |
| description | OBJECTIVES: To review the roles of allorecognition, transplant rejection, and immunosuppressive therapy
in predisposing patients to viral infections.
DATA SOURCES: Computer and bibliography searches were used to identify relevant articles.
STUDY SELECTION AND DATA EXTRACTION: Both review and single articles were
critically assessed with respect to data analysis and clinical relevance.
CONCLUSIONS: Advances in our knowledge about the nature and regulation of the immune response has enhanced our understanding of
the etiology of transplant rejection. Host factors and immunosuppressive therapy may both be important
in modulating the immune response after transplantation. Viral infections in the post-transplant period
occur not only as a consequence of the immunocompromised state. but viruses themselves may either
augment immunosuppression or initiate rejection. |
| format | Article |
| id | doaj-art-b0197da3fe4746eb93b2175c268b9a98 |
| institution | Kabale University |
| issn | 1180-2332 |
| language | English |
| publishDate | 1993-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases |
| spelling | doaj-art-b0197da3fe4746eb93b2175c268b9a982025-02-03T01:07:27ZengWileyCanadian Journal of Infectious Diseases1180-23321993-01-014Suppl C51010.1155/1993/472736Immunosuppression and the Immune Response to TransplantationDavid LudwinDianne ArlenJ David RussellOBJECTIVES: To review the roles of allorecognition, transplant rejection, and immunosuppressive therapy in predisposing patients to viral infections. DATA SOURCES: Computer and bibliography searches were used to identify relevant articles. STUDY SELECTION AND DATA EXTRACTION: Both review and single articles were critically assessed with respect to data analysis and clinical relevance. CONCLUSIONS: Advances in our knowledge about the nature and regulation of the immune response has enhanced our understanding of the etiology of transplant rejection. Host factors and immunosuppressive therapy may both be important in modulating the immune response after transplantation. Viral infections in the post-transplant period occur not only as a consequence of the immunocompromised state. but viruses themselves may either augment immunosuppression or initiate rejection.http://dx.doi.org/10.1155/1993/472736 |
| spellingShingle | David Ludwin Dianne Arlen J David Russell Immunosuppression and the Immune Response to Transplantation Canadian Journal of Infectious Diseases |
| title | Immunosuppression and the Immune Response to Transplantation |
| title_full | Immunosuppression and the Immune Response to Transplantation |
| title_fullStr | Immunosuppression and the Immune Response to Transplantation |
| title_full_unstemmed | Immunosuppression and the Immune Response to Transplantation |
| title_short | Immunosuppression and the Immune Response to Transplantation |
| title_sort | immunosuppression and the immune response to transplantation |
| url | http://dx.doi.org/10.1155/1993/472736 |
| work_keys_str_mv | AT davidludwin immunosuppressionandtheimmuneresponsetotransplantation AT diannearlen immunosuppressionandtheimmuneresponsetotransplantation AT jdavidrussell immunosuppressionandtheimmuneresponsetotransplantation |