Immunosuppression and the Immune Response to Transplantation
OBJECTIVES: To review the roles of allorecognition, transplant rejection, and immunosuppressive therapy in predisposing patients to viral infections. DATA SOURCES: Computer and bibliography searches were used to identify relevant articles. STUDY SELECTION AND DATA EXTRACTION: Both review and singl...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1993-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/1993/472736 |
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| Summary: | OBJECTIVES: To review the roles of allorecognition, transplant rejection, and immunosuppressive therapy
in predisposing patients to viral infections.
DATA SOURCES: Computer and bibliography searches were used to identify relevant articles.
STUDY SELECTION AND DATA EXTRACTION: Both review and single articles were
critically assessed with respect to data analysis and clinical relevance.
CONCLUSIONS: Advances in our knowledge about the nature and regulation of the immune response has enhanced our understanding of
the etiology of transplant rejection. Host factors and immunosuppressive therapy may both be important
in modulating the immune response after transplantation. Viral infections in the post-transplant period
occur not only as a consequence of the immunocompromised state. but viruses themselves may either
augment immunosuppression or initiate rejection. |
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| ISSN: | 1180-2332 |